Tamoxifen monitoring studies in breast cancer patients by micellar liquid chromatography

Esteve‐Romero, Josep; Ochoa-Aranda, Enrique; Bose, Devasish; Rambla-Alegre, Maria; Péris-Vicente, Juan; Martinavarro-Domı́nguez, Adria

doi:10.1007/s00216-010-3695-7

Cited by 40 publications

(30 citation statements)

References 23 publications

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“…The experimental procedure was taken from a previously published paper devoted to the analysis of TAMO in a plasma sample, 29,30 and adapted to a different matrix: the tablet. The irradiation conditions were kept.…”

Section: Optimization Of the Sample Treatmentmentioning

confidence: 99%

“…As TAMO is not fluorogen, it must be previously activated by photo-cyclization induced by irradiation to form a derivative with a phenanthrene core, which shows intense fluorescence. [28][29][30] We have previously developed a micellar liquid chromatographic (MLC) method, coupled with FLD for the quantification of tamoxifen in plasma with excellent results. 29,30 Anionic sodium dodecyl sulfate (SDS) was used as a surfactant, due to its low cost, critic micellar concentration, Krafft point and viscosity, as well as high solubility in water and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

“…[28][29][30] We have previously developed a micellar liquid chromatographic (MLC) method, coupled with FLD for the quantification of tamoxifen in plasma with excellent results. 29,30 Anionic sodium dodecyl sulfate (SDS) was used as a surfactant, due to its low cost, critic micellar concentration, Krafft point and viscosity, as well as high solubility in water and biodegradability. 31 This method can be adapted to analyze solids.…”

Section: Introductionmentioning

confidence: 99%

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Quantification of Tamoxifen in Pharmaceutical Formulations Using Micellar Liquid Chromatography

2014

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This paper describes a micellar liquid chromatographic method used to analyze tamoxifen (TAMO) in pharmaceutical formulations, while focusing in its interesting features. Solid samples were solved in a micellar solution, irradiated at 254 nm, filtered and injected. Extraction steps were avoided and thus expediting the procedure. Tamoxifen was resolved in <5 min, using a mobile phase containing 0.15 M sodium dodecyl sulfate-7% pentanol at pH 3, running at 1.5 mL/min under an isocratic mode at 40 C through a C18 column. Detection was achieved by fluorescence by excitation at 260 nm and emission at 380 nm. The validation was performed following the requirements of the International Conference on Harmonization (ICH) Tripartite Guidelines in terms of: specificity, sensitivity, calibration range (0.2 -20 mg/L), accuracy (98.8 -101.7%), precision (<1.5%) and robustness (<6.2%). The method was applied to quantify TAMO in TAMO citrate tablets supplied in Spain, and was found appropriate for the quality control of TAMO formulations.

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Section: Optimization Of the Sample Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantification of Tamoxifen in Pharmaceutical Formulations Using Micellar Liquid Chromatography

2014

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“…Finally, further evaluation of TDM approaches is needed to determine whether the assessment of tamoxifen in plasma could be useful as a complementary tool for guiding drug dosage in breast cancer patients [103].…”

Section: Tamoxifenmentioning

confidence: 99%

Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy

Gervasini

Benı́tez

Carrillo

2010

Eur J Clin Pharmacol

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“…Micellar mobile phases usually need less quantity of organic modifier and generate less amount of toxic waste in comparison to aqueous-organic solvents, so that they are less toxic, non-flammable, biodegradable and relatively inexpensive [21]. MLC has proved to be a useful technique in the determination of diverse groups of compounds in several matrices [23][24][25][26][27], including food samples [8,9,28,29].…”

Section: Introductionmentioning

confidence: 99%

Determination of Putrescine and Tyramine in Fish by Micellar Liquid Chromatography with UV Detection Using Direct Injection

Chin-Chen¹

2011

TOACJ

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This paper shows how fish samples could be directly injected into a chromatograph, without any previous extraction, using micellar liquid chromatography, taking as an example the determination of two biogenic amines: putrescine and tyramine, derivatized with 3,5-dinitrobenzoyl chloride. First, the method has been optimized, using an interpretive model, and the best conditions for analysis were: mobile phase containing 0.15 M SDS-6% (v/v) butanol-pH 7, C18 column (125 0.46 mm, 5 μm particle size), UV detection of derivatives set at 260 nm. Second, the method has been validated using spiked samples following the guidelines proposed by the US Food and Drug Administration: linear in the range from 0.5 to 1000 ppm (r 2 >0.999), detection limits of 30 and 40 ppb for putrescine and tyramine, respectively, a 500 ppb limit of quantification in both cases, intra-and inter-day precision (RSD) below 2%, and accuracy between 99.5% and 102.7%. The method is adequate for routine analysis in the determination of these compounds in fish sauces.

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Tamoxifen monitoring studies in breast cancer patients by micellar liquid chromatography

Cited by 40 publications

References 23 publications

Quantification of Tamoxifen in Pharmaceutical Formulations Using Micellar Liquid Chromatography

Quantification of Tamoxifen in Pharmaceutical Formulations Using Micellar Liquid Chromatography

Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy

Determination of Putrescine and Tyramine in Fish by Micellar Liquid Chromatography with UV Detection Using Direct Injection

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