Taking your breath away: metabolomics breathes life in to personalized medicine

Rattray, Nicholas A.; Hamrang, Zahra; Trivedi, Drupad K.; Goodacre, Royston; Fowler, Stephen J.

doi:10.1016/j.tibtech.2014.08.003

Cited by 144 publications

(102 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The major challenge limiting the application of breath analysis in the clinical domain is the lack of standardization in both breath collection [4, 5, 205] and analytical approaches [4, 205, 206], which contribute to the wide variations of reported analytical results [5, 99, 182, 207]. Additionally, insight into the metabolic aspects and background physiology of breath VOCs and their exact contributions both to healthy and diseased states is required to justify their clinical importance from a diagnostic point of view.…”

Section: Resultsmentioning

confidence: 99%

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

View full text Add to dashboard Cite

Analysis of volatile organic compounds (VOCs) emanating from human exhaled breath can provide deep insight into the status of various biochemical processes in the human body. VOCs can serve as potential biomarkers of physiological and pathophysiological conditions related to several diseases. Breath VOC analysis, a noninvasive and quick biomonitoring approach, also has potential for the early detection and progress monitoring of several diseases. This paper gives an overview of the major VOCs present in human exhaled breath, possible biochemical pathways of breath VOC generation, diagnostic importance of their analysis, and analytical techniques used in the breath test. Breath analysis relating to diabetes mellitus and its characteristic breath biomarkers is focused on. Finally, some challenges and limitations of the breath test are discussed.

show abstract

Section: Resultsmentioning

confidence: 99%

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

View full text Add to dashboard Cite

show abstract

“…Volatile organic compound (VOC) analysis has been researched extensively for disease diagnosis via detection of chemical markers 1, 2. It has been used to diagnose lung cancer and Alzheimer's disease, among many others 1.…”

mentioning

confidence: 99%

Classifying Degraded Modern Polymeric Museum Artefacts by Their Smell

et al. 2018

View full text Add to dashboard Cite

The use of VOC analysis to diagnose degradation in modern polymeric museum artefacts is reported. Volatile organic compound (VOC) analysis is a successful method for diagnosing medical conditions but to date has found little application in museums. Modern polymers are increasingly found in museum collections but pose serious conservation difficulties owing to unstable and widely varying formulations. Solid‐phase microextraction gas chromatography/mass spectrometry and linear discriminant analysis were used to classify samples according to the length of time they had been artificially degraded. Accuracies in classification of 50–83 % were obtained after validation with separate test sets. The method was applied to three artefacts from collections at Tate to detect evidence of degradation. This approach could be used for any material in heritage collections and more widely in the field of polymer degradation.

show abstract

“…Breath-based proteomics using the Belectronic nose^are constructed from highly sensitive biological olfactory components that are coupled to electronic transducers [71]. Moreover, EBC-based lung cancer diagnosis has recently become more relevant, especially since studies have reported that EBCs can also be used to detect DNA mutations and DNA methylation patterns in lung cancer patients [72].…”

Section: Breath Prints As Promising Source For Early Lung Cancer Diagmentioning

confidence: 99%

Epigenetics in lung cancer diagnosis and therapy

Mehta

Dobersch

Romero‐Olmedo

et al. 2015

Cancer Metastasis Rev

155

121

View full text Add to dashboard Cite

Lung cancer is the leading cause of cancer-related deaths worldwide. The initiation and progression of lung cancer is the result of the interaction between permanent genetic and dynamic epigenetic alterations. DNA methylation is the best studied epigenetic mark in human cancers. Altered DNA methylation in cancer was identified in 1983. Within 30 years of this discovery, DNA methylation inhibitors are used clinically to treat a variety of cancers, highlighting the importance of the epigenetic basis of cancer. In addition, histone modifications, nucleosome remodeling, and micro RNA (miRNA)-mediated gene regulation are also fundamental to tumor genesis. Distinct chromatin alterations occur in all stages of lung cancer, including initiation, growth, and metastasis. Therefore, stage-specific epigenetic changes can be used as powerful and reliable tools for early diagnosis of lung cancer and to monitor patient prognosis. Moreover, since epigenetic changes are dynamic and reversible, chromatin modifiers are promising targets for the development of more effective therapeutic strategies against cancer. This review summarizes the chromatin alterations in lung cancer, focusing on the diagnostic and therapeutic approaches targeting epigenetic modifications that could help to reduce the high case-fatality rate of this dreadful disease.

show abstract

Taking your breath away: metabolomics breathes life in to personalized medicine

Cited by 144 publications

References 78 publications

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Classifying Degraded Modern Polymeric Museum Artefacts by Their Smell

Epigenetics in lung cancer diagnosis and therapy

Contact Info

Product

Resources

About