“…Several strategies can be applied to patients with multiple myeloma to minimize the disease's complications (MELO et al, 2005). Significant advances include the prevention and treatment of hypercalcemia and bone injuries, pain control, and, in some cases, a decrease in the incidence of pathological fractures (BITTENCOURT et al, 2004;ACQUAH et al, 2019). In the evolution of multiple myeloma, neoplastic lesions are initially restricted to bone and bone marrow, with late extramedullary involvement; this behavior reflects the natural history of B-cell neoplasia, with preliminary involvement of lymph nodes and bone marrow and subsequent dissemination to other organs and skin (SOUSA et al, 2019).…”