Tandem repeats in precursor protein stabilize transcript levels and production levels of the fungal ribosomally synthesized and post-translationally modified peptide ustiloxin B

Umemura, Maiko; Kuriiwa, Kaoru; Dao, Linh Viet

doi:10.1016/j.fgb.2022.103691

Cited by 3 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We wondered why such highly repetitive sequences are retained ubiquitously in fungi because such structures should be unstable and costly to maintain in the genome. Recently, we reported that the repeat number in a dikaritin precursor protein contributes not only to compound production but also to the transcript level of the precursor protein itself ( Umemura et al., 2022 ). With the increasing number of repeats in the ustiloxin precursor protein, compound production increased quadratically and not linearly.…”

Section: Production Of Ribosomally Synthesized and Post-translational...mentioning

confidence: 99%

How to improve the production of peptidyl compounds in filamentous fungi

Umemura¹,

Tamano²

2022

Front. Fungal Biol.

Self Cite

View full text Add to dashboard Cite

Peptidyl compounds produced by filamentous fungi, which are nonribosomal peptides (NRPs) and ribosomally synthesized and post-translationally modified peptides (RiPPs), are rich sources of bioactive compounds with a wide variety of structures. Some of these peptidyl compounds are useful as pharmaceuticals and pesticides. However, for industrial use, their low production often becomes an obstacle, and various approaches have been challenged to overcome this weakness. In this article, we summarize the successful attempts to increase the production of NRPs and RiPPs in filamentous fungi and present our perspectives on how to improve it further.

show abstract

Section: Production Of Ribosomally Synthesized and Post-translational...mentioning

confidence: 99%

How to improve the production of peptidyl compounds in filamentous fungi

Umemura¹,

Tamano²

2022

Front. Fungal Biol.

Self Cite

View full text Add to dashboard Cite

show abstract

Recent advances in the biosynthesis of ribosomally synthesized and posttranslationally modified peptides of fungal origin

2022

View full text Add to dashboard Cite

Molecular mechanisms of Ustilaginoidea virens pathogenicity and their utilization in disease control

Liu

Wang

et al. 2023

Phytopathol Res

View full text Add to dashboard Cite

Rice false smut, caused by Ustilaginoidea virens, is one of the most important diseases in rice. The disease not only causes significant yield losses in China and worldwide but also produces multiple types of mycotoxins that pose a serious threat to the health of humans and animals. To effectively prevent and control the disease, the pathogenicity mechanisms of U. virens have been studied preliminarily, and some control strategies have been developed. This review focuses on recent progress in understanding the molecular mechanisms of U. virens pathogenicity, including virulence-related genes, transcriptional regulation of virulence genes, and effector-mediated interactions between rice and U. virens. Based on the molecular mechanisms underlying the rice-U. virens interactions, the possibilities of the pathogenicity genes in U. virens and host immune-related genes as potential targets for biological agents, host-induced gene silencing, and molecular design breeding are also discussed.

show abstract

Tandem repeats in precursor protein stabilize transcript levels and production levels of the fungal ribosomally synthesized and post-translationally modified peptide ustiloxin B

Cited by 3 publications

References 34 publications

How to improve the production of peptidyl compounds in filamentous fungi

How to improve the production of peptidyl compounds in filamentous fungi

Recent advances in the biosynthesis of ribosomally synthesized and posttranslationally modified peptides of fungal origin

Molecular mechanisms of Ustilaginoidea virens pathogenicity and their utilization in disease control

Contact Info

Product

Resources

About