Talamotomia e palidotomia estereotáxica com planejamento computadorizado no tratamento da doença de Parkinson: avaliação do desempenho motor a curto prazo de 50 pacientes

Ferraz, Fernando Antônio Patriani; Aguiar, Patrícia M. C.; Ferraz, Henrique Ballalai; Bidó, José O.; Bouza, Armando A.; Andrade, Luiz Augusto Franco de

doi:10.1590/s0004-282x1998000500014

Cited by 9 publications

(13 citation statements)

References 24 publications

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“…All bilateral procedures were performed simultaneously. The surgical methods have been described in detail elsewhere 18 .…”

Section: Methodsmentioning

confidence: 99%

Motor performance after posteroventral pallidotomy and VIM-thalamotomy in Parkinson's disease: a 1-year follow-up study

Aguiar

Ferraz

et al. 2000

Arq. Neuro-Psiquiatr.

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-Twenty-three patients with Parkinson's disease underwent stereotactic surgery. To study the long-term motor performance, the patients were evaluated at the pre-operative period and at the 1 st , 3 rd , 6 th , and 12 th post-operative months, with the following scales: Unified Parkinson's Disease Rating Scale (UPDRS) motor score and Larsen's Scale for Dyskinesias. The patients under levodopa therapy were assessed both in "on" and "off" periods. Fourteen unilateral ventrolateral thalamotomies (VLT), 4 unilateral posteroventral pallidotomies (PVP), 2 bilateral PVP, and 3 VLT with contralateral PVP were performed. The motor improvement was significant and long-lasting in the "off" period, except for 2 patients. The "on" period quality improved, mainly due to the control of dyskinesias. The improvement of dyskinesias was long-lasting for the majority of the patients. There was no significant decrease in the levodopa dose. Three patients showed permanent complications, but none was severe.KEY WORDS: Parkinson's disease, thalamotomy, pallidotomy.Desempenho motor após palidotomia póstero-ventral e talamotomia ventro-lateral na doença de Parkinson: acompanhamento de um ano RESUMO -Vinte e três pacientes portadores de doença de Parkinson foram submetidos a cirurgia estereotáxica para tratamento da doença. Com o objetivo de estudar o desempenho motor a longo prazo, os pacientes foram avaliados clinicamente no período pré-operatório, no 1°, 3°, 6°, e 12° mês pós-operatório, com as seguintes escalas: Escala Unificada para Doença de Parkinson (Unified Parkinson's Disease Rating Scale-UPDRS), item III, escore motor e com a Escala de Larsen para Discinesias. Os pacientes que utilizavam levodopa foram avaliados nos estados "off" e "on". Foram realizadas 14 talamotomias ventro-laterais (TVL) unilaterais, 4 palidotomias póstero-ventrais (PPV) unilaterais, 2 PPV bilaterais; 3 TVL associadas à PPV contralateral. O benefício motor foi observado de forma significante no estado "off", e manteve-se a longo prazo na maioria dos pacientes, exceto em 2. Houve melhora da qualidade do período "on", devido ao controle das discinesias. A melhora das discinesias se manteve a longo prazo na maioria dos pacientes. As cirurgias não promoveram um decréscimo significante na dose de levodopa.Três pacientes tiveram complicações permanentes, mas nenhuma delas foi considerada grave e nem houve prejuízo funcional importante em decorrência das mesmas. PALAVRAS-CHAVE: doença de Parkinson, talamotomia, palidotomia.Levodopa remains the goldstandard treatment for patients with Parkinson's disease (PD). However, after some years, part of these patients develop complications related to the prolonged use of the drug, such as fluctuations and disabling dyskinesias 1 . In the absence of satisfactory pharmacological therapy, there has been a resurgence of interest for stereotactic surgery in the last

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“…All bilateral procedures were performed simultaneously. The surgical methods have been described in detail elsewhere 18 .…”

Section: Methodsmentioning

confidence: 99%

Motor performance after posteroventral pallidotomy and VIM-thalamotomy in Parkinson's disease: a 1-year follow-up study

Aguiar

Ferraz

et al. 2000

Arq. Neuro-Psiquiatr.

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“…A summary of mortality and morbidity events for the two methods of pallidotomy is presented in Table 2. Incidences of mortality and morbidity following microelectrode recording [2][3][4][5][6]11,21,32,34,38,42,45,49,51,55,58,61,62,64 and macrostimulation 7,8,12,14,18,23,27,28,30,31,33,36,37,39,46,56,57 were tabulated. Morbidity events were categorized as intracranial hemorrhage, persistent visual deficit (lasting Ͼ 3 months), persistent speech deficit (dysarthria, dysphasia, or hypophonia), persistent cognitive decline, persistent weakness (facial or limb hemiparesis), or other rare problems (seizure, infarction, infection, abandon-ment of the procedure, or a persistent neurological deficit not included earlier).…”

Section: Measurements Of Outcomes and Complicationsmentioning

confidence: 99%

A metaanalysis comparing the results of pallidotomy performed using microelectrode recording or macroelectrode stimulation

