Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases

Elkin, Adam D.; Jacobs, Charlotte

doi:10.1007/s00432-008-0377-3

Cited by 38 publications

(30 citation statements)

References 12 publications

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“…It has been suggested that there may be a hormonal influence accounting for the different biological behaviors of ACC among the sexes. 22 Reports of αER and PR expression in salivary gland ACC range from 0% to 100%. 23-25 Possible explanations for this variation include clone variability and different methods of antigen retrieval.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic predictors of recurrence and overall survival in adenoid cystic carcinoma of the head and neck: A single institutional experience at a tertiary care center

et al. 2014

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Background The purpose of this study was to determine factors that impact recurrence and long-term survival of head and neck adenoid cystic carcinoma (ACC). Methods We conducted a retrospective review of 87 patients with head and neck ACC who were evaluated between 1992 and 2009. Staining for Ki-67, p53, α-estrogen receptor (αER), and progesterone receptor (PR) was performed. Results Forty men (46%) and 47 women (54%) were included in this study. Median follow-up for patients was 98 months. Five-year recurrence-free and overall survival (OS) rates were 56% and 81%, respectively. Ki-67 and p53 expression was observed in 5 (6%) and 2 (2%) patients, respectively. αER and PR were all negative. The most important determinants of disease-free survival (DFS) were perineural invasion (PNI; p = .001) and female sex (p = .027). Disease site (major vs minor salivary gland) was the only predictor of worse OS on multivariate analysis. Conclusion Perineural invasion, female sex, and disease site were the most consistent predictors of poor outcome in head and neck ACC.

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic predictors of recurrence and overall survival in adenoid cystic carcinoma of the head and neck: A single institutional experience at a tertiary care center

et al. 2014

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“…In contrast, it has been reported that some SGC possess hormonal receptors, such as estrogen [88] or progesterone [89-92] or even androgen receptors in salivary duct carcinoma [92]. In light of these reports, hormonal treatment has been used occasionally, and isolated case reports document objective responses in patients with ACC treated with tamoxifen [93,94] and in patients with salivary duct cancer and adenocarcinoma treated with antiandrogen therapy [95,96]. To date, no phase II studies have been performed, so it is difficult to define the role of hormone therapy in SGC.…”

Section: Methodsmentioning

confidence: 99%

Systemic therapy in the management of metastatic or advanced salivary gland cancers

et al. 2012

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Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers.

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“…There are few reports on antihormone therapies in salivary gland carcinomas, although Elkin and Jacobs. 26 reported long-term therapeutic effect in two ACC patients treated with tamoxifen/toremifene. Thus, ER is another possibility for specific targeting in the treatment of patients with ACC.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Analysis of Various Salivary Gland Carcinomas Focusing on the Possibility of Molecular-targeted and Hormonal Therapy

Kawamura

Kunimura

Omatsu

et al. 2013

Showa Univ J Med Sci

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: This study aimed to determine the expression of c-kit, human epidermal growth factor receptor type 2 HER2 , insulin-like growth factor receptor IGFR , estrogen receptor ER , progesterone receptor PgR , vascular endothelial growth factor VEGF , c-MET, and survivin in adenoid cystic carcinomas ACC , carcinomas ex pleomorphic adenomas CXPA , and mucoepidermoid carcinomas MEC of the salivary glands. These expression levels and locations were compared to estimate the availability of molecular and hormonal targets for therapy in salivary gland carcinomas. Forty patients with a salivary gland carcinoma, diagnosed and treated at our hospital, were studied. On the basis of histopathology, 13, 12, and 15 patients were diagnosed with ACC, CXPA, and MEC, respectively. Associations between histological types were evaluated by Fisher s exact test, with a significance level of P 0.05. Compared with the other two histological types, ACC samples demonstrated significantly higher c-kit 85 , IGFR 77 , and ER 38 expression, while CXPA demonstrated significant HER2 75 staining, and MEC demonstrated significant IGFR 77 staining. The differences in expression of the tested markers among the histological types in our study suggested that c-kit-and IGFR-targeted therapy and anti-estrogen treatment could be effective in ACC, HER2-targeted therapy could be effective in CXPA, and that IGFR-target therapy could be effective in MEC of the salivary glands.

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Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases

Abstract: Given the relatively unsuccessful treatments for ACC-SC and the low toxicity of ER antagonists, such therapy should be considered in these patients for its potential disease-stabilizing effects.

Cited by 38 publications

References 12 publications

Clinicopathologic predictors of recurrence and overall survival in adenoid cystic carcinoma of the head and neck: A single institutional experience at a tertiary care center

Clinicopathologic predictors of recurrence and overall survival in adenoid cystic carcinoma of the head and neck: A single institutional experience at a tertiary care center

Systemic therapy in the management of metastatic or advanced salivary gland cancers

Immunohistochemical Analysis of Various Salivary Gland Carcinomas Focusing on the Possibility of Molecular-targeted and Hormonal Therapy

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