Tandem Cyclization Reaction of Diphenyl 3,5-Di-tert-butyl-p-quinone Phosphonate Catalyzed by Trifluoromethanesulfonic Acid: Introduce a Comprehensive Experiment of Organic Chemistry

Abstract

Synthesis and structural characterization of organic compounds are important content of organic chemistry laboratory teaching. This article introduces a comprehensive organic chemistry experiment which carried out at College of Chemistry, Nankai University. In this experiment, diphenyl 3,5-di-tert-butyl-p-quinone phosphonate and 2methylbenzene-1,3-diol are the reactants, and the tandem cyclization reaction occurred under the catalysis of trifluoromethanesulfonic acid to generate benzo [d] [1,2] oxaphosphole 2-oxide. The structure of the product is characterized by 1 H NMR, 13 C, 13 P NMR and HRMS.