Talaromycosis clinically and histopathologically mimicking histoplasmosis in an immunocompromised patient

Widaty, Sandra; Santoso, Irene Dorthy; Ricky,; Yunihastuti, Evy; Rihatmadja, Rahadi; Wahyuningsih, Retno

doi:10.5070/d3269050160

Cited by 5 publications

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References 15 publications

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“…Histologically, the transverse septum within the yeast cell is the most distinguishable feature of T. marneffei (Vanittanakom et al, 2006). However, with hematoxylin and eosin staining, yeast cells with the characteristic septated structure are usually difficult to identify on the background of infiltrations of neutrophils, lymphocytes and histiocytes (Figure 3B), which makes it hard to distinguish T. marneffei from Histoplasma capsulatum (Widaty et al, 2020). In contrast, once stained with PAS or GMS, especially GMS, yeast cells with transverse septa can have been more easily appreciated in histological observation (Figures 3C,D).…”

Section: Discussionmentioning

confidence: 99%

Case report: Acute Talaromyces marneffei mediastinitis in an HIV-negative patient

et al. 2022

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Talaromyces marneffei (T. marneffei) is one of the most important opportunistic human pathogens endemic in Southeast Asia. Talaromycosis, which was once regarded as an opportunistic infectious disease in patients with acquired immunodeficiency syndrome, is being increasingly reported in HIV-negative populations. Since T. marneffei infection can be localized or disseminated, patients may present with a variety of symptoms. However, mediastinal infection attributed to T. marneffei is extremely rare. We report the case of a 32-year-old female who manifested a large mediastinal mass and was eventually diagnosed as acute T. marneffei mediastinitis. The patient was HIV-negative and had no direct contact with intermediate hosts. We successfully managed to treat the patient with inhaled amphotericin B deoxycholate and observed lesion absorption in subsequent CT examinations. To our knowledge, this is the first published case of T. marneffei mediastinitis and first use of inhaled antifungal monotherapy on patients with T. marneffei infection.

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Section: Discussionmentioning

confidence: 99%