Tannic Acid and Tea Prevents the Accumulation of Lead and Cadmium in the Lungs, Heart and Brain of Adolescent Male Wistar Rats—Possible Therapeutic Option

Abstract

The protective effect of tannic acid and tea solutions on the lungs, hearts and brains of adolescent Wistar rats exposed to Pb and Cd was studied. Metals were administered with feed (7 mg Cd and 50 mg Pb/kg). Two experiments were carried. Experiment 1 aimed to determine the level of tannic acid (TA), most effectively reducing the adverse impact of Pb and Cd on the organs of adolescent rats (aged 5 weeks, weighing 169.3 ± 14.7 g) during combined exposure. TA was administered with drink (0, 0.5, 1, 1.5, 2 or 2.5% solutions). In Experiment 2, adolescent rats (aged 6 weeks, weighing 210.6 ± 12.1 g) received an aqueous solutions of black, green, red or white teas. TA and teas had a positive effect on reducing the accumulation of Cd in the organs. The results obtained suggest that long-term continuing administration of TA increases its effectiveness as a chelator for Pb. A 2% TA and white tea solution proved to be the most effective. In the analyzed tissues, increased activity of SOD and CAT was recorded as a result of the use of the TA and teas; thus, they can efficiently prevent the prooxidant effect of toxic metals.

Cadmium neurotoxicity and therapeutic strategies

“…Mouse Cd (as CdCl 2 ), 10, 25, and 50 mg/L NAC, 150 mg/kg bw Chen et al [37] Rat Cd (as CdCl 2 ), 1.5 mg/kg bw MiADMS, 1 mmol/kg bw Tandon et al [38] Rat Cd (as CdAc 2 ), 50 mg/L α-lipoic acid, 50 mg/kg bw Yuan et al [41] Rat Cd (as CdCl 2 ), 7 mg/kg bw Tannic acid, 1.5%, 2%, and 2.5% aqueous solution Winiarska-Mieczan et al [42] Abbreviations: bw, body weight; Cd, cadmium; CdAc 2 , cadmium acetate; CdCl 2 , cadmium chloride; CNS, central nervous system; MiADMS, monoisoamyl 2,3-dimercaptosuccinate; NAC, N-acetyl-L-cysteine.…”

“…The application of tannic acid causes a significant reduction in the concentration of Cd in rat brains. [ 42 ]…”

“…The application of tannic acid causes a significant reduction in the concentration of Cd in rat brains. [42] In addition, supplementation of elements such as Zn can alleviate the neurotoxicity of Cd. Zn has comparable chemical and physical characteristics to Cd, leading to competition for metal absorptive and enzymatic protein-binding sites.…”