Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study

Zalewska-Adamiec, Małgorzata; Bachórzewska−Gajewska, Hanna; Tomaszuk‐Kazberuk, Anna; Nowak, Konrad; Drozdowski, P.; Bychowski, Jakub; Krynicki, Romuald; Musiał, Włodzimierz J.; Dobrzycki, Sławomir

doi:10.1007/s12471-016-0857-z

Cited by 40 publications

(36 citation statements)

References 21 publications

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“…However, a relatively high mortality of patients with TTS in comparison with those with myocardial infarction has been reported recently. 4,5,12 CKD is the recognized cardiovascular risk factor. It also adversely affects the prognosis of severe heart failure and ventricular arrhythmias, as well as with higher in -hospital mortality.…”

Section: Methodsmentioning

confidence: 99%

Takotsubo syndrome and chronic kidney disease - deadly duet in long-term follow-up

Zalewska-Adamiec¹,

Małyszko²,

Bachórzewska−Gajewska³

et al. 2018

Polish Archives of Internal Medicine

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Introduction The prognosis of takotsubo syndrome (TTS) was recognized as benign. However, patients with TTS and chronic kidney disease (CKD) more often experience severe complications in the acute phase of the disease, particularly sudden cardiac arrest. Objectives We aimed to assess the impact of CKD on early and long-term outcomes, including mortality, among 95 patients with TTS. Patients and methods All patients underwent coronary angiography. Clinical, biochemical, and other medical data were recorded. Estimated glomerular filtration rate was assessed using the CKD‑EPI formula. Results CKD was diagnosed in 32% of the patients. Contrast‑induced acute kidney injury (CI‑AKI) was not reported in any of the patients. Patients with CKD were older but had a lower prevalence of positive cardiovascular family history as well as higher creatine kinase activity and concentrations of inflammatory parameters. During hospitalization, sudden cardiac arrest was more common in CKD patients. In‑hospital, 1‑year, and long‑term mortality rates were the highest in CKD patients, reaching 33.3% in long‑term follow‑up. Predictors of death in a multivariate analysis were body mass index, ejection fraction, and serum creatinine concentrations. Conclusions CKD is a novel and still underestimated risk factor for TTS. It may trigger TTS but, more importantly, it adversely affects the outcomes. Thus, it is important to assess kidney function in all patients with TTS to evaluate the risk of morbidity and mortality in follow‑up, as well as to adjust drug doses and implement preventive measures to avoid CI‑AKI when coronary angiography or contrast‑enhanced computed tomography is performed.

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Section: Methodsmentioning

confidence: 99%

Takotsubo syndrome and chronic kidney disease - deadly duet in long-term follow-up

Zalewska-Adamiec¹,

Małyszko²,

Bachórzewska−Gajewska³

et al. 2018

Polish Archives of Internal Medicine

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“…For TTS patients with hypotension or shock, continuous monitoring of clinical parameters such as vital signs, mental status, urine output, and renal function should be done along with telemonitoring. Up to 5%-10% of patients with TTS can develop cardiogenic shock [5,27]. A variety of factors are associated with cardiogenic shock in TTS, including physical triggers, young age, and low LV ejection fraction.…”

Section: Tts With Complications -Hypotension and Cardiogenic Shockmentioning

confidence: 99%

Management of Takotsubo Syndrome: A Comprehensive Review

Sattar¹,

Siew²,

Connerney³

et al. 2020

Cureus

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“…66.4 ± 13.1 (89.8) 14.2 Citro et al [22] 190 66 ± 11.4 (92) 5.7 Falola et al [23] 1,724 65.3 (90.2) 1.6 Tornvall et al [24] 505 67 ± 10 (87.5) 6.5 Zalewska-Adamiec et al [25] 101…”

Section: [31]mentioning

confidence: 99%

Probable protective role of diabetes mellitus in takotsubo cardiomyopathy: a review

Gowdar¹,

Syal²,

Chhabra³

2017

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Takotsubo cardiomyopathy (TC) is a syndrome that predominantly affects postmenopausal women and is characterized by transient regional systolic dysfunction of the left ventricle which occurs in the absence of angiographic evidence of significant obstructive coronary artery disease. It is often but not always triggered by emotional or physical stressful stimuli. In most cases, the regional ventricular dysfunction extends beyond a single epicardial coronary artery territory. It typically involves the apex, with rare atypical presentations involving the base and right ventricle. Although the pathophysiological underpinnings of TC have not been completely elucidated, possible mechanisms include catecholamine overactivity, diffuse multivessel coronary spasm, microvascular dysfunction and estrogen deficiency. The prevalence of diabetes mellitus has been noted to be low in multiple studies of patients with TC. In this review, the authors discuss the association between diabetes mellitus and TC, with a special emphasis on the possible protective effect of diabetes mellitus in development of TC. Key words:Diabetes mellitus, stress cardiomyopathy, takotsubo cardiomyopathy ABSTRACTArticle history:

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Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study

Cited by 40 publications

References 21 publications

Takotsubo syndrome and chronic kidney disease - deadly duet in long-term follow-up

Takotsubo syndrome and chronic kidney disease - deadly duet in long-term follow-up

Management of Takotsubo Syndrome: A Comprehensive Review

Probable protective role of diabetes mellitus in takotsubo cardiomyopathy: a review

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