Tall cell carcinoma with reversed polarity of breast: Sonographic and magnetic resonance imaging findings

Abstract

Tall cell carcinoma with reversed polarity (TCCRP) of breast is a rare subtype of breast cancer, which show tall and columnar cells with nuclei of reversed polarity, resembles tall cell variant in papillary thyroid cancer. Only 78 cases in 20 published studies had been reported by 2021. TCCRP was recently included as a separate subgroup of rare tumors in the World Health Organization Blue Book Classification of breast tumors (5th edition). We describe a TCCRP case in a 64‐year‐old woman with detailed radiologic features including quantitative ultrasonography.

A New Subtype of Papillary Ductal Carcinoma in Situ with Tall Cell and Reversed Polarity Morphology: A Rare Case

“…TCCRP has been considered to be an invasive tumor with only a few cases reported as carcinoma in situ (still controversial due to improper IHC tests) [1,2,[4][5][6][7][8][9][10][11][12][13][14][15]. In addition, this tumor is underpinned by recurrent nding of IDH2 (hot spot mutations in residue 172) mutations accompanied with genetic alterations in the PI3K signaling pathway, especially PIK3CA [1,16,17].…”