Taming of Covid-19: potential and emerging application of mesenchymal stem cells

Abstract

Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has turned out to cause a pandemic, with a sky scraping mortality. The virus is thought to cause tissue injury by affecting the reninangiotensin system. Also, the role of the overactivated immune system is noteworthy, leading to severe tissue injury via the cytokine storms. Thus it would be feasible to modulate the immune system response in order to attenuate the disease severity, as well as treating the patients. Today different medicines are being administered to the patients, but regardless of the efficacy of these treatments, adverse effects are pretty probable. Meanwhile, mesenchymal stem cells (MSCs) prove to be an effective candidate for treating the patients suffering from COVID-19 pneumonia, owing to their immunomodulatory and tissue-regenerative potentials. So far, several experiments have been conducted; transplanting MSCs and results are satisfying with no adverse effects being reported. This paper aims to review the recent findings regarding the novel coronavirus and the conducted experiments to treat patients suffering from COVID-19 pneumonia utilizing MSCs.

A case series on safety and tolerability of human umbilical cord-derived mesenchymal stem cells on patients in Malaysia

“…MSCs have been explored as a potential treatment for a wide range of acute and chronic illnesses. 4 In Malaysia, regenerative medicine therapy is rapidly and constantly developing, with various ongoing clinical trials in a wide range of fields, including oncology, orthopaedics and anti-ageing. 5 Liver dysfunction is a chronic condition of increasing concern worldwide, with numerous causes ranging from viral hepatitis to alcohol abuse and non-alcoholic fatty liver disease.…”

Predict the hospitalization in COVID-19: Magic is in the air

“…The most common symptoms observed in the patients are fever, cough, breathing di culties, loss of smell and taste, dizziness, muscle pain, fatigue, abdominal pain, and loose motion. The severity of disease proportionately increases with age and the presence of comorbidities (1,2).…”