Takotsubo syndrome and estrogen receptor genes

Pizzino, Gabriele; Bitto, Alessandra; Crea, Pasquale; Khandheria, Bijoy K.; Vriz, Olga; Carerj, Scipione; Squadrito, Francesco; Minisini, Rosalba; Citro, Rodolfo; Cusmà-Piccione, Maurizio; Madaffari, Antonio; Andò, Giuseppe; Altavilla, Domenica; Zito, Concetta

doi:10.2459/jcm.0000000000000500

Cited by 26 publications

(25 citation statements)

References 34 publications

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“…The highest risk is noted in women carrying a T allele at the rs1271572 locus of the oestrogen receptor 2 gene. 10 A study conducted in ovariectomised female rats has shown that 2 weeks of oestradiol supplementation reduced mortality in rats with TCMP-like cardiac dysfunction. 11 Another study has shown that oestradiol helps protect against the toxic effects of catecholamines on cardiac myocytes.…”

Section: The Role Of Oestrogen Deficiency In the Pathophysiology Of Tmentioning

confidence: 99%

Takotsubo Endocrinopathy

Kalra¹,

Lakhani²,

Chaudhary³

2020

European Endocrinology

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Section: The Role Of Oestrogen Deficiency In the Pathophysiology Of Tmentioning

confidence: 99%

Takotsubo Endocrinopathy

Kalra¹,

Lakhani²,

Chaudhary³

2020

European Endocrinology

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“…[585960] Eitel et al recently conducted the first genome-wide association study for TCM locating 68 candidate loci,[61] and some preliminary studies have also reported an association with estrogen receptor polymorphisms in both the ESR1 and ESR2 genes. [62] However, it is important to note that larger population studies are necessary to provide statistically significant genetic links for TCM.…”

Section: Etiopathogenesismentioning

confidence: 99%

Perioperative takotsubo cardiomyopathy: Implications for anesthesiologist

et al. 2019

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Takotsubo cardiomyopathy (TCM) is characterized by transient ventricular dysfunction in the absence of obstructive coronary artery disease that may be triggered by an acute medical illness or intense physical or emotional stress. TCM is often confused with acute myocardial infarction given the similar electrocardiographic changes, cardiac enzymes, hemodynamic perturbations, and myocardial wall motion abnormalities. In the perioperative setting, the clinical picture may be more confusing because of the effect of anesthesia as well as hemodynamic changes related to the surgery itself. However, awareness of various other diagnostic modalities may enable clinicians to distinguish between the two, more systematically and with greater certainty. Despite the large body of literature, there still seems to be an overall paucity in our understanding of the etiopathogenesis, clinical characteristics, natural history, and management of this syndrome, especially in the perioperative setting. This narrative review seeks to present and synthesize the most recent literature on TCM and to identify gaps in current knowledge which can become the basis for future research.

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“…42 In addition, a possible pathophysiological role of some polymorphisms of estrogen receptors a and b genes (Cys397Thr and Gly1839Thr, respectively) that reduce estrogen effects has been postulated. 43 However, recent data showed that TS occurred in postmenopausal women despite hormone replacement therapy 37 and that oophorectomized women did not evidence a worse clinical course, 44 suggesting that hypoestrogenemia itself cannot be the primary cause of TS development, even if it probably plays a protective role. Moreover, men show low estrogen levels throughout their life, so the sudden decrease of estrogen could be an explanation for the postmenopausal development of TS in women, but cannot explain why females are significantly more prone to TS than males.…”

Section: Ts and Gender: Does It Really Matter?mentioning

confidence: 99%

Influence of Genetics and Gender in Takotsubo Syndrome: Unexplored Areas of an Incompletely Understood Disease

LongobardoLuca

ZitoConcetta

Carerj

et al. 2017

Gender and the Genome

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Stress cardiomyopathy, also known as ''Takotsubo syndrome'' (TS), is a complex disease that typically affects postmenopausal women. The pathophysiology is still largely unknown, but evidence of a frequent association between TS and stressful events has evoked the hypothesis of a pathophysiologic role of sympathetic overdrive in the myocardial dysfunction. However, despite several studies, the role gender plays in TS onset remains unclear because stress cardiomyopathy also has been described in young women and in men. Moreover, although several cases of a familial cluster of TS have been reported, no responsible gene mutations or polymorphisms have been clearly identified so far, and neither the modality of transmission or the true impact of genetic background. In this review, we discuss the role of gender in the onset, course, and outcomes of TS and we report the available data about polymorphisms and gene mutations so far investigated, trying to critically analyze the evidence reported in the literature.

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Takotsubo syndrome and estrogen receptor genes

Abstract: The study reports preliminary findings suggesting a possible link between ESR polymorphisms and the occurrence of TS. Larger studies are needed to confirm our results.

Cited by 26 publications

References 34 publications

Takotsubo Endocrinopathy

Takotsubo Endocrinopathy

Perioperative takotsubo cardiomyopathy: Implications for anesthesiologist

Influence of Genetics and Gender in Takotsubo Syndrome: Unexplored Areas of an Incompletely Understood Disease

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