Taking baby steps in molecular logic-based computation

Abstract

Constructs of fluorophores, receptors, spacers, 1O2 sensitizers, enzymes and oligonucleotides play their part in advancing the field of molecular logic-based computation.

Fluorescent logic systems for sensing and molecular computation: structure–activity relationships in edge-detection

“…Separate optimizations deserve to be done in future studies. The filter paper is then written with 15 254 nm light through a mask and read (after removing the mask) with 366 nm light excitation under our local conditions of temperature (ca. 20 C) and humidity (86 + 5% annual average).…”

“…These fluorescent switches form the vanguard of molecular 25 logic 7 -based computation which is now engaging hundreds of laboratories worldwide. The results summarized in books [8][9][10][11][12][13] are augmented by those available in recent reviews 14,15 and articles. [16][17][18][19][20][21][22][23][24][25][26][27] This field offers tiny logical information processors that operate in biorelevant spaces which are too small for 30 semiconductor devices to access conveniently.…”

“…We established the generality of a molecular design tool -the fluorescent PET (photoinduced electron transfer) sensor/switch 15 principle.…”

“…In order to mitigate such an effect to some extent, we lay down an arbitrary combination of differently-shaped objects. Such combinations also offer insight into potential interference between diffusing proton fronts where two objects are rather 15 close to each other in space. Gratifyingly, clear edge visualization occurs in all four cases (Figure 7).…”

“…Photographs of fluorescent images after multiple 15 exposure to writing light through the 'square' mask onto the substrate, containing the logical molecular solution including 4 prepared under optimum conditions, for varying cumulative times as noted in each photograph. 20 In spite of the failure reported in the previous paragraph, we were in possession of several edge detecting systems in bluegreen (with sensor 5), in green (with sensor 6) and in orange (with sensors 2 and 3).…”