Talc Functionality as Lubricant: Texture, Mean Diameter, and Specific Surface Area Influence

Ribet, J.L.; Poret, K.; Arseguel, Didier; Chulia, Dominique; Rodriguez, Frédéric

doi:10.1081/ddc-120025870

Cited by 17 publications

(7 citation statements)

References 6 publications

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“…The abrasiveness of quartz causes higher friction between particles and consequently higher SDS foaming (Kulu et al, 2009; West, 1986). While talc is a hydrophobic soft mineral and it is considered a lubricant material (Abdulkareem et al, 2010; Ribet et al, 2003; Tarasevich & Aksenenko, 2014; Yi et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Foam in grinding and role of ground mineral in its stability

El‐Midany,

Farag

2023

J Surfact & Detergents

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Surfactants are usually used as grinding aids. However, surfactant foaming during the grinding process is rarely mentioned in the literature with no clarification of its effect on the grinding process. In this paper, the generation of foam during the grinding of talc and quartz, as two different minerals in their hardness and hydrophobicity, was observed in the presence of sodium dodecyl sulfonate (SDS). The effect of generated foam on the fineness of ground product under different grinding conditions such as solids%, grinding time, and pulp pH was investigated. The results indicated that the foam was formed during the grinding of both minerals. The foam volume depends not only on the presence of surfactant but also on the characteristics of the mineral along with grinding conditions. The foam was intense and more stable particularly at pH 10 and high solid content (i.e., 60% solids) in the case of talc due to its fineness and hydrophobicity that result in bubbles stabilization. Remarkably, there is no foam at acidic pH due to the high ionic strength that leads to bubble instability. Most importantly, the presence of surfactant foams improves the size reduction process by providing more dispersion of particles, as one of the grinding aid mechanisms, due to particle‐particle and particle‐SDS repulsive electrostatic forces.

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Section: Resultsmentioning

confidence: 99%

Foam in grinding and role of ground mineral in its stability

El‐Midany,

Farag

2023

J Surfact & Detergents

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“…Proposed working mechanisms for anticaking agents include (1) competing with the host substance for the moisture, (2) forming a protective moisture barriers on the surface of the particle, (3) decreasing the point of contacts between the particles, and (4) inhibiting crystal growth in solid bridge formation. [32][33][34] In a pharmaceutical context, talc is acting as a lubricant and decreases the contact points between the host particles, 35,36 thereby preventing solid bridge formation. By storing all samples simultaneously, it was possible to limit the variations in the results.…”

Section: Investigating Control Strategies For Avoiding Cakingmentioning

confidence: 99%

Expedited Investigation of Powder Caking Aided by Rapid 3D Prototyping of Testing Devices

Hirschberg

Boetker

Risbo

et al. 2020

Journal of Pharmaceutical Sciences

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Powder caking can dramatically affect powder handling and downstream production processes. Understanding the key factors that contribute to bulk powder caking is crucial. This article introduces the Hirschberg caking device (HCD), which is a 3D-printed device allowing for parallel testing of powder caking in a cylindrical geometry. In the HCD setup, the powder sample is stored in controlled conditions in the sample holder. On removal of the sample holder, the caked powder will remain in the shape determined by the sample geometry while the remaining powder will fall down. Caking indices can be calculated based on image analysis and weight measurement. The results obtained for the caking of lactose monohydrate with the HCD were in good agreement with the results obtained by a ring shear tester. In addition, a strain tester was used to measure the strength of the formed cakes. Using this approach, critical storage conditions and the required concentration of a given anticaking agent (talc) for lactose monohydrate could be identified. This work demonstrates the potential of rapid prototyping in powder characterization by introducing a fast and affordable approach for exploring and trouble-shooting powder caking.

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“…On the other hand, the average hardness value for Formulation 3 was relatively lower at 74 N. This could be attributed to the presence of talc in the formulation which might result in reduced cohesion between ingredients. [17] Tablets disintegration Large variability was observed during disintegration testing of the formulations. Compressed amoxicillin tablets, Formulation 1, disintegrated in 2 h which is considered a very long time and way above the required pharmacopeial limit for tablets/capsules and coated tablets.…”

Section: Tablets Friabilitymentioning

confidence: 99%

The redesign of amoxicillin capsules as a tablet dosage form using direct compression

Elgahmi

Alrishei

Algaraboly

et al. 2019

Libyan International Medical University Journal

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Introduction: Solid dosage forms are the most commonly used dosage form for drug delivery, and tablets are more popular than capsules because of its lower production cost, minimal potential of content tampering, and the large number of designs of tablets for various applications. Aims: The aim of this work is to redesign amoxicillin hard gelatin capsules (HGCs), commonly filled into HGCs, into tablet dosage form by employing preformulation principles. Materials and Methods: Amoxicillin capsules were obtained from the local market for this purpose. Experiments included studies on flowability and effect of compression force, followed by addition of excipients, production of tablets by direct compression, and evaluation employing standard methods of friability, hardness, disintegration, dissolution, and simulation of release kinetics. Results: The flowability of powder was estimated using Carr's index, Hausner ratio, angle of repose, and bulk density. The flowability was found poor for amoxicillin alone or with starch but improved with talc. Compression force was found to be a significant factor on friability, hardness, and disintegration. The disintegration time was rapid in case of tablets containing starch compared to amoxicillin powder compressed alone. It was essential to include small amounts of disintegrant and a lubricant to optimize tablet properties. Dissolution rates for the prepared tablets were found to be acceptable, while some formulations showed a slow release profiles corresponding to their slow disintegration. Release kinetics was found to follow both the zero-order and matrix models. Conclusion: Amoxicillin capsules can be modified to a tablet dosage form with simple handling of preformulation properties.

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Talc Functionality as Lubricant: Texture, Mean Diameter, and Specific Surface Area Influence

Cited by 17 publications

References 6 publications

Foam in grinding and role of ground mineral in its stability

Foam in grinding and role of ground mineral in its stability

Expedited Investigation of Powder Caking Aided by Rapid 3D Prototyping of Testing Devices

The redesign of amoxicillin capsules as a tablet dosage form using direct compression

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