Tailoring the Heterostructure of Colloidal Quantum Dots for Ratiometric Optical Nanothermometry

Zhao, Hongbin; Vomiero, Alberto; Rosei, Federico

doi:10.1002/smll.202000804

Cited by 32 publications

(42 citation statements)

References 126 publications

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“…In addition, the temperature‐dependent changes in their fluorescence spectra make them highly promising non‐contact nano‐temperature probes. [ 14,15 ] Smith et al. [ 16 ] showed that QDs are stable within the pH range of 5–7 and can withstand other environmental changes, which is very critical for their application as temperature sensors for tumor cells.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the temperature-dependent changes in their fluorescence spectra make them highly promising non-contact nano-temperature probes. [14,15] Smith et al [16] showed that QDs are stable within the pH range of 5-7 and can withstand other environmental changes, which is very critical for their application as temperature sensors for tumor cells. Yang et al [17] used QDs to study the local thermogenic changes in NIH/3T3 mouse fibroblasts, and Wei et al [18] conjugated the thermo-sensitive dye Rhodamine B with biocompatible carbon dots via a covalent bond for measuring the temperature of living cells.…”

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confidence: 99%

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Targeted Nanoscale 3D Thermal Imaging of Tumor Cell Surface with Functionalized Quantum Dots

Yang

Chai

et al. 2021

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Measuring the changes in tumor cell surface temperature can provide insights into cellular metabolism and pathological features, which is significant for targeted chemotherapy and hyperthermic therapy. However, conventional micro–nano scale methods are invasive and can only measure the temperature of cells across a single plane, which excludes specific organelles. In this study, fluorescence quantum dots (QDs) are functionalized with the membrane transport protein transferrin (Tf) as a thermo‐sensor specific for tumor cell membrane. The covalent conjugation is optimized to maintain the relative fluorescence intensity of the Tf‐QDs to >90%. In addition, the Tf‐QDs undergo changes in the fluorescence spectra as a function of temperature, underscoring its thermo‐sensor function. Double helix point spread function imaging optical path is designed to locate the probe at nanoscale, and 3D thermal imaging technology is proposed to measure the local temperature distribution and direction of heat flux on the tumor cell surface. This novel targeted nanoscale 3D thermometry method can be a highly promising tool for measuring the local and global temperature distribution across intracellular organelles.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Targeted Nanoscale 3D Thermal Imaging of Tumor Cell Surface with Functionalized Quantum Dots

Yang

Chai

et al. 2021

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“…Temperature is an important physical parameter for scientific research and industrial production, and the accurate feedback of temperature change becomes more and more essential in modern practical applications [1–15] . It is usually hoped that the temperature detection system is high‐sensitive and high‐resolution, and the whole measurement process is non‐contact and non‐invasive [16–23] .…”

Section: Introductionmentioning

confidence: 99%

Rational Design of a Nd³⁺‐Mn⁴⁺ Co‐doped Luminescent Thermometer: Towards High‐Sensitivity Temperature Sensing

Wang

Zhang

et al. 2021

ChemPhotoChem

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High temperature sensitivity is an important development direction for luminescent thermometers, especially in the physiological temperature range. Herein, neodymium(III) and manganese(IV) ions were co‐doped into a yttrium gallium garnet host (YGG) and the relevant dopant concentrations were optimized in detail. The temperature‐dependent spectral survey indicates that when the temperature was above 240 K, the 2Eg→4A2g transition of Mn4+ and the 4F5/2→4I9/2 emission of Nd3+ show strong fluorescence quenching and gradual fluorescence enhancement, respectively. Such an apparent contrast mainly originates from the nonradiative cross‐relaxation between 2Eg (or 4T2g) and 4A2g states of Mn4+ and thermal coupling between the 4F5/2 and 4F3/2 levels of Nd3+, respectively. The obvious difference in fluorescence between the two luminescent ions leads to an excellent temperature sensing performance. The obtained relative sensitivity shows a maximum value at 280 K (7.90 % K−1) and maintains a magnitude above 5.00 % K−1 over the whole physiological temperature range. Moreover, the related temperature uncertainties are below 0.1 K from 298 K to 323 K, and the repeatability capability is larger than 98 %. The findings in this study offer a feasible approach to promote the sensing capability of temperature sensors by rationally designing co‐doping systems.

