“…The gene encoding TFIID has recently been cloned from a variety of organisms, making it feasible to address some of the questions concerning the mechanism of transcriptional stimulation by upstream activators. A comparison of the TFHD sequences from Saccharomyces cerevisiae (Cavallini et al, 1989;Hahn et al, 1989;Horikoshi et al, 1989;Schmidt et al, 1989b), Schizosaccharomyces pombe (Fikes et al, 1990;Hoffmann et al, 1990b), Drosophila (Hoey et al, 1990), Arabidopsis (Gasch et al, 1990) and human (Hoffmann et al, 1990a; Kao et al, 1990;Peterson et al, 1990) indicates that the protein is composed of a highly divergent amino terminus of varying length, and a very conserved carboxy terminus of -180 amino acid residues. For S. cerevisiae TFIID (YIID), the conserved domain begins at residue 61.…”