Tailoring the delivery of therapeutic ions from bioactive scaffolds while inhibiting their apatite nucleation: a coaxial electrospinning strategy for soft tissue regeneration

Zhou, Pin; Wang, Jian; Maçon, Anthony L. B.; Obata, Akiko; Jones, Julian R.; Kasuga, Toshihiro

doi:10.1039/c6ra25645g

Cited by 9 publications

(4 citation statements)

References 50 publications

(73 reference statements)

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“…Despite the fact that homogeneous core-shell fibres were successfully obtained, the shell wall thickness of the resulting electrospun fibres did not display any detectable variation when the flow rate of the core solution was varied during coaxial electrospinning, as suggested elsewhere in the literature [86,87,88,89]. Due to the complex nature of the coaxial electrospinning, we hypothesise that varying the flow rate of the core solution did have detrimental impact on the co-spinnability of the selected solutions [87], thereby negatively impacting on the drug delivery and infection-triggered colour change capabilities of resulting fibres [90].…”

Section: Resultsmentioning

confidence: 81%

“…Due to inherent challenges associated with the formation of homogeneous core-shell electrospun fibres [ 85 ], electrospinning parameters were carefully adjusted in order to achieve continuous coating of the polymer-forming shell onto the fibre core: (i) the electric field strength of approximately 1.6 kV·cm −1 enabled minimised interfacial instability and the formation of a single Taylor cone including both the core- and the shell-forming solutions, rather than multiple jets and spinning of separate, non-coaxial fibres [ 86 ]. (ii) The selected flow rate of the core solution was lower than the shell solution in order to avoid intermingling of the core and shell solutions and facilitate the formation of an inner jet and bead-free uniform fibres [ 85 , 86 , 87 ]. (iii) The polymer concentration (10–12 wt.% PAA; 13 wt.% PMMA-co-MAA) and the viscosity of the core and shell solutions were also adjusted to avoid the intermingling between core and shell solutions [ 87 ].…”

Section: Resultsmentioning

confidence: 99%

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Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response

Bazbouz

Tronci

2019

Sensors

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The spread of antimicrobial resistance calls for chronic wound management devices that can engage with the wound exudate and signal infection by prompt visual effects. Here, the manufacture of a two-layer fibrous device with independently-controlled exudate management capability and visual infection responsivity was investigated by sequential free surface electrospinning of poly(methyl methacrylate-co-methacrylic acid) (PMMA-co-MAA) and poly(acrylic acid) (PAA). By selecting wound pH as infection indicator, PMMA-co-MAA fibres were encapsulated with halochromic bromothymol blue (BTB) to trigger colour changes at infection-induced alkaline pH. Likewise, the exudate management capability was integrated via the synthesis of a thermally-crosslinked network in electrospun PAA layer. PMMA-co-MAA fibres revealed high BTB loading efficiency (>80 wt.%) and demonstrated prompt colour change and selective dye release at infected-like media (pH > 7). The synthesis of the thermally-crosslinked PAA network successfully enabled high water uptake (WU = 1291 ± 48 − 2369 ± 34 wt.%) and swelling index (SI = 272 ± 4 − 285 ± 3 a.%), in contrast to electrospun PAA controls. This dual device functionality was lost when the same building blocks were configured in a single-layer mesh of core-shell fibres, whereby significant BTB release (~70 wt.%) was measured even at acidic pH. This study therefore demonstrates how the fibrous configuration can be conveniently manipulated to trigger structure-induced functionalities critical to chronic wound management and monitoring.

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Section: Resultsmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response

Bazbouz

Tronci

2019

Sensors

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“…When the particles dissolved, pores were left in the matrix and continuous pores, if any, transformed into channels. In our previous work [29], when PDLLG75 was coated on a material with Ca 2+ and silicate ion release capability, the resulting material's release kinetics followed the Weibull model, showing a purely diffusive release after the hydration of the PDLLG75 layer. In this work, because of the water uptake ability of PDLLGs, the MgSiV particles embedded tightly in the polymer matrix dissolve and ions diffuse through both the channel and the PDLLG matrix.…”

Section: Results and Discussion 31 Surface Morphologymentioning

confidence: 99%

Dissolution behavior of Mg/Si-doped vaterite particles in biodegradable polymer composites

Zhou¹,

Kasuga²

2018

Express Polym. Lett.

