Tandem Radical Reactions of Carbon Monoxide, Isonitriles, and Other Reagent Equivalents of the Geminal Radical Acceptor/Radical Precursor Synthon

Synthetic Organic Chemistry Based on Small Ring Compounds

“…[62][63][64] Of these, cyclic cascade carbopalladations [65][66][67][68] have gained wide acceptance and have become a rapidly growing area in synthetic organic chemistry because of their increasing synthetic efficiency. In this context, we developed a novel palladium-mediated successive reaction providing a new general route to benzo-and naphthohydrindans 37 and 38, respectively.…”

A green and convenient approach for the synthesis of 1,10-phenanthrolines via a catalyst- and solvent-free condition

“…Recent challenges in modern organic chemistry encompass the development of methodologies that afford assembly of molecular complexity and diversity in a fewer steps from readily available starting materials, under green conditions and with high yields (1)(2)(3)(4)(5). For this purpose, multicomponent domino reactions (MDRs) play an increasingly important role for the synthesis of chemically and biologically important compounds because of their high degree of atom economy, convergence, productivity, ease of execution, excellent yields, and green chemistry characteristic (6)(7)(8)(9)(10)(11)(12).…”

Iron–Ligand Coordination in Tandem Radical Cyclizations: Synthesis of Benzo[b]thiophenes by a One‐pot Reaction of Iron 1,3‐Diketone Complexes with 2‐Thiosalicylic Acids

“…To the best of our knowledge, iron-mediated tandem radical cyclizations are sparse [5] and the formation of benzo [b]thiophenes through a tandem reaction of coordinated 1,3-diketone ligands has no precedents in the chemistry of metal complexes of 1,3-diketones, a family of coordination compounds that have received numerous attention. [1,6] Our initial finding presented herein came from a hydrothermal reaction of FeA C H T U N G T R E N N U N G (acac) 3 (1A; acac = acetylacetonate) with 2-thiosalicylic acid (2a, 2 equiv) in ethylene glycol (EG) at 120 8C for 12 h; this unexpectedly afforded Fe II complex 3, which contains coordinated benzo [b]thiophene derivatives (Scheme 1).…”

“…Complex 13 shows an emission maximum at 564 nm with a quantum yield of 0.28 (at 1.0 10 À5 m) at 298 K; this is tentatively assigned to be originated from a mixed We have demonstrated an interesting type of tandem radical cyclization reaction, which involves an iron-mediated redox transformation and occurs at the coordinated ligands with product yields of up to 98 %. Tandem radical cyclizations are an important class of reactions of great utility in organic synthesis [5] and the use of redox-active Fe III reagents is promising in this endeavor. Pt II complexes with ppy and deprotonated 5Aa or 5Ha ligands have been prepared to reveal the potential use of the benzo [b]thiophene ligand system in the design of new Pt-based phosphorescent materials.…”