Takotsubo Cardiomyopathy Following Liver Transplantation: A Report of 2 Cases

Shamaa, Omar; Jafri, Syed Mohammed; Shamaa, Mhd Tayseer; Brown, Kimberly; Venkat, Deepak

doi:10.1016/j.transproceed.2020.07.021

Cited by 5 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although physicians describe a benign and transient clinical course in 90% of cases, this syndrome is often associated with electrical instability, cardiogenic shock, ventricular arrhythmias, heart failure, and pulmonary edema, characterized by high morbidity and mortality. Several etiological theories have been proposed to explain the pathogenesis of Takotsubo syndrome; the excess of circulating catecholamines, microvascular dysfunction, and intense coronary spasms have been taken into consideration, but the exact pathogenetic mechanism has not yet been understood [ 46 , 47 , 84 , 85 , 86 , 87 , 88 ]. Excess catecholamines directly affect cardiomyocytes with myocardial stunning (stunning), coronary vasospasm, myocardial ischemia, microcirculatory dysfunction, and left ventricular dysfunction [ 46 , 85 , 88 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Comprehensive Review on Alcohol Abuse Disorder Fatality, from Alcohol Binges to Alcoholic Cardiomyopathy

Argo,

Pitingaro,

Puntarello

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Frequent and excessive consumption of alcohol, be it episodic or sustained misuse, ranks among the top causes of mortality globally. This comprehensive analysis seeks to elucidate how alcohol misuse precipitates death, with a particular focus on associated cardiac anomalies. Notably, the phenomenon of “Holiday Heart Syndrome”, linked to binge drinking, is recognized for inducing potentially fatal cardiac arrhythmias. Moreover, persistent alcohol consumption is implicated in the development of alcoholic cardiomyopathy, a condition that underlies heart failure and arrhythmic disturbances of the heart. Additionally, individuals undergoing withdrawal from alcohol frequently exhibit disruptions in normal heart rhythm, posing a risk of death. This review further delves into additional alcohol-related mortality factors, including the heightened likelihood of hypertension, cerebrovascular accidents (strokes), and the connection between excessive alcohol use and Takotsubo syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Clinically, TC manifests itself early, simulating myocardial infarction with chest pain, dyspnea, and syncope. Still, the absence of coronary pathology on angiographic examination helps to differentiate the two pathological entities [ 46 , 84 , 86 , 88 , 89 ].…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Review on Alcohol Abuse Disorder Fatality, from Alcohol Binges to Alcoholic Cardiomyopathy

Argo,

Pitingaro,

Puntarello

et al. 2024

Diagnostics

View full text Add to dashboard Cite

show abstract

“…TTS was first reported in OLT patients in 2007 21 . Since then, more than 300 post-OLT TTS cases have been reported (Table 1 ) 5 , 8 , 9 , 11 , 18 , 20 , 24 , 25 . Compared to non-OLT surgery, OLT patients appear to be at a higher risk for the development of TTS 5 , 9 , 25 , 26 .…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, it was reported that the index/in-hospital mortality among TTS following OLT reached as high as 7% 5 . Moreover, there were rare reports of a small number of TTS deaths following lung and OLT 19 , 20 . Furthermore, mortality during readmissions within the calendar year was higher in OLTs with TTS in comparison to non-TTS recipients in one study (5.4% vs. 1.7%, P = 0.02) 5 .…”

Section: Introductionmentioning

confidence: 99%

Takotsubo cardiomyopathy after solid organ transplantation: a scoping review

Rawashdeh,

Yaghmour,

Sulieman

et al. 2024

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy that causes temporary left ventricular wall motion abnormalities and abrupt reversible heart failure. The incidence of perioperative TTS is proportional to the severity of surgical trauma, the duration of the procedure, and the degree of apparent sympathetic activity. A growing number of articles have discussed TTS after solid organ transplant (SOT), which is one of the circumstances in which physical and emotional stress are at their highest levels. The majority of published cases involved patients who had received an orthotopic liver transplant (OLT). TTS occurred in 0.3-1.7% of liver transplant recipients, but a limited number of cases of TTS in patients who had received kidney, heart, or lung transplants have also been documented. In this study, we analyzed the TTS instances that developed after SOT, highlighting the symptoms and causes as well as the various treatment approaches that were applied. Most TTS cases following OLT and kidney transplant cases occurred in the first week of the surgery. However, the majority of cases occurred years after heart transplantation. Dizziness, dyspnea, and chest discomfort are the most typical symptoms. Patients may also experience syncope and generalized weakness. In spite of this, the symptoms differ depending on the transplanted organ. Dyspnea is a common symptom after lung transplants, whereas chest discomfort and dizziness are a common symptom after liver and kidney transplants. Yet, chest pain is not a typical symptom after a heart transplant.

show abstract

“…This apical ballooning cardiomyopathy has also been described in the post liver transplant setting. 50…”

Section: Introductionmentioning

confidence: 99%

Point-of-Care Echocardiography and Hemodynamic Monitoring in Cirrhosis and Acute-on-Chronic Liver Failure in the COVID-19 Era

Premkumar

Kajal

Kulkarni

et al. 2021

J Intensive Care Med

View full text Add to dashboard Cite

Point-of-Care (POC) transthoracic echocardiography (TTE) is transforming the management of patients with cirrhosis presenting with septic shock, acute kidney injury, hepatorenal syndrome and acute-on-chronic liver failure (ACLF) by correctly assessing the hemodynamic and volume status at the bedside using combined echocardiography and POC ultrasound (POCUS). When POC TTE is performed by the hepatologist or intensivist in the intensive care unit (ICU), and interpreted remotely by a cardiologist, it can rule out cardiovascular conditions that may be contributing to undifferentiated shock, such as diastolic dysfunction, myocardial infarction, myocarditis, regional wall motion abnormalities and pulmonary embolism. The COVID-19 pandemic has led to a delay in seeking medical treatment, reduced invasive interventions and deferment in referrals leading to “collateral damage” in critically ill patients with liver disease. Thus, the use of telemedicine in the ICU (Tele-ICU) has integrated cardiology, intensive care, and hepatology practices across the spectrum of ICU, operating room, and transplant healthcare. Telecardiology tools have improved bedside diagnosis when introduced as part of COVID-19 care by remote supervision and interpretation of POCUS and echocardiographic data. In this review, we present the contemporary approach of using POC echocardiography and offer a practical guide for primary care hepatologists and gastroenterologists for cardiac assessment in critically ill patients with cirrhosis and ACLF. Evidenced based use of Tele-ICU can prevent delay in cardiac diagnosis, optimize safe use of expert resources and ensure timely care in the setting of critically ill cirrhosis, ACLF and liver transplantation in the COVID-19 era.

show abstract

Takotsubo Cardiomyopathy Following Liver Transplantation: A Report of 2 Cases

Cited by 5 publications

References 16 publications

A Comprehensive Review on Alcohol Abuse Disorder Fatality, from Alcohol Binges to Alcoholic Cardiomyopathy

A Comprehensive Review on Alcohol Abuse Disorder Fatality, from Alcohol Binges to Alcoholic Cardiomyopathy

Takotsubo cardiomyopathy after solid organ transplantation: a scoping review

Point-of-Care Echocardiography and Hemodynamic Monitoring in Cirrhosis and Acute-on-Chronic Liver Failure in the COVID-19 Era

Contact Info

Product

Resources

About