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Abstract. Tuning the ion release ability of bioactive materials is one of the key factors for bone repair and regeneration. Calcium (Ca 2+ ), magnesium (Mg 2+ ), and silicate ions were reported to enhance the activity of bone-forming cells. In this work, the dissolution behavior of magnesium-and silicate-doped calcium carbonate (vaterite), denoted as MgSiV, embedded in three kinds of biodegradable polymers in Tris buffer solutions (TBS) were examined to find an effective ion releasing system. Poly(L-lactic acid) (PLLA) and poly(D,L-lactide-co-glycolide) (PDLLG, lactide:glycolide = 75:25 or 50:50; denoted as PDLLG75 and PDLLG50, respectively) were chosen as the matrix polymers. The Mg 2+ and silicate ions were released rapidly within 3 d of soaking. Continuous release of Ca 2+ ions from the composites induced the formation of aragonite on the film surfaces in the presence of Mg 2+ ions. The amount of ions released from the MgSiV-PLLA composite was lesser than those released from the PDLLG-based composites. The fast degradation of PDLLG50 induced a decrease in the pH of TBS. The MgSiV-PDLLG75 composite exhibited a rapid release of Mg 2+ ions, a continuous release of Ca 2+ ions, and a controlled release of silicate ions with no reduction in the pH of TBS. Such release phenomena are caused by the formation of pathways for ion release, originating from the water uptake ability of PDLLG75.

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“…The hybrid nanofibers were fabricated with a modified air-blowing spinning technique, as described previously 19 . A professional fixed airbrush cup (Model BC 61 - 7cc Reservoir) was used to produce fibers layer-by-layer with a 0.3-mm standard nozzle, obtaining a non-woven fiber mat system 14 .…”

Section: Methodsmentioning

confidence: 99%

Evaluation of contact angle and mechanical properties of resin monomers filled with graphene oxide nanofibers

Velo,

Nascimento,

Obeid

et al. 2023

Braz. Dent. J.

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This in vitro study synthesized hybrid nanofibers embedded in graphene oxide (GO) and incorporated them into experimental resin composite monomers to evaluate their physical-mechanical properties. Inorganic-organic hybrid nanofibers were produced with precursor solutions of 1% wt. GO-filled Poly (d,l-lactide, PLA) fibers and scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) characterized the morphology and chemical composition of the spun fibers. Resin composite monomers were developed and a total of 5% nanofibers were incorporated into the experimental materials. Three groups were developed: G1 (control resin monomers), G2 (resin monomers/PLA nanofibers), and G3 (resin monomers/inorganic-organic hybrid nanofibers). Contact angle (n=3), flexural strength (n=22), elastic modulus (n=22), and Knoop hardness (n=6) were evaluated. The mean of the three indentations was obtained for each sample. The normality of data was assessed by QQ Plot with simulated envelopes and analyzed by Welch's method (p<0.05). Overall, SEM images showed the regular shape of nanofibers but were non-aligned. Compositional analysis from EDS (n=6) revealed the presence of carbon and oxygen (present in GO composition) and Si from the functionalization process. The results of contact angle (°) and hardness (Kg/mm2) for each group were as follow, respectively: G1 (59.65±2.90; 37.48±1.86a), G2 (67.99±3.93; 50.56±1.03b) and G3 (62.52±7.40; 67.83±1.01c). The group G3 showed the highest Knoop hardness values (67.83 kg/mm2), and the flexural strength of all groups was adversely affected. The experimental resin composite composed of hybrid nanofibers with GO presented increased hardness values and hydrophilic behavior.

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Tailoring the delivery of therapeutic ions from bioactive scaffolds while inhibiting their apatite nucleation: a coaxial electrospinning strategy for soft tissue regeneration

Cited by 9 publications

References 50 publications

Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response

Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response

Dissolution behavior of Mg/Si-doped vaterite particles in biodegradable polymer composites

Evaluation of contact angle and mechanical properties of resin monomers filled with graphene oxide nanofibers

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