Talc and Carcinoma of the Ovary and Cervix

Henderson, W.; Joslin, C. A.; Griffiths, K.; Turnbull, A. C.

doi:10.1111/j.1471-0528.1971.tb00267.x

Cited by 95 publications

(42 citation statements)

References 8 publications

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“…This banding is visible only on the electron translucent fibers. Some workers have called these bands decoration patterns in reference to similar diffraction contrast features observed on sheet silicates, especially talc (11). Diffraction contrast figures have been observed on all amphibole fiber types.…”

Section: Morphology Of Amphibole Asbestos Fibersmentioning

confidence: 98%

Electron Microscopical Investigation of Asbestos Fibers

Langer¹,

Mackler²,

Pooley³

1974

Environmental Health Perspectives

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Examination of asbestos fibers by electron microscopical techniques enables the observer to distinguish among the fiber types by morphological and structural characteristics.Chrysotile asbestos fibers are composed of bundles of fibrils. Fibers are often curvilinear with splayed ends. Individual fibrils consist of a central capillary defined by an electron dense crystalline wall. With increasing time of electron bombardment, the capillary wail decreases in thickness, deforms, and is encapsulated in an electron translucent material. The change in electron opacity is considered to be a product of structural disruption brought about by dehydroxylation due to electron radiation. A well recognized sequential deformation pattern may be used for identification purposes.Amphibole fibers tend to be straight, splintery, and electron-opaque, although curved fibers are occasionally observed. Diffraction contrast figures are visible as dark bands moving parallel and at right angles to the fiber axis. Crocidolite forms the shortest and thinnest fibers, followed in size by amosite and anthophyllite. Size distribution characteristics of the amphibole fiber types are different.The selected area electron diffraction pattern for chrysotile is unique. Reflections range in forms from streaked to arcuate. Reflection intensity and shape are related to the degree of openness of the fiber bundle and the extent of physical degradation of the fiber. The amphibole asbestos fibers possess diffraction patterns having similar characteristics prohibiting individual identification. Microchemical analysis is required for identification in such cases.A discussion of the industrial hygiene threshold limit values for ampliphibole asbestos fibers is presented. The discussion is based on their differing size distribution characteristics.

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Section: Morphology Of Amphibole Asbestos Fibersmentioning

confidence: 98%

Electron Microscopical Investigation of Asbestos Fibers

Langer¹,

Mackler²,

Pooley³

1974

Environmental Health Perspectives

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“…1 In animal studies, talc and other similar substances have been demonstrated to migrate from the vagina through the peritoneal cavity to the ovaries. 2 Henderson et al 3 also observed that particles with the appearance of talc were more prevalent in ovarian tumors than in normal ovarian tissue. Several epidemiologic studies have investigated perineal use of talcum powder as a potential risk factor for ovarian cancer and most have found elevations in risk, although there has been a large range in the risk estimates, from 1.1 to 3.9.…”

mentioning

confidence: 91%

Perineal talc exposure and epithelial ovarian cancer risk in the Central Valley of California

Mills

Riordan

Cress³

et al. 2004

Intl Journal of Cancer

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“…Appraisal of the carcinogenicity of talc is important as it has been suggested that prolonged exposure to talc, with or without asbestos contamination, may be associated with malignant changes (Henderson et al, 1971;Merliss, 1971;Blejer and Arlon, 1973;Pelfrene and Shubik, 1975), and that fibrous particles with specific dimensions may be carcinogenic (Stanton and Wrench, 1972;Maroudas et al, 1973). Pott and Friedrichs (1972) In a study in hamsters (Smith et al, 1965;Smith, 1973) 25 mg of test dusts dispersed in 0-5 ml saline were administered intrapleurally to groups of 50 animals which were allowed to live their normal life spans.…”

Section: Cancer Studies In Animalsmentioning

confidence: 99%

“…Exposure to some mineral dusts in appropriate amounts can cause pneumoconiosis and in some instances can be associated with the development of cancer (Henderson et al, 1971;Murphy et al, 1971;British Medical Journal, 1973;Wagner et al, 1973). There is a possibility that talc alone or talc contaminated with asbestos may be associated with cancer formation (Merliss, 1971;Blejer and Arlon, 1973), although cancer has not so far been reported from its use therapeutically in the pleural cavity (Honma et al, 1963) or accidental introduction into the abdominal cavity from ruptured surgeons' gloves.…”

Section: Cancermentioning

confidence: 99%

See 1 more Smart Citation

The biology of talc.

Hildick‐Smith¹

1976

Occupational and Environmental Medicine

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-229. The biology of talc. Data are presented on the effects on health of talc dusts from exposure in industry and use of talc-containing health products. The mineralogy of talc and the composition of cosmetic and industrial grade talc dusts are described. Studies in animals are reviewed, and epidemiological data are considered in relation to exposures that occur during industrial and consumer uses of talc dusts. Hamsters exposed to 8 mg/m3 of respirable cosmetic grade talc dust for up to 150 minutes a day for 300 consecutive days showed no difference in incidence or nature of pathological lesions from those observed in a group of untreated animals. A retrospective study of the causes of death of 227 talc mine millers exposed to cosmetic grade talc at the threshold limit value for talc (20 million parts per cubic foot) for an average of 15 8 years showed that the causes of death were no different from those in a control cohort not exposed to talc dust. The available data indicate that talc dust exposure in the modern mining of cosmetic grade talc does not appear to be injurious to health. The significantly lower dust exposure in the normal use of cosmetic grade talc dusts in talc-containing health and cosmetic products confirms that their use is not a hazard to health.Increasing interest in the impact of environmental influences on health has in recent years focused attention on the significance of pollutants and prompted a reappraisal of environmental mineral dusts that have had extensive long-term use, but on which there is a paucity of correlated scientific data by which to

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Talc and Carcinoma of the Ovary and Cervix

Abstract: Summary An extraction‐replication technique was used to examine tissue from patients with ovarian and cervical tumours. In both conditions talc particles were found deeply embedded within the tumour tissue. The close association of talc to the asbestos group of minerals is of interest.

Cited by 95 publications

References 8 publications

Electron Microscopical Investigation of Asbestos Fibers

Electron Microscopical Investigation of Asbestos Fibers

Perineal talc exposure and epithelial ovarian cancer risk in the Central Valley of California

The biology of talc.

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