Palur

Berk²,

Schulzer³

et al. 2002

Journal of Neurosurgery

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Object. There is an active debate regarding whether pallidotomy should be performed using macroelectrode stimulation or the more sophisticated and expensive method of microelectrode recording. No prospective, randomized trial results have answered this question, although personnel at many centers claim one method is superior. In their metaanalysis the authors reviewed published reports of both methods to determine if there is a significant difference in clinical outcomes or complication rates associated with these methods. Methods. A metaanalysis was performed with data from reports on the use of unilateral pallidotomy in patients with Parkinson disease (PD) that were published between 1992 and 2000. A Medline search was conducted for the key word “pallidotomy” and additional studies were added following a review of the references. Only those studies dealing with unilateral procedures performed in patients with PD were included. Papers were excluded if they described a cohort smaller than 10 patients or a follow-up period shorter than 3 months or included cases that previously had been reported. The primary end points for outcome were the percentages of improvement in dyskinesias and in motor scores determined by the Unified PD Rating Scale (UPDRS). Complications were categorized as mortality, intracranial hemorrhage, visual deficit, speech deficit, cognitive decline, weakness, and other. There were no significant differences between the two methods with respect to improvements in dyskinesias (p = 0.66) or UPDRS motor scores (p = 0.62). Microelectrode recording was associated with a significantly higher (p = 0.012) intracranial hemorrhage rate (1.3 ± 0.4%), compared with macroelectrode stimulation (0.25 ± 0.2%). Conclusions. In reports of patients with PD who underwent unilateral pallidotomy, operations that included microelectrode recording were associated with a small, but significantly higher rate of symptomatic intracranial hemorrhage; however, there was no difference in postoperative reduction of dyskinesia or bradykinesia compared with operations that included macroelectrode stimulation.

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“…A TVL é indicada nos casos onde há predomínio da rigidez e do tremor [20][21][22][23][24] . Nosso estudo assemelha-se muito com o de Ferraz et al 25 , quanto à técnica cirúrgica e escolha do alvo cirúrgico. Na análise da variação da dose de levodopa por paciente com DP no período pré-operatório, 12º e 24º mês, após o procedimento cirúrgico, observamos que não houve modificação estatísticamente significante na dose de levodopa utilizada pelos pacientes antes e depois da cirurgia (Fig 2).…”

Section: Discussionunclassified

Avaliação das atividades da vida diária dos pacientes com doença de Parkinson submetidos a cirurgia estereotáxica

Pinto

Borges

Aguiar

et al. 2002

Arq. Neuro-Psiquiatr.

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RESUMO -Objetivo: Avaliar o impacto da cirurgia estereotáxica sobre a realização das atividades da vida diária dos paciente com doença de Parkinson (DP). Método: Foram avaliados 30 pacientes com DP forma idiopática submetidos a cirurgia estereotáxica nos períodos pré-operatório, 1º, 3º, 6º e 12º mês pós-operatório, segundo as escala UPDRS -Item II (escala unificada para DP), Schwab & England e Hoehn & Yahr. Destes, nove pacientes foram também avaliados no 24º mês pós-operatório. Resultados: Foram realizadas nove palidotomias póstero-ventrais (PPV), sendo duas à esquerda e sete à direita; duas PPV bilaterais no mesmo tempo cirúrgico; 17 talamotomias ventro-laterais (TVL), sendo 12 à esquerda e cinco à direita; duas TVL à esquerda com PPV à direita no mesmo tempo cirúrgico. Os escores médios, na fase off, das escalas utilizadas foram: 65,6 no pré-operatório,74 no 1º mês, 76,6 no 3º mês, 75,6 no 6º mês e 72,3 no 12º mês pós-operatório (Schwab & England); 21 no pré-operatório, 12,3 no 1º mês, 14,7 no 3º mês, 15,27 no 6º mês e 17,1 no 12º mês pós-operatório (UPDRS); 3,1 no pré-operatório, 2,8 no 1º mês, 2,7 no 3º mês, 2,8 no 6º mês e 2,85 no 12º mês pós-operatório (Hoehn & Yarh). Conclusão: A TVL e a PPV são procedimentos capazes de melhorar a independência dos pacientes para realização das atividades cotidianas, sendo constatado benefício maior nos seis primeiros meses de pós-operatório. PALAVRAS-CHAVE: doença de Parkinson, cirurgia estereotáxica, atividades da vida diária.Daily living activities in P Daily living activities in P Daily living activities in P Daily living activities in P Daily living activities in Parkinson's disease patients underwent to stereotactic surgery arkinson's disease patients underwent to stereotactic surgery arkinson's disease patients underwent to stereotactic surgery arkinson's disease patients underwent to stereotactic surgery arkinson's disease patients underwent to stereotactic surgery ABSTRACT -Objective: To evaluate the impact of stereotactic surgery on daily activities of Parkinson's disease (PD) patients. Method: Thirty patients with idiopathic PD were evaluated before surgery and one, three, six and twelve months after surgery. Patients were evaluated with the UPDRS -part II (Unified Parkinson's Disease Rating Scale) and the Schwab & England scales. Nine of the patients had also been evaluated after twenty four months. Results: We performed nine posteroventral pallidotomies (PVP), two on the left hemisphere and seven on the right; 17 ventrolateral thalamotomies (VLT), 12 on the left and five on the right; two VLT on the left associated with PVP on the right at the same surgical procedure. The mean "off" phase scores of Schwab & England scale were: 60.6 before surgery, 74 after the first, 76.6 after the third, 75.6 after the sixth, 72.3 after the twelfth and 71.1 after the twenty fourth months after surgery. The mean "off" phase scores of UPDRS -part II scale were: 21 before surgery, 12.3 after the first, 14.7 after the third, 15.27 after the sixth, 17.1 after the twelfth and 17....

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Talamotomia e palidotomia estereotáxica com planejamento computadorizado no tratamento da doença de Parkinson: avaliação do desempenho motor a curto prazo de 50 pacientes

Cited by 9 publications

References 24 publications

Motor performance after posteroventral pallidotomy and VIM-thalamotomy in Parkinson's disease: a 1-year follow-up study

Motor performance after posteroventral pallidotomy and VIM-thalamotomy in Parkinson's disease: a 1-year follow-up study

A metaanalysis comparing the results of pallidotomy performed using microelectrode recording or macroelectrode stimulation

Avaliação das atividades da vida diária dos pacientes com doença de Parkinson submetidos a cirurgia estereotáxica

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