Taking the pulse of aging: Mapping pulse pressure and elasticity in cerebral arteries with optical methods

Fabiani, Monica; Low, Kathy A.; Tan, Chin Hong; Zimmerman, Benjamin; Fletcher, Mark A.; Schneider-Garces, Nils; Maclin, Edward L.; Chiarelli, Antonio Maria; Sutton, Bradley P.; Gratton, Gabriele

doi:10.1111/psyp.12288

Cited by 66 publications

(162 citation statements)

References 140 publications

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“…Besides a reduction of cerebral blood flow, the ageing brain shows a decreased glucose and oxygen metabolism [15-17]. Similarly, it has been revealed that the retinal blood flow and metabolic demand decrease incrementally with age [18, 19].…”

Section: Discussionmentioning

confidence: 99%

The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke

et al. 2018

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Objectives: To measure the density of retinal vessels from digitized fundus photographs in patients with recent stroke and age-matched controls. To investigate whether the parameter retinal vascular density (RVD) served as a quantitative marker for cerebrovascular events. Methods: Digitized fundus photographs of n = 158 subjects with stroke or transient ischemic attack within 1 year at the time of examination and n = 1,250 age-matched controls without any remarkable medical history were examined. Sex, hypertension, and diabetes were considered to be cofactors. Measurement of RVD was performed with a computer-aided image-analyzing program by segmenting automatically all visible retinal vessels and measuring areas of vessels in distinct circles around the optic disk. Results: In controls RVD dwindles with increasing distance from the optic disk. RVD decreased significantly with age (p = 0.000). Stroke patients showed significantly lower values of RVD of –15% in comparison to age-matched controls. In old subjects, stroke in combination with hypertension is associated with a significant decreased RVD, and in middle-aged subjects diabetes and stroke are associated with a significant decreased RVD (p = 0.01). Conclusion: Age and stroke are significant risk factors for decreased RVD. Diabetes and arterial hypertension are additional significant risk factors in patients with stroke with respect to RVD.

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Section: Discussionmentioning

confidence: 99%

The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke

et al. 2018

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“…We applied this approach to study the correlates of arterial health in a large sample of normally aging healthy adults (age range ¼ 55 to 87), none of whom had any history of stroke or other major health problems. 64 In this sample, as predicted, pulse amplitude was positively correlated with age; the pulse relaxation function was instead positively correlated with measures of cardiorespiratory fitness (CRF) (see Fig. 4), but also with measures of cortical volume, white matter volume, and total cortical volume, indicating that more elastic arteries are associated with more preserved brain tissue in aging.…”

Section: Optical Pulse Signal: From Blood Vessels To Brainmentioning

confidence: 96%

“…65). However, we 64 have recently shown that the optical pulsation signal, or pulse-DOT (if measured using a sampling rate exceeding 20 Hz), in fact provides very useful data about the state of cerebral arteries. First, consistent with its arterial origin, the signal is oxygen-saturated >95%.…”

Section: Optical Pulse Signal: From Blood Vessels To Brainmentioning

confidence: 99%

From brain to blood vessels and back: a noninvasive optical imaging approach

2017

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Abstract. The seminal work of Grinvald et al. has paved the way for the use of intrinsic optical signals measured with reflection methods for the analysis of brain function. Although this work has focused on the absorption signal associated with deoxygenation, due to its detailed mapping ability and good signal-to-noise ratio, Grinvald's group has also described other intrinsic signals related to increased blood flow, scattering effects directly related to neural activation, and pulsation effects related to arterial function. These intrinsic optical signals can also be measured using noninvasive diffuse optical topographic and tomographic imaging (DOT) methods that can be applied to humans. Here we compare the reflection and DOT methods and the evidence for each type of intrinsic signal in these two domains, with particular attention to work that has been conducted in our laboratory. This work reveals the refined two-way relationship that exists between vascular and neural phenomena in the brain: arterial health is related to normal brain structure and function, both across individuals and across brain regions within an individual, and neural function influences blood flow to specific cortical regions. DOT methods can provide quantitative tools for investigating these relationships in normal human subjects.

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“…To overcome these limitations, we recently developed a new procedure to assess local cerebrovascular health using near-infrared (NIR) light (Fabiani et al, 2014; Tan et al, 2016; see also Tan et al, 2017). This technique involves injecting NIR light through the scalp and detecting the backscattered light at a certain distance from the light source.…”

Section: Introductionmentioning

confidence: 99%

“…In the brain, pulsation data can be easily obtained using the same procedures employed for functional near infrared spectroscopy (fNIRS; Hoshi & Tamura, 1993; Murkin & Arango, 2009; Villringer & Chance, 1997). The optical arterial pulse obtained in this fashion is a very large signal, easily identifiable in each individual subject and at each recording location without averaging, although even greater reliability can be achieved by averaging over a few minutes of recording (Fabiani et al, 2014; Tan et al, 2017). …”

Section: Introductionmentioning

confidence: 99%

Individual differences in regional cortical volumes across the life span are associated with regional optical measures of arterial elasticity

et al. 2017

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Aging is often accompanied by changes in brain anatomy and cerebrovascular health. However, the specific relationship between declines in regional cortical volumes and loss of cerebral arterial elasticity is less clear, as only global or very localized estimates of cerebrovascular health have been available. Here we employed a novel tomographic optical method (pulse-DOT) to derive local estimates of cerebral arterial elasticity and compared regional volumetric estimates (obtained with FreeSurfer) with optical arterial elasticity estimates from the same regions in 47 healthy adults (aged 18–75). Between-subject analyses revealed a global correlation between cortical volume and cortical arterial elasticity, which was a significant mediator of the association between age and cortical volume. Crucially, a novel within-subject analysis highlighted the spatial association between regional variability in cortical volumes and arterial elasticity in the same regions. This association strengthened with age. Gains in the predictability of cortical volumes from arterial elasticity data were obtained by sharpening the resolution up to individual cortical regions. These results indicate that some of the variance of sub-clinical age-related brain atrophy is associated with differences in the status of cerebral arteries, and can help to explain the unique patterns of brain atrophy found within each individual.

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Taking the pulse of aging: Mapping pulse pressure and elasticity in cerebral arteries with optical methods

Cited by 66 publications

References 140 publications

The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke

The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke

From brain to blood vessels and back: a noninvasive optical imaging approach

Individual differences in regional cortical volumes across the life span are associated with regional optical measures of arterial elasticity

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