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“…Luminescence-based temperature sensing is outstanding due to its merits of being noninvasive and accurate [25][26][27] . Therefore, in terms of temperature sensing, luminescence studies of organic dyes 28 , lanthanide-based nanomaterials 29,30 , semiconductor nanocrystals [31][32][33][34] , and carbon dots 35,36 have attracted much attention.…”

Section: Introductionmentioning

confidence: 99%

Single Excited Dual Band Luminescent Hybrid Carbon Dots-terbium Chelate Nanothermometer

Zairov

Dovzhenko

Sarkanich

et al. 2021

Preprint

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The report introduces hybrid polyelectrolyte-stabilized colloids combining blue and green emitting building blocks, that are citrate carbon dots (CDs) and [TbL]+ chelate complexes with 1,3-diketonate derivatives of calix[4]arene. The joint incorporation of green and blue emitting blocks into the polysodium polystyrenesulfonate (PSS) aggregates is carried out through the solvent-exchange synthetic technique. The coordinative binding between Tb3+ centers and CD surface groups in initial DMF solutions both facilitates joint incorporation of [TbL]+ complexes and the CDs into the PSS-based nanobeads and affects fluorescence properties of [TbL]+ complexes and CDs, as well as their ability to temperature sensing. The variation of the synthetic conditions is represented herein as a tool for tuning the fluorescent response of the blue and green emitting blocks upon heating and cooling. The revealed regularities enable developing either dual band luminescent colloids for monitoring temperature changes within 25-50 C through double color emission, or to transform the colloids into ratiometric temperature sensors via simple concentration variation of [TbL]+ and CDs in initial DMF solution. Novel hybrid carbon dots-terbium chelate PSS-based nanoplatform opens an avenue for new generation of sensitive and customizable single excited dual band nanothermometers.

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Tailoring the Heterostructure of Colloidal Quantum Dots for Ratiometric Optical Nanothermometry

Abstract: nanothermometry using optical probes has attracted a great attention due to its outstanding properties, like high-sensitivity, low-cost, and noncontact detection for various systems.

Cited by 32 publications

References 126 publications

Targeted Nanoscale 3D Thermal Imaging of Tumor Cell Surface with Functionalized Quantum Dots

Targeted Nanoscale 3D Thermal Imaging of Tumor Cell Surface with Functionalized Quantum Dots

Rational Design of a Nd³⁺‐Mn⁴⁺ Co‐doped Luminescent Thermometer: Towards High‐Sensitivity Temperature Sensing

Single Excited Dual Band Luminescent Hybrid Carbon Dots-terbium Chelate Nanothermometer

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Tailoring the Heterostructure of Colloidal Quantum Dots for Ratiometric Optical Nanothermometry

Abstract: nanothermometry using optical probes has attracted a great attention due to its outstanding properties, like high-sensitivity, low-cost, and noncontact detection for various systems.

Cited by 32 publications

References 126 publications

Targeted Nanoscale 3D Thermal Imaging of Tumor Cell Surface with Functionalized Quantum Dots

Targeted Nanoscale 3D Thermal Imaging of Tumor Cell Surface with Functionalized Quantum Dots

Rational Design of a Nd3+‐Mn4+ Co‐doped Luminescent Thermometer: Towards High‐Sensitivity Temperature Sensing

Single Excited Dual Band Luminescent Hybrid Carbon Dots-terbium Chelate Nanothermometer

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Rational Design of a Nd³⁺‐Mn⁴⁺ Co‐doped Luminescent Thermometer: Towards High‐Sensitivity Temperature Sensing