TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human

Delalande, Jean Marie; Nagy, Nándor; McCann, Conor; Natarajan, Dipa; Cooper, Jayne; Carreno, Gabriela; Dóra, Dávid; Campbell, Alison M.; Laurent, Nicole; Kemos, Polychronis; Thomas, Sophie; Alby, Caroline; Attié‐Bitach, Tania; Lyonnet, Stanislas; Logan, Malcolm; Goldstein, Allan M.; Davey, Megan; Hofstra, Robert M.W.; Thapar, Nikhil; Burns, Alan J.

doi:10.3389/fnmol.2021.757646

Cited by 3 publications

(1 citation statement)

References 114 publications

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“…These range from in vivo studies in different genetically engineered animal models to the application of in vivo imaging techniques (eg, optogenetics) to facilitate the monitoring of neuronal and glial function (21). Ex vivo analyses of tissue or cell cultures (general, eg, from dissociated gut or selective, eg, ENS only) or generated organoids are likely to allow for easier quantitative or functional (eg, electrophysiological, calcium imaging) analyses of neuromuscular components (eg, ENS) (22,23). Organ bath tissue contractility testing does hold promise for clinical utility to better understand and classify intestinal motility disorders.…”

Section: Improved Investigation Of Motility Disordersmentioning

confidence: 99%

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Chanpong

Thapar

2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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The field of pediatric neurogastroenterology and motility encompasses some of the most common and severe gastrointestinal (GI) disorders that affect children. GI motility disorders remain, in general, poorly understood, variably diagnosed, and inadequately treated. Although the field progressed relatively slowly over the last decades, the coming years will, no doubt, see it move into a prolific and dynamic era. With this review, we look forward to this brighter future for the field and highlight emerging areas that show promise and deserve focus in the coming years. This includes the role of early life programming and insult of the enteric neuromusculature as a key determinant of motility diseases and factors that are likely to be relevant in disease etiopathogenesis. We discuss several recent and futuristic developments and advancements in investigative and diagnostic tools as well as novel approaches that have been introduced in the management of GI motility disorders. These include targeted and personalized medicine in both pharmacological and multidisciplinary approaches as well as the emerging therapeutic options such as bioelectrical neuromodulation and regenerative medicine.

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Section: Improved Investigation Of Motility Disordersmentioning

confidence: 99%

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Chanpong

Thapar

2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Physical organogenesis of the gut

Chevalier

2022

Development

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The gut has been a central subject of organogenesis since Caspar Friedrich Wolff’s seminal 1769 work ‘De Formatione Intestinorum’. Today, we are moving from a purely genetic understanding of cell specification to a model in which genetics codes for layers of physical–mechanical and electrical properties that drive organogenesis such that organ function and morphogenesis are deeply intertwined. This Review provides an up-to-date survey of the extrinsic and intrinsic mechanical forces acting on the embryonic vertebrate gut during development and of their role in all aspects of intestinal morphogenesis: enteric nervous system formation, epithelium structuring, muscle orientation and differentiation, anisotropic growth and the development of myogenic and neurogenic motility. I outline numerous implications of this biomechanical perspective in the etiology and treatment of pathologies, such as short bowel syndrome, dysmotility, interstitial cells of Cajal-related disorders and Hirschsprung disease.

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CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum

et al. 2023

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The gastrointestinal tract is innervated by an intrinsic neuronal network, known as the enteric nervous system (ENS), and by extrinsic axons arising from peripheral ganglia. The nerve of Remak (NoR) is an avian-specific sacral neural crest-derived ganglionated structure that extends from the cloaca to the proximal midgut and, similar to the pelvic plexus, provides extrinsic innervation to the distal intestine. The molecular mechanisms controlling extrinsic nerve fiber growth into the gut is unknown. In vertebrates, CXCR4, a cell surface receptor for the CXCL12 chemokine, regulates migration of neural crest cells and axon pathfinding. We have employed chimeric tissue recombinations and organ culture assays to study the role of CXCR4/CXCL12 molecules in development of colorectal innervation. CXCR4 is specifically expressed in nerve fibers arising from the NoR and pelvic plexus, while CXCL12 is localized to the hindgut mesenchyme and enteric ganglia. Overexpression of CXCL12 results in significantly enhanced axonal projections to the gut from the NoR, while CXCR4 inhibition disrupts nerve fiber extension, supporting a novel role for CXCR4/CXCL12 signaling in extrinsic innervation of the colorectum.

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TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human

Cited by 3 publications

References 114 publications

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future

Physical organogenesis of the gut

CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum

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