Tailoring the internal structure of liquid crystalline nanoparticles responsive to fungal lipases: A potential platform for sustained drug release

Poletto, Fernanda; Lima, Fábio Bueno de; Lundberg, Dan; Nylander, Tommy; Loh, Watson

doi:10.1016/j.colsurfb.2016.08.003

Cited by 19 publications

(4 citation statements)

References 36 publications

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“…Self-assembled structures, including micelles, microemulsions, and inverse lyotropic nonlamellar liquid crystalline phases, have attracted increasing attention for their potential applications in drug delivery. − Formed by the self-assembly of biologically relevant amphiphilic lipids in excess water, these structures are in thermodynamic equilibrium with their surroundings and provide large lipid–water interfacial area for the solubilization of various bioactive molecules such as proteins and peptides or host them in their aqueous or oil domains. − Encapsulation of guest molecules into the nanoparticle dispersions of such nanostructures may offer many advantages, including protection from proteolysis and oxidation. ,− Additionally, such self-assembled nano-objects can be designed to be responsive to various stimuli, including temperature, , light, , presence of enzymes, , and pH. − These stimuli trigger structural changes in these colloidal nanoparticles and selectively modulate their activity or facilitate release of their active cargo. In this context, pH-sensitive lipid-based nanocarriers for AMPs are attractive for a wide range of pharmaceutical applications as they could provide self-regulated passive targeting to areas of specific pH in the body .…”

Section: Introductionmentioning

confidence: 99%

“…12−18 Encapsulation of guest molecules into the nanoparticle dispersions of such nanostructures may offer many advantages, including protection from proteolysis and oxidation. 11,19−23 Additionally, such self-assembled nanoobjects can be designed to be responsive to various stimuli, including temperature, 24,25 light, 26,27 presence of enzymes, 28,29 and pH. 30−33 These stimuli trigger structural changes in these colloidal nanoparticles and selectively modulate their activity or facilitate release of their active cargo.…”

Section: ■ Introductionmentioning

confidence: 99%

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From Structure to Function: pH-Switchable Antimicrobial Nano-Self-Assemblies

Gontsarik

Yaghmur

Ren

et al. 2018

ACS Appl. Mater. Interfaces

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Stimuli-responsive nanocarriers based on lipid self-assemblies have the potential to provide targeted delivery of antimicrobial peptides, limiting their side effects while protecting them from degradation in the biological environments. In the present study, we design and characterize a simple pH-responsive antimicrobial nanomaterial, formed through the self-assembly of oleic acid (OA) with the human cathelicidin LL-37 as a model for an amphiphilic antimicrobial peptide. Colloidal transformations from core–shell cylindrical micelles with a cross-sectional diameter of ∼5.5 nm and a length of ∼23 nm at pH 7.0 to aggregates of branched threadlike micelles at pH 5.0 were detected using synchrotron small-angle X-ray scattering, cryogenic transmission electron microscopy, and dynamic light scattering. Biological in vitro assays using an Escherichia coli bacteria strain showed high antimicrobial activity of the positively charged LL-37/OA aggregates at pH 5.0, which was not caused by the pH conditions themselves. Contrary to that, negligible antimicrobial activity was observed at pH 7.0 for the negatively charged cylindrical micelles. The nanocarrier’s ability to switch its biological activity “on” and “off” in response to changes in pH could be used to focus the antimicrobial peptides’ action to areas of specific pH in the body. The presented findings contribute to the fundamental understanding of lipid-peptide self-assembly and may open up a promising strategy for designing simple pH-responsive delivery systems for antimicrobial peptides.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

From Structure to Function: pH-Switchable Antimicrobial Nano-Self-Assemblies

Gontsarik

Yaghmur

Ren

et al. 2018

ACS Appl. Mater. Interfaces

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“…This triple-layered nanogel exhibited significant efficiency to treat extracellular and intracellular bacterial infections without potential adverse side effects. Another lipasetriggered formulation was reported by Loh and coworkers for potential treatment of fungal infection, where the lipase-sensitive polymer, polysorbate 80, was used to stabilize the phytantriol nanoparticles [65]. Lipase-mediated hydrolysis of polysorbate 80 to give polyethoxylatedsorbitan and oleic acid resulted in a structural transition of the nanoparticle and consecutively triggered specific drug release.…”

Section: Heparin Is a Common Anticoagulant Used In Precise Doses To C...mentioning

confidence: 99%

A review on smart bioresponsive drug delivery systems

Haleem

Khan

2019

JCP

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During the past several decades, many sensing mechanisms have emerged, which provide new control strategies for designing closed-loop drug delivery systems. For such systems, numerous bioresponsive materials are utilized to construct functional modules for the desired devices. The typical closed-loop drug delivery systems recently reported in this review. The stimuli-responsive polymers serve to provide a snapshot of the utility and complexity of polymers that can sense, process, and respond to stimuli in modulating the release of a drug. Stimuli-responsive drug delivery vehicles come in the form of polymersomes, liposomes, micelles and dendrimers. Therapeutics is designed to be controlled released from drug carriers through the structural transformations such as shrinking, swelling, and dissociation or unique responsive cleavage route.

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“…This triple-layered nanogel exhibited significant efficiency to treat extracellular and intracellular bacterial infections without potential side effects. Another lipase-triggered formulation was reported by Loh and coworkers for potential treatment of fungal infection, where the lipase-sensitive polymer, polysorbate 80, was used to stabilize the phytantriol nanoparticles (Poletto et al, 2016). Lipase-mediated hydrolysis of polysorbate 80 to give polyethoxylated sorbitan and oleic acid resulted in a structural transition of the nano-particle and consecutively triggered specific drug release.…”

Section: Enzyme-responsive Closed-loop Delivery Systemsmentioning

confidence: 99%

Advances in bioresponsive closed-loop drug delivery systems

Zhang

Yan

et al. 2018

International Journal of Pharmaceutics

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Controlled drug delivery systems are able to improve efficacy and safety of therapeutics by optimizing the duration and kinetics of release. Among them, closed-loop delivery strategies, also known as self-regulated administration, have proven to be a practical tool for homeostatic regulation, by tuning drug release as a function of biosignals relevant to physiological and pathological processes. A typical example is glucose-responsive insulin delivery system, which can mimic the pancreatic beta cells to release insulin with a proper dose at a proper time point by responding to plasma glucose levels. Similar self-regulated systems are also important in the treatment of other diseases including thrombosis and bacterial infection. In this review, we survey the recent advances in bioresponsive closed-loop drug delivery systems, including glucose-responsive, enzyme-activated, and other biosignal-mediated delivery systems. We also discuss the future opportunities and challenges in this field.

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Tailoring the internal structure of liquid crystalline nanoparticles responsive to fungal lipases: A potential platform for sustained drug release

Cited by 19 publications

References 36 publications

From Structure to Function: pH-Switchable Antimicrobial Nano-Self-Assemblies

From Structure to Function: pH-Switchable Antimicrobial Nano-Self-Assemblies

A review on smart bioresponsive drug delivery systems

Advances in bioresponsive closed-loop drug delivery systems

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