Tamoxifen modulates mitochondrial dynamics through AMPK and MAPK during nutrition deprivation

Vijayakumar, Gangipangi; Swetha, Uppalapati S; Selvaraju, Sudhagar

doi:10.1002/cbin.11853

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…In tamoxifen-resistant breast cancer cells, overall mitochondrial dysfunctions were observed accompanying AMPK phosphorylation at Ser485/491, but not at Thr172 [ 196 ]. However, studies have also shown that tamoxifen regulated AMPK by increasing AMP/ATP ratios and consequently enhancing mitochondrial fusion [ 11 , 197 ]. Interestingly, tamoxifen bidirectionally regulates autophagic processes under various conditions.…”

Section: Potential Ampk Modulators Of Chemical Synthesismentioning

confidence: 99%

Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer

et al. 2023

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Breast cancer is a common cancer in women worldwide. The existing clinical treatment strategies have been able to limit the progression of breast cancer and cancer metastasis, but abnormal metabolism, immunosuppression, and multidrug resistance involving multiple regulators remain the major challenges for the treatment of breast cancer. Adenosine 5′-monophosphate (AMP)-Activated Protein Kinase (AMPK) can regulate metabolic reprogramming and reverse the “Warburg effect” via multiple metabolic signaling pathways in breast cancer. Previous studies suggest that the activation of AMPK suppresses the growth and metastasis of breast cancer cells, as well as stimulating the responses of immune cells. However, some other reports claim that the development and poor prognosis of breast cancer are related to the overexpression and aberrant activation of AMPK. Thus, the role of AMPK in the progression of breast cancer is still controversial. In this review, we summarize the current understanding of AMPK, particularly the comprehensive bidirectional functions of AMPK in cancer progression; discuss the pharmacological activators of AMPK and some specific molecules, including the natural products (including berberine, curcumin, (−)-epigallocatechin-3-gallate, ginsenosides, and paclitaxel) that influence the efficacy of these activators in cancer therapy; and elaborate the role of AMPK as a potential therapeutic target for the treatment of breast cancer.

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Section: Potential Ampk Modulators Of Chemical Synthesismentioning

confidence: 99%

Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer

et al. 2023

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“…Recently, it was demonstrated that mitochondrial fusion dramatically decreases the susceptibility of breast cancer cells to tamoxifen under metabolic stress and likely contributes to the development of acquired drug resistance through AMPK and MAPK signalling [268]. Through p44/42 MAPK-Drp1 (a dynamin-related GTPase) signalling, membrane-bounded G-protein coupled oestrogen receptor (GPER) causes mitochondria fission, which is essential for GPER-induced cell apoptosis in breast cancer cells [269].…”

Section: Mapk Pathwaymentioning

confidence: 99%

Dysregulated Signalling Pathways Driving Anticancer Drug Resistance

Bou Antoun,

Chioni

2023

IJMS

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One of the leading causes of death worldwide, in both men and women, is cancer. Despite the significant development in therapeutic strategies, the inevitable emergence of drug resistance limits the success and impedes the curative outcome. Intrinsic and acquired resistance are common mechanisms responsible for cancer relapse. Several factors crucially regulate tumourigenesis and resistance, including physical barriers, tumour microenvironment (TME), heterogeneity, genetic and epigenetic alterations, the immune system, tumour burden, growth kinetics and undruggable targets. Moreover, transforming growth factor-beta (TGF-β), Notch, epidermal growth factor receptor (EGFR), integrin-extracellular matrix (ECM), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), phosphoinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR), wingless-related integration site (Wnt/β-catenin), Janus kinase/signal transducers and activators of transcription (JAK/STAT) and RAS/RAF/mitogen-activated protein kinase (MAPK) signalling pathways are some of the key players that have a pivotal role in drug resistance mechanisms. To guide future cancer treatments and improve results, a deeper comprehension of drug resistance pathways is necessary. This review covers both intrinsic and acquired resistance and gives a comprehensive overview of recent research on mechanisms that enable cancer cells to bypass barriers put up by treatments, and, like “satellite navigation”, find alternative routes by which to carry on their “journey” to cancer progression.

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Tamoxifen modulates nutrition deprivation-induced ER stress through AMPK-mediated ER-phagy in breast cancer cells

Bidisha,

Sowmya,

Shalini

et al. 2024

Breast Cancer Res Treat

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Tamoxifen modulates mitochondrial dynamics through AMPK and MAPK during nutrition deprivation

Cited by 5 publications

References 33 publications

Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer

Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer

Dysregulated Signalling Pathways Driving Anticancer Drug Resistance

Tamoxifen modulates nutrition deprivation-induced ER stress through AMPK-mediated ER-phagy in breast cancer cells

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