Tannic Acid and the Barium Enema

Janower, Murray L.; Robbins, Laurence L.; Tomchik, Frederick S.; Weylman, Walther T.

doi:10.1148/85.5.887

Cited by 25 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Janower et al reported potential hepatotoxicity caused by tannic acid through enema administration in a few cases after barium enema examinations [22] . However, liver toxicity was considered to be secondary to tannic acid administration with the performance of barium enemas.…”

Section: Discussionmentioning

confidence: 99%

Toxicological evaluation of Ultrapure and Potent Tannic Acid (UPPTA) by inhalation exposure

Lu,

Mao,

Tsai

et al. 2023

J. Toxicol. Stud.

View full text Add to dashboard Cite

The therapeutic options for coronal virus infections are limited. As SARS-CoV-2 directly targets the lungs and causes lung damage, treatment of COVID-19 with inhalants may offer more advantages over oral administration. Inhaled drug delivery provides a higher drug concentration in the target organ, where SARS-CoV-2 proliferates. In this study, we evaluated the potential systemic toxicity, relevant target organ toxicity, and toxicokinetics of Airnecflu®, Ultrapure, and Potent Tannic Acid (UPPTA) by metered-dose inhaler (MDI) inhalation to rodent and canine species once a day for 2 consecutive weeks. We further investigated the reversibility of the toxicity following a 3-week recovery period. No mortality related to the test article was observed in all the dose groups. Neither abnormalities related to the test article nor toxicologically significant changes were observed in both rodent and canine studies. In pathological examination, alveolar macrophage aggregation, perivascular/interstitial/alveolar inflammatory cell infiltration, and alveolar/bronchial epithelium hyperplasia were noted in the lung with bronchi involvement. However, after a 3-week recovery period, a substantial recovery was observed. There is limited systemic exposure to the inhalation administration. Therefore, inhalation of Airnecflu® UPPTA is safe to administer for respiratory disorders like COVID-19.

show abstract

Section: Discussionmentioning

confidence: 99%

Toxicological evaluation of Ultrapure and Potent Tannic Acid (UPPTA) by inhalation exposure

Lu,

Mao,

Tsai

et al. 2023

J. Toxicol. Stud.

View full text Add to dashboard Cite

show abstract

“…Overall, our findings indicate that Pentarlandir UPPTA is safe and efficacious. Since Janower et al reported potential hepatotoxicity caused by tannic acids, 27 we have carefully assessed the safety of Pentarlandir UPPTA in vivo under good laboratory practice (GLP) regulations. In the report by Janower et al, tannic acids were added for use as a colonic evacuation enhancer in barium enemas, with a few cases of liver toxicity reported after barium enema examinations.…”

Section: Discussionmentioning

confidence: 99%

“…Such liver failure was presumed to be secondary to tannic acids and/or the performance of barium enemas. 27 We have conducted the 14-day repeat-dose toxicity study under GLP regulations, evaluating a full panel of toxicology endpoints. Our findings showed that the drug candidate had no significant abnormalities in any organs, biochemistry parameters, and other evaluations.…”

Section: Discussionmentioning

confidence: 99%

“…In the report by Janower et al, tannic acids were added for use as a colonic evacuation enhancer in barium enemas, with a few cases of liver toxicity reported after barium enema examinations. Such liver failure was presumed to be secondary to tannic acids and/or the performance of barium enemas . We have conducted the 14-day repeat-dose toxicity study under GLP regulations, evaluating a full panel of toxicology endpoints.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Development of Ultrapure and Potent Tannic Acids as a Pan-coronal Antiviral Therapeutic

Shih¹,

Mao²,

Hu³

et al. 2022

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

The rampageous transmission of SARS-CoV-2 has been devastatingly impacting human life and public health since late 2019. The waves of pandemic events caused by distinct coronaviruses at present and over the past decades have prompted the need to develop broad-spectrum antiviral drugs against them. In this study, our Pentarlandir ultrapure and potent tannic acids (UPPTA) showed activities against two coronaviral strains, SARS-CoV-2 and HCoV-OC43, the earliest-known coronaviruses. The mode of inhibition of Pentarlandir UPPTA is likely to act on 3-chymotrypsin-like protease (3CLpro) to prevent viral replication, as supported by results of biochemical analysis, a 3CLpro assay, and a “gain-of-function” 3CLpro overexpressed cell-based method. Even in the 3CLpro overexpressed environment, Pentarlandir UPPTA remained its antiviral characteristic. Utilizing cell-based virucidal and cytotoxicity assays, the 50% effective concentrations (EC 50 ) and 50% cytotoxicity concentration (CC 50 ) of Pentarlandir UPPTA were determined to be ∼0.5 and 52.5 μM against SARS-CoV-2, while they were 1.3 and 205.9 μM against HCoV-OC43, respectively. In the pharmacokinetic studies, Pentarlandir UPPTA was distributable at a high level to the lung tissue with no accumulation in the body, although the distribution was affected by the food effect. With further investigation in toxicology, Pentarlandir UPPTA demonstrated an overall safe toxicology profile. Taking these findings together, Pentarlandir UPPTA is considered to be a safe and efficacious pancoronal antiviral drug candidate that has been advanced to clinical development.

show abstract

Gastroenterologic Response to Environmental Agents — Absorption and Interactions

Pfeiffer

1977

Comprehensive Physiology

View full text Add to dashboard Cite

The sections in this article are: General Principles of Interaction Between Environmental Agents and the Gut Mucosa Morphological Considerations General and Selected Physicochemical Principles Enteric Absorption and Mucosal Effects of Trace Elements Lead Nickel and Tin Mercury‐Containing Compounds Zinc and Cadmium Copper and Molybdenum Selenium Fluorine and Other Halogens Miscellaneous Trace Elements Mucosal Effects of Chemicals and Corrosives Gastrointestinal Absorption of Pesticides Absorption and Enteric Surface Effects of Miscellaneous Industrial Agents Polychlorinated Biphenyls and Triphenyls Polyglycerol Esters Organic Sulfonates and Other Surface‐Active Agents Dimethylsulfoxide Polyvinylchloride Stabilizers and Plasticizers Absorption and Enteric Surface Effects of Natural Environmental Contaminants Tannic Acid Miscellaneous Natural Compounds Ingestion of Carcinogenic Agents

show abstract

Tannic Acid and the Barium Enema

Cited by 25 publications

References 8 publications

Toxicological evaluation of Ultrapure and Potent Tannic Acid (UPPTA) by inhalation exposure

Toxicological evaluation of Ultrapure and Potent Tannic Acid (UPPTA) by inhalation exposure

Development of Ultrapure and Potent Tannic Acids as a Pan-coronal Antiviral Therapeutic

Gastroenterologic Response to Environmental Agents — Absorption and Interactions

Contact Info

Product

Resources

About