Takotsubo Syndrome is Associated with Mood Disorders and Antidepressants Use, not with Anxiety and Impairment of Quality of Life Due to the Psychiatric Disorder

Abstract

Background:The aim was to study the association between mood and anxiety disorders and the Tako-Tsubo Syndrome (TTS) and to determine the role of antidepressants and the impairment of quality of life due the comorbid psychiatric disorder.Methods:Case-control study: 19 consecutive patients (17 female) with TTS compared to 76 controls without TTS, were randomly selected from the database of a nationwide epidemiological study after matching (gender, age and residence) by controls. Psychiatric diagnoses were carried out according to the ICD-10 using semi-structured interview tools (ANTAS-SCID) administered by clinical staff. Quality of Life (Qol) was assessed by means of SF-12.Results:Only Major Depressive Disorders (MDD) showed higher frequencies in cases with statistical significance difference (p=0.014) as well as at least one Mood Disorder Diagnosis [MDD or BD] (p=0.002). The lifetime prevalence of at least one anxiety disorder with no comorbid mood disorder did not show a higher frequency in cases (p=0.57).The score at SF-12 in the TTS group was similar to those of controls (p=0.71)In the TTS group, the score at SF-12 in people with one mood or anxiety diagnosis (N=7) was similar to those without mood or anxiety diagnosis (p=0.75). The use of antidepressants was higher in TTS group (15.79% vs 1.31%; p=0.030).Conclusion:The study shows an association between TTS with depressive disorders and antidepressants use and does not confirm the association with anxiety syndromes. The study suggests the need to investigate the possible interactions between antidepressants use and mood disorders in studies with appropriate design and sample size.

Traumatic Events, Personality and Psychopathology in Takotsubo Syndrome: A Systematic Review

“…Anxiety and depression seemed to be prevalent in the history of TTS in one study (Delmas et al, 2013), while two studies evidenced a role only for anxiety (Del Pace et al, 2011;Christensen et al, 2016). Two studies (Smeijers et al, 2016;Sancassiani et al, 2018) evidenced a role for depression (and not for general anxiety) if compared with healthy controls, but not if compared with patients with chronic heart failure (Smeijers et al, 2016). One study (Compare et al, 2018) compared the prevalence of depression in TTS with emotion triggers vs. acute myocardial infarction with emotion triggers vs. TTS without emotion trigger and found a significant prevalence only in the two groups with emotion triggers.…”

“…Eight studies analyzed the presence of past psychopathologic diagnoses by means of psychometric tests after the occurrence of TTS (Del Pace et al, 2011;Delmas et al, 2013;Compare et al, 2014Compare et al, , 2018Kastaun et al, 2014;Christensen et al, 2016;Smeijers et al, 2016;Sancassiani et al, 2018) with miscellaneous findings. Anxiety and depression seemed to be prevalent in the history of TTS in one study (Delmas et al, 2013), while two studies evidenced a role only for anxiety (Del Pace et al, 2011;Christensen et al, 2016).…”

Myocardial contrast echocardiography in the diagnosis of postoperative takotsubo myocardiopathy: case report and literature review

“…In most instances, TCM is observed after emotional or physical stress; a recent paper also suggested an association between TCM and depression/mood disorders [3]. However, TCM can also be related to the stress of surgery, in which case, it is called perioperative TCM (pTCM) [4].…”

How Do Depressive Mood or Antidepressants Acutely Increase Serum Catecholamines?

“…We read with interest the article by Sancassiani et al . about a study of 19 patients with a history of Takotsubo Syndrome (TTS) who underwent psychiatric studies by means of the ANTAS-SCID and the SF-12 tools [1]. The authors found an association between TSS and depressive disorders and the use of antidepressive drugs [1].…”