Tamoxifen and Endometrial Cancer

Barakat, Richard R.

doi:10.1177/107327489600300202

Cited by 2 publications

(3 citation statements)

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“…Available data indicate, however, that tamoxifen can to some extent mimic E 2 action as well, and it has been reported to have some moderate estrogenic effects (Barakat 1996).…”

Section: Figmentioning

confidence: 98%

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Synergistic cytotoxic effects of tamoxifen and black cohosh on MCF-7 and MDA-MB-231 human breast cancer cells: an in vitro studyThis article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products.

Al-Akoum

Dodin

Akoum

2007

Can. J. Physiol. Pharmacol.

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Breast cancer cell cultures were exposed to different concentrations of black cohosh, estradiol (E2), and tamoxifen to examine the effect on cell proliferation; cytotoxicity was assessed by using sulforhodamine B (SRB) dye solution. E2 (10(-10) - 10(-8) mol/L) markedly stimulated the proliferation of MCF-7 cells (p < 0.01). Tamoxifen stimulated MCF-7 cell proliferation at 10(-6) mol/L and 10(-5) mol/L (p < 0.005) but inhibited in a dose-dependent fashion the proliferative effect of E2 (p < 0.001). Black cohosh alone did not show any stimulatory effect, but exhibited a cytotoxic effect, which was significant at 10(3) microg/mL (p < 0.001). Adding black cohosh at 10(0)-10(3) microg/mL to E2 at 10(-9) mol/L also resulted in a dose-dependent inhibition of E2 proliferative effect. Interestingly, the combination of black cohosh (10(0)-10(3) microg/mL) with increasing tamoxifen concentrations further inhibited MCF-7 cell growth. On MDA-MB-231 cells, neither E2 nor tamoxifen displayed any detectable effect. However, black cohosh inhibited MDA-MB-231 cell proliferation at 10(3) microg/mL (p < 0.05), and this inhibitory effect was enhanced by increasing tamoxifen concentrations. This study reveals a cytotoxic effect of black cohosh on both estrogen-sensitive and estrogen-insensitive breast cancer cells and a synergism with tamoxifen for inhibition of cancerous cell growth.

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“…Available data indicate, however, that tamoxifen can to some extent mimic E 2 action as well, and it has been reported to have some moderate estrogenic effects (Barakat 1996).…”

Section: Figmentioning

confidence: 98%

“…Tamoxifen, a selective estrogen receptor modulator (SERM), is commonly used in the management of patients with estrogen-dependent breast cancer (Barakat 1996).…”

Section: Introductionmentioning

confidence: 99%

Synergistic cytotoxic effects of tamoxifen and black cohosh on MCF-7 and MDA-MB-231 human breast cancer cells: an in vitro studyThis article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products.

Al-Akoum

Dodin

Akoum

2007

Can. J. Physiol. Pharmacol.

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show abstract

“…In humans, there is now an accepted association between tamoxifen use and an increased risk of endometrial cancer, but as yet no definite association with an increased risk of any other malignancies (Jordan 1995b, Barakat 1996. Endometrial carcinoma In the mid 1980s, a number of authors reported the occurrence of endometrial cancers in patients with breast cancer receiving tamoxifen (Killackey et al 1985).…”

Section: Risk Of Second Malignancies With Tamoxifen Usementioning

confidence: 99%