TAM and TIM receptors mRNA expression in Zika virus infected placentas

Nobrega, Guilherme de Moraes; Samogim, Ana Paula; Parise, Pierina Lorencini; Venceslau, Emanuella Meneses; Guida, José Paulo; Japecanga, Rodolfo Rosa; Amorim, Mariene R.; Toledo-Teixeira, Daniel A.; Forato, Julia; Consonni, Sílvio Roberto; Costa, Maria Laura; Proença-Módena, José Luiz

doi:10.1016/j.placenta.2020.09.062

Cited by 10 publications

(10 citation statements)

References 25 publications

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“…71,143 ZIKV infects HBCs and chorionic trophoblasts (CTB) using entry cofactors Axl, Tyro3, and TIMI. 144,145 In vitro ZIKV infection of HBC is augmented by IgG from prior flavivirus exposure through antibody-dependent enhancement (ADE). 146 Infection is intensified through the hyperplasia and proliferation of HBCs, thereby amplifying potential targets.…”

Section: Viral and Bacterial Infectionsmentioning

confidence: 99%

“…ZIKV is also able to replicate within macrophages by targeting FcR, TLR4, DC‐SIGN receptors 71,143 . ZIKV infects HBCs and chorionic trophoblasts (CTB) using entry cofactors Axl, Tyro3, and TIMI 144,145 . In vitro ZIKV infection of HBC is augmented by IgG from prior flavivirus exposure through antibody‐dependent enhancement (ADE) 146 .…”

Section: Role Of Monocytes and Macrophages In Pregnancy Complicationsmentioning

confidence: 99%

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Monocytes and macrophages in pregnancy: The good, the bad, and the ugly*

True

Blanton

Sureshchandra

et al. 2022

Immunological Reviews

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A successful human pregnancy requires precisely timed adaptations by the maternal immune system to support fetal growth while simultaneously protecting mother and fetus against microbial challenges. The first trimester of pregnancy is characterized by a robust increase in innate immune activity that promotes successful implantation of the blastocyst and placental development. Moreover, early pregnancy is also a state of increased vulnerability to vertically transmitted pathogens notably, human immunodeficiency virus (HIV), Zika virus (ZIKV), SARS‐CoV‐2, and Listeria monocytogenes. As gestation progresses, the second trimester is marked by the establishment of an immunosuppressive environment that promotes fetal tolerance and growth while preventing preterm birth, spontaneous abortion, and other gestational complications. Finally, the period leading up to labor and parturition is characterized by the reinstatement of an inflammatory milieu triggering childbirth. These dynamic waves of carefully orchestrated changes have been dubbed the “immune clock of pregnancy.” Monocytes in maternal circulation and tissue‐resident macrophages at the maternal‐fetal interface play a critical role in this delicate balance. This review will summarize the current data describing the longitudinal changes in the phenotype and function of monocyte and macrophage populations in healthy and complicated pregnancies.

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Section: Viral and Bacterial Infectionsmentioning

confidence: 99%

Section: Role Of Monocytes and Macrophages In Pregnancy Complicationsmentioning

confidence: 99%

Monocytes and macrophages in pregnancy: The good, the bad, and the ugly*

True

Blanton

Sureshchandra

et al. 2022

Immunological Reviews

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“…Since TIM-1 has been shown to represent an entry co-factor for a number of viruses causing major diseases in humans [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 39 , 70 ], our findings have a major relevance in terms of public health and should enthuse further dedicated investigations exploiting miR-142 as a biomarker as well as a potential target for novel therapeutic approaches. For instance, in line with these observations, we have previously demonstrated that endothelial miRNAs can be harnessed as reliable biomarkers for cerebrovascular complications of COVID-19 [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

“…TIM-1 has been shown to act as a cell receptor or entry factor for a number of viruses, including Hepatitis A (indeed, another of its nomenclatures is Hepatitis A Virus Cellular Receptor 1; HAVcR1) [ 22 , 23 ], Ebola virus [ 24 , 25 , 26 ], West Nile virus [ 26 ], Lassa virus [ 27 ], Marburg virus [ 28 ], Dengue virus [ 29 , 30 ], Japanese encephalitis virus [ 31 ], Chikungunya virus [ 32 ], and Zika virus [ 33 , 34 ]. Intriguingly, emerging investigations have proposed TIM-1 as a co-factor for the internalization of SARS-CoV-2 in human cells [ 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

miR-142 Targets TIM-1 in Human Endothelial Cells: Potential Implications for Stroke, COVID-19, Zika, Ebola, Dengue, and Other Viral Infections

Kansakar

Gambardella

Varzideh

et al. 2022

IJMS

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T-cell immunoglobulin and mucin domain 1 (TIM-1) has been recently identified as one of the factors involved in the internalization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human cells, in addition to angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), neuropilin-1, and others. We hypothesized that specific microRNAs could target TIM-1, with potential implications for the management of patients suffering from coronavirus disease 2019 (COVID-19). By combining bioinformatic analyses and functional assays, we identified miR-142 as a specific regulator of TIM-1 transcription. Since TIM-1 has been implicated in the regulation of endothelial function at the level of the blood-brain barrier (BBB) and its levels have been shown to be associated with stroke and cerebral ischemia-reperfusion injury, we validated miR-142 as a functional modulator of TIM-1 in human brain microvascular endothelial cells (hBMECs). Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections.

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“…As shown in Fig 3, the attachment depends on the interaction between the viral envelope protein and a receptor. AXL, Tyro3, TIM1 and DC-sign have been identified as receptors allowing ZIKV to infect permissive cells [52,53]. However, further investigation is necessary, because recent results have been disputed [54,55].…”

Section: Pathogenesis Of Zikv Zikv Infection Of Permissive Cellsmentioning

confidence: 99%

Zika Virus Overview: Transmission, Origin, Pathogenesis, Animal Model and Diagnosis

Vue

Tang

2021

Zoonoses

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Zika virus (ZIKV) was first discovered in 1947 in Uganda. ZIKV did not receive substantial attention until Brazil hosted the 2016 Summer Olympic Games, and ZIKV reached a global audience. ZIKV is a flavivirus transmitted chiefly through mosquito bites, sexual intercourse and, to a lesser extent, breastfeeding. The recent discovery of how ZIKV causes congenital neurodevelopmental defects, including microcephaly, has led to reevaluation of the importance of the interaction of ZIKV with centrosome organization, because centrosomes play an important role in cell division. When ZIKV disrupts centrosome organization and mitotic abnormalities, neural progenitor differentiation is altered, thereby resulting in cell cycle arrest, increased apoptosis and inhibition of neural progenitor cell differentiation; subsequently, abnormalities in neural cell development can result in microcephaly. To aid in the understanding of the importance of ZIKV infection, this review article provides an overview of its history, transmission routes, pathogenesis, animal models and diagnosis.

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TAM and TIM receptors mRNA expression in Zika virus infected placentas

Cited by 10 publications

References 25 publications

Monocytes and macrophages in pregnancy: The good, the bad, and the ugly*

Monocytes and macrophages in pregnancy: The good, the bad, and the ugly*

miR-142 Targets TIM-1 in Human Endothelial Cells: Potential Implications for Stroke, COVID-19, Zika, Ebola, Dengue, and Other Viral Infections

Zika Virus Overview: Transmission, Origin, Pathogenesis, Animal Model and Diagnosis

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