Takotsubo Syndrome: From Bench to Bedside and Bedside to Bench

Pelliccia, Francesco; Morgantini, Amalia; Rosati, Riccardo

doi:10.3390/jcm11164704

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The investigators, however, could not show if myocardial inflammation was a determinant or only a bystander of the condition [26]. in animal models of TTS, experimental work has demonstrated the occurrence of a regional inflammatory response with an increased concentration of pro-inflammatory macrophages and a reduced availability of anti-inflammatory macrophages that should promote tissue healing [27]. This seems to indicate that sympathetic overreaction results in focal inflammation and intramyocardial edema, that should be interpreted as a form of chemical myocarditis induced by catecholamines [28].…”

Section: Inflammationmentioning

confidence: 98%

Unraveling Pathophysiology of Takotsubo Syndrome: The Emerging Role of the Oxidative Stress’s Systemic Status

Viceconte

Petrella

Pelliccia

et al. 2022

JCM

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Takotsubo Syndrome (TTS) is usually triggered by emotional or physical stressors, thus suggesting that an increased sympathetic activity, leading to myocardial perfusion abnormalities and ventricular dysfunction, plays a major pathogenetic role. However, it remains to be elucidated why severe emotional and physical stress might trigger TTS in certain individuals but not others. Clinical research has been focused mainly on mechanisms underlying the activation of the sympathetic nervous system and the occurrence of myocardial ischemia in TTS. However, scientific evidence shows that additional factors might play a pathophysiologic role in the condition’s occurrence. In this regard, a significant contribution arrived from metabolomics studies that followed the systemic response to TTS. Specifically, preliminary data clearly show that there is an interplay between inflammation, genetics, and oxidative status which might explain susceptibility to the condition. This review aims to sum up the established pathogenetic factors underlying TTS and to appraise emerging mechanisms, with particular emphasis on oxidative status, which might better explain susceptibility to the condition.

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Section: Inflammationmentioning

confidence: 98%

Unraveling Pathophysiology of Takotsubo Syndrome: The Emerging Role of the Oxidative Stress’s Systemic Status

Viceconte

Petrella

Pelliccia

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

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Takotsubo Syndrome and Gender Differences: Exploring Pathophysiological Mechanisms and Clinical Differences for a Personalized Approach in Patient Management

Giubilato,

Francese,

Manes

et al. 2024

JCM

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Takotsubo syndrome (TTS), also known as the broken-heart syndrome, is a reversible condition typically observed in female patients presenting for acute coronary syndromes (ACS). Despite its increasing incidence, TTS often remains undiagnosed due to its overlap with ACS. The pathophysiology of TTS is complex and involves factors such as coronary vasospasm, microcirculatory dysfunction, increased catecholamine levels, and overactivity of the sympathetic nervous system. Diagnosing TTS requires a comprehensive approach, starting with clinical suspicion and progressing to both non-invasive and invasive multimodal tests guided by a specific diagnostic algorithm. Management of TTS should be personalized, considering potential complications, the presence or absence of coronary artery disease (CAD), diagnostic test results, and the patient’s clinical course. The current data primarily derive from case series, retrospective analyses, prospective registries, and expert opinions. In recent years, there has been growing recognition of gender differences in the pathophysiology, presentation, and outcomes of TTS. This review provides an updated overview of gender disparities, highlighting the importance of tailored diagnostic and management strategies.

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Takotsubo Syndrome: From Bench to Bedside and Bedside to Bench

Abstract: Takotsubo syndrome (TTS) typically manifests as acute chest pain and/or dyspnea triggered by intense psychological or physiological stress [...]

Cited by 2 publications

References 15 publications

Unraveling Pathophysiology of Takotsubo Syndrome: The Emerging Role of the Oxidative Stress’s Systemic Status

Unraveling Pathophysiology of Takotsubo Syndrome: The Emerging Role of the Oxidative Stress’s Systemic Status

Takotsubo Syndrome and Gender Differences: Exploring Pathophysiological Mechanisms and Clinical Differences for a Personalized Approach in Patient Management

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