Abstract:For several decades, in breast cancer patients with a luminal subtype, tamoxifen has been the main endocrine therapy in adjuvant setting in both pre-and postmenopausal women. However, it may be suboptimal in some premenopausal patients. The results of prospective, randomised studies SOFT/TEXT clearly demonstrated that the combination of OFS with TAM or IA is more effective than monotherapy TAM in breast cancer premenopausal women with hormonesensitive early breast cancer and a high risk of recurrence. NOWOTWOR… Show more
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