Tailoring the cap’s morphology of electrodeposited gold micro-mushrooms

Cerquido, Mónica; Proença, Mariana P.; Dias, Catarina; Leitao, Diana C.; Freitas, P. P.; Freitas, P. P.; Aguiar, Paulo; Ventura, J.

doi:10.1016/j.apsusc.2018.03.158

Cited by 6 publications

(28 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[ 23,47,58 ] Thus, this study proved the benefit of using a deposition potential of −1.0 V, as widely implemented in the production of GMμEs. [ 31,32,35,43,47,51,59 ] Interestingly, a higher cathodic potential may be used for the fabrication of hollow GMμEs, as noted by Weidlich et al., [ 46 ] that used a two‐step electrodeposition (with a first short −1.35 V pulse for 5 s, followed by a second step at −1.1 V) to maintain the structural stability of their hollow mushroom microelectrodes.…”

Section: Gold‐mushroom Microelectrodesmentioning

confidence: 71%

“…[ 48 ] Such linear proportionality is confirmed in Figure a, where Cerquido et al. [ 47 ] tested different electrodeposition times at three distinct temperatures for holes of ≈2 µm in diameter. A similar study was performed by Decker et al.…”

Section: Gold‐mushroom Microelectrodesmentioning

confidence: 74%

“…[ 53 ] This effect was confirmed, by performing Au electrodeposition in micro‐holes at different bath temperatures and for different deposition times ( Figure ). [ 47 ]…”

Section: Gold‐mushroom Microelectrodesmentioning

confidence: 99%

“…The influence of these parameters has been studied extensively through simulations and laboratory experiments. [ 15,30,47,50 ]…”

Section: Impact Of Gmμes On Signal Acquisition and The Coupling Coeff...mentioning

confidence: 99%

See 3 more Smart Citations

Gold‐Mushroom Microelectrode Arrays and the Quest for Intracellular‐Like Recordings: Perspectives and Outlooks

Teixeira

Dias

Aguiar

et al. 2020

Adv Materials Technologies

View full text Add to dashboard Cite

The ongoing search to decode the brain communication system has propelled major advancements in bioelectronics research. From these, planar microelectrode arrays (MEAs) offer the possibility to record neuronal signals for extremely long periods of time and to probe fundamental principles of learning and adaptation. Unfortunately, MEAs have low neuronal coupling and are thus insensitive to sub‐threshold neuronal signals such as post‐synaptic responses. To surpass this major limitation, a novel category based on 3D high aspect ratio microstructures has emerged. In particular, gold‐mushroom microelectrode arrays (GMμEAs) have appeared as a solution. Their unique morphology, promoting cell engulfment without penetrating the neuron, prevents the occurrence of cell repairing mechanisms common in other microelectrodes. This new class of recording and/or stimulating devices have opened the door to the vast communication system of neuronal cells by enhancing the cell–microelectrode interface. This review compiles the fundamentals of these promising devices including their fabrication, work principles and focusing on how the different morphological parameters affect the recording performance. Although limitations exist, there is a growing interest to explore the new solutions that GMμEAs still offer, both as an electrophysiological tool (e.g., cell guidance) or in applications such as plasmonics.

show abstract

Section: Gold‐mushroom Microelectrodesmentioning

confidence: 71%

Section: Gold‐mushroom Microelectrodesmentioning

confidence: 74%

“…[ 53 ] This effect was confirmed, by performing Au electrodeposition in micro‐holes at different bath temperatures and for different deposition times ( Figure ). [ 47 ]…”

Section: Gold‐mushroom Microelectrodesmentioning

confidence: 99%

“…The influence of these parameters has been studied extensively through simulations and laboratory experiments. [ 15,30,47,50 ]…”

Section: Impact Of Gmμes On Signal Acquisition and The Coupling Coeff...mentioning

confidence: 99%

See 2 more Smart Citations

Gold‐Mushroom Microelectrode Arrays and the Quest for Intracellular‐Like Recordings: Perspectives and Outlooks

Teixeira

Dias

Aguiar

et al. 2020

Adv Materials Technologies

View full text Add to dashboard Cite

show abstract

“…The widespread use of platinum microelectrodes has been limited due to relatively high-impedance, low charge injection capacity, and possible cytotoxicity caused by dissolution of free ions during stimulation [9][10][11]. Moreover, the high-impedance of candidate materials such as platinum or gold, requires surface modification such as platinization [12], nano-structuring [13][14][15][16][17], or coating with conductive polymers to increase the surface area and improve neural recording and stimulation [18,19].. Metal oxides such as iridium oxide (IrOx) are often used as electrode coatings and have been widely used in neuroprosthetics due to their high charge injection capacity and low impedance compared to other electrode materials. IrOx has been prepared via activation of iridium metal in electrolyte solutions to form activated iridium oxide films (AIROF) or by reactive sputtering to form sputtered iridium oxide films (SIROF) [20].…”

Section: Introductionmentioning

confidence: 99%

Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation

et al. 2020

View full text Add to dashboard Cite

We have characterized the in vitro and in vivo extracellular neural recording and stimulation properties of ruthenium oxide (RuOx) based microelectrodes. Cytotoxicity and functional neurotoxicity assays were carried out to confirm the in vitro biocompatibility of RuOx. Material extract assays, in accordance to ISO protocol "10993-5: Biological evaluation of medical devices", revealed no significant effect on neuronal cell viability or the functional activity of cortical networks. In vitro microelectrode arrays (MEAs), with indium tin oxide (ITO) sites modified with sputtered iridium oxide (IrOx) and RuOx in a single array, were developed for a direct comparison of electrochemical and recording performance of RuOx to ITO and IrOx deposited microelectrode sites. The impedance of the RuOx-coated electrodes measured by electrochemical impedance spectroscopy was notably lower than that of ITO electrodes, resulting in robust extracellular recordings from cortical networks in vitro. We found comparable signal-to-noise ratios (SNRs) for RuOx and IrOx, both significantly higher than the SNR for ITO. RuOx-based MEAs were also fabricated and implanted in the rat motor cortex to demonstrate manufacturability of the RuOx processing and acute recording capabilities in vivo. We observed single-unit extracellular action potentials with a SNR >22, representing a first step for neurophysiological recordings in vivo with RuOx based microelectrodes.

show abstract

Vertical nanostructures for probing live cells

Zhang

Tsai

et al. 2021

Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms

View full text Add to dashboard Cite

Tailoring the cap’s morphology of electrodeposited gold micro-mushrooms

Cited by 6 publications

References 41 publications

Gold‐Mushroom Microelectrode Arrays and the Quest for Intracellular‐Like Recordings: Perspectives and Outlooks

Gold‐Mushroom Microelectrode Arrays and the Quest for Intracellular‐Like Recordings: Perspectives and Outlooks

Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation

Vertical nanostructures for probing live cells

Contact Info

Product

Resources

About