Takotsubo Cardiomyopathy in a Case of Intracerebral Hemorrhage: A Case Report

Nagpal, Raghav R; Dhabhar, Jeyhan; Ghanekar, Jaishree

doi:10.7759/cureus.5711

Cited by 4 publications

(2 citation statements)

References 10 publications

(10 reference statements)

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“…27 Noncardiac medical conditions, in particular, neurological, such as intracranial hemorrhage, pheochromocytoma, and epilepsy, or severe acute critical illnesses can induce takotsubo syndrome. [28][29][30] Cancer is increasingly recognized as a precipitant, and this may relate to the direct mental stress from receiving a diagnosis of malignancy or the combined mental and physical stress of cancer treatments. 31 Stresses from a range of physical illnesses or procedures are also recognized and include acute exacerbations of asthma or chronic obstructive pulmonary disease, endoscopic examinations, cardioversions, and many others.…”

Section: Clinical Featuresmentioning

confidence: 99%

Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications

et al. 2022

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Takotsubo syndrome is a condition characterized by acute transient left ventricular systolic dysfunction, which at presentation can be challenging to distinguish from acute myocardial infarction. Although previously thought to be a benign, self-limiting condition, recent studies have confirmed that patients with takotsubo syndrome have persistent subtle ongoing cardiac dysfunction, and many continue to have limiting symptoms despite restoration of left ventricular ejection fraction. Moreover, these patients have a substantial burden of morbidity and mortality, as well, with high rates of subsequent major adverse cardiovascular events that approach those of patients with acute coronary syndrome. The mechanisms behind this condition remain elusive. Despite substantial research, the medical community continues to have an incomplete understanding of its underlying pathogenesis and pathophysiology. Catecholamine-induced myocardial injury is the most established and well-known theory, but this does not explain all the clinical features and presentations of the condition, and numerous other pathways and abnormalities are emerging. Because of the poor understanding of its underlying pathophysiology, there is a lack of evidence-based interventions to treat the acute episode, to avoid recurrences, and to prevent major adverse cardiovascular events. This highlights the need for further research to gain a better understanding of the underlying pathophysiology to inform appropriate randomized controlled trials of interventions targeting the causative pathways. Only then can evidence-based management strategies be established to improve clinical outcomes of this potentially lethal condition.

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Section: Clinical Featuresmentioning

confidence: 99%

Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications

et al. 2022

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“…TCM is characterized by transient left ventricular dysfunction without significant coronary artery disease. It typically presents as acute chest pain, electrocardiographic changes resembling acute coronary syndrome, and reversible left ventricular wall motion abnormalities [ 3 - 4 ]. The incidence of TCM following ICH is relatively rare but well-documented in the medical literature.…”

Section: Discussionmentioning

confidence: 99%

Intracranial Hemorrhage Induced Takotsubo Cardiomyopathy: A Case Report

Mann¹,

Pokhriyal²,

Kusayev³

et al. 2023

Cureus

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Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy or "broken heart syndrome," is a reversible cardiac disorder characterized by left ventricular dysfunction without significant obstructive coronary artery disease. It is classically secondary to emotional stress in postmenopausal women but can also be secondary to physical stress. This report presents a unique case of takotsubo cardiomyopathy induced by intracranial hemorrhage in an 80-year-old female who presented with syncope.

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