Talaromyces atroroseus in HIV and non-HIV patient: A first report from Indonesia

Surja, Sem Samuel; Adawiyah, Robiatul; Houbraken, Jos; Rozaliyani, Anna; Sjam, Ridhawati; Yunihastuti, Evy; Wahyuningsih, Retno

doi:10.1093/mmy/myz090

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…Assumed to be 1% in advanced HIV disease National Baker, 2019 72 Talaromycosis Assumed to be 0.2% in advanced HIV disease National Surja et al 2020 86 Widaty et al 2020 Candida peritonitis Post-surgical Candida peritonitis is 50% of the ICU-related candidaemia annual rate.…”

Section: Pneumocystis Pneumoniamentioning

confidence: 99%

Serious fungal disease incidence and prevalence in Indonesia

Wahyuningsih

Adawiyah

Sjam

et al. 2021

Mycoses

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Background Indonesia is a tropical country, warm and humid, with numerous environmental fungi. Data on fungal disease burden help policymakers and clinicians. Objectives We have estimated the incidence and prevalence of serious fungal diseases. Methods We found all published and unpublished data and estimated the incidence and prevalence of fungal diseases based on populations at risk. HIV data were derived from UNAIDS (2017), pulmonary tuberculosis (PTB) data from 2013–2019, data on chronic pulmonary aspergillosis (CPA) were used to estimate CPA prevalence and likely deaths, COPD data from Hammond (2020), lung cancer incidence was from Globocan 2018, and fungal rhinosinusitis was estimated using community data from India. Results Overall ~7.7 million Indonesians (2.89%) have a serious fungal infection each year. The annual incidence of cryptococcosis in AIDS was 7,540. Pneumocystis pneumonia incidence was estimated at 15,400 in HIV and an equal number in non‐HIV patients. An estimated 1% and 0.2% of new AIDS patients have disseminated histoplasmosis or Talaromyces marneffei infection. The incidence of candidaemia is 26,710. The annual incidence of invasive aspergillosis was estimated at 49,500 and the prevalence of CPA is at 378,700 cases. Allergic bronchopulmonary aspergillosis prevalence in adults is estimated at 336,200, severe asthma with fungal sensitisation at 443,800, and fungal rhinosinusitis at 294,000. Recurrent vulvovaginal candidiasis is estimated at 5 million/year (15–50 years old). The incidence of fungal keratitis around 40,050. Tinea capitis prevalence in schoolchildren about 729,000. Conclusions Indonesia has a high burden of fungal infections.

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Section: Pneumocystis Pneumoniamentioning

confidence: 99%

Serious fungal disease incidence and prevalence in Indonesia

Wahyuningsih

Adawiyah

Sjam

et al. 2021

Mycoses

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“…Thus, based on morphological identification alone, we were able to prove that the fungi isolated from the skin lesions were H. capsulatum and Talaromyces sp. Both fungi were then analyzed using a molecular method, and the Talaromyces species was found to be Talaromyces atroroseus (Surja et al, 2020), while the Histoplasma species was confirmed to be H. capsulatum (data not shown).…”

Section: Resultsmentioning

confidence: 99%

Touch Biopsy: A Simple and Rapid Method for the Diagnosis of Systemic Mycoses with Skin Dissemination in HIV-Infected Patients

Wahyuningsih¹,

Adawiyah²,

Hoemardani³

et al. 2021

IJTech

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Systemic fungal infection can disseminate to the skin and require prompt treatment, making early diagnosis very important. This study describes the use of a simple, quick touch biopsy method for the diagnosis of invasive mycoses in patients with AIDS with cutaneous manifestations. We identified fungal infections in 24 of the 29 investigated patients. Histoplasma capsulatum, Cryptococcus neoformans, Talaromyces artroroseus, Aspergillus flavus, Candida tropicalis, and Malassezia sp. were visualized directly in samples obtained from cutaneous lesions and confirmed by culture and molecular examination. The results suggested that touch biopsy is a simple, rapid method for the diagnosis of systemic mycoses with skin dissemination. It can be performed using simple tools and provides quick results, allowing for early intervention with appropriate antifungal therapy.

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“…Talaromyces marneffei infection is also reported from HIV-infected individuals in Southeast Asia [2]. It is worth noting that a newer species known as Talaromyces atroroseus, which has a different pattern of antifungal susceptibility to T. marneffei, was reported in AIDS patients [14]. Emergomyces africanus, Emergomyces orientalis, and Emergomyces pasteurianus are 3 dimorphic fungal species that cause emergomycosis.…”

Section: Covid-19 and Aids-related Mycosesmentioning

confidence: 99%

The impact of COVID-19 pandemic on AIDS-related mycoses and fungal neglected tropical diseases: Why should we worry?

2021

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The World Health Organization (WHO) considers mycetoma, chromoblastomycosis, and paracoccidioidomycosis to be fungal neglected tropical diseases (FNTDs). Depending on climatic, cultural, and economic contexts, these diseases have a similar geographical distribution as many other diseases, particularly tuberculosis (TB) and malaria, but are often less targeted by the national and many international healthcare systems. Another subgroup of fungal infections, such as candidiasis, cryptococcosis, pneumocystosis, histoplasmosis, and to a lesser extent, aspergillosis, are known as AIDS-related mycoses. Although antiretroviral therapy (ART) has been able to decrease the mortality rate of these diseases, particularly cryptococcosis, the disproportionately low distribution of funds to their diagnosis and treatment remains an obstacle in saving and improving the lives of patients affected. A new wave of viral diseases dubbed the Coronavirus Disease 2019 (COVID-19) hit the world at the end of 2019. Due to progressive symptoms and high mortality rates of COVID-19 compared to fungal infections, particularly the FNTDs, funding is currently allocated predominantly for diagnostic and therapeutic research on COVID-19. As a result, advances in FNTDs and AIDS-related mycosis care are considerably reduced. This paper explores the association between COVID-19, FNTDs, and AIDS-related mycoses with a predictive perspective.

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Talaromyces atroroseus in HIV and non-HIV patient: A first report from Indonesia

Cited by 5 publications

References 15 publications

Serious fungal disease incidence and prevalence in Indonesia

Serious fungal disease incidence and prevalence in Indonesia

Touch Biopsy: A Simple and Rapid Method for the Diagnosis of Systemic Mycoses with Skin Dissemination in HIV-Infected Patients

The impact of COVID-19 pandemic on AIDS-related mycoses and fungal neglected tropical diseases: Why should we worry?

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