Tamoxifen citrate loaded biodegradable poly(sebacic acid-co- ricinoleic acid) microparticles, in vitro characterization

Paclitaxel loaded poly (DL lactic acid co castor oil) 60:40 with poloxamer‐F68 rod shape cylindrical nanoparticle preparation and in vitro cytotoxicity studies

“…Our previous work supports this circumstance of drug release: We formed tamoxifen citrate as microparticles, and only 90% of the drug was released after 90 hours. During 35 days of dissolution in implants, only 70% of tamoxifen citrate was released using poly (sebacic acid‐co‐ricinoleic acid, 70:30) . Our investigations propose that PTX is released from the nanoparticle as a function of water penetration into the polymer lattice and drug release from the polymer.…”

“…During 35 days of dissolution in implants, only 70% of tamoxifen citrate was released using poly (sebacic acid-co-ricinoleic acid, 70:30). 24,[37][38][39] Our investigations propose that PTX is released from the nanoparticle as a function of water penetration into the polymer lattice and drug release from the polymer. The increase in polymer lattice hydrophobicity reduces the water penetration leading to an increase in interactions between the polymer and the drug was concluded.…”

Paclitaxel loaded biodegradable poly (sebacic acid-co-ricinoleic acid) cylindrical implants for local delivery-in vitro characterization

“…There was no significant change in drug content in all the formulations. [12] In case of formulations F1 and F2 only the characteristics bands of polymer was obtained at 2934.2, 1699.7, 1299.4 cm −1 , respectively. FTIR studies revealed that, physical mixture shows absorption bands for both drug and polymer, indicated that there was no chemical or physical interaction between drug and polymer during preparation of implants.…”

“…The melting endothermic peak of pure PTX appeared at 220.0°C. Sharp and broadened endothermic peaks of poly (SA-RA) [12] and physical mixture were observed at 119.41 and 120.27/226.42°C, respectively. In case of formulations F1 and F2, broadened endothermic peaks were generated at 121.52 and 122.74°C.…”

“…[13] X-ray diffraction The diffraction peaks of PTX were observed at 10.82, 12.90, 14.96, 17.97, 25.08, 43.744° (2θ) [ Figure 4a]. In case of pure polymer, diffraction peaks were observed at 5.27, 20.22, 21.73, 25.3° (2θ) [12] [ Figure 4b]. Physical mixture of drug and polymer when subjected for XRD, same prominent diffraction peaks of drug and polymer were observed in the mixture at 7.61, 17.76, 19.58, 21.91° (2θ) [ Figure 4c].…”