Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channels

Hassanin, Hany; Finet, Laurane; Cox, Sophie C.; Jamshidi, Parastoo; Grover, Liam M.; Shepherd, Duncan E.T.; Addison, Owen; Attallah, Moataz M.

doi:10.1016/j.addma.2018.01.005

Cited by 44 publications

(34 citation statements)

References 42 publications

(45 reference statements)

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“…As shown in Fig.4a-d, increasing the E v from 67 J/mm 3 to 178 J/mm 3 resulted in higher levels of densification, causing the pores to be blocked, and resulting in a more dense structure. This is attributed to the increase in strut size, ultimately reducing the pore size, due to the larger melt pool width at higher E v conditions [30]. Besides, as revealed in Fig.…”

Section: Surface/pore Morphologymentioning

confidence: 73%

Laser Powder Bed Fusion of Ti-rich TiNi lattice structures: Process optimisation, geometrical integrity, and phase transformations

Tan

Essa

et al. 2019

International Journal of Machine Tools and Manufacture

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108

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Section: Surface/pore Morphologymentioning

confidence: 73%

Laser Powder Bed Fusion of Ti-rich TiNi lattice structures: Process optimisation, geometrical integrity, and phase transformations

Tan

Essa

et al. 2019

International Journal of Machine Tools and Manufacture

Self Cite

108

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“…Additive manufacturing or 3D printing is a technology to create objects layer by layer using a 3D printer according to a digital model. The technology enabling the processing of metals [ 30 , 31 , 32 , 33 ], ceramics [ 34 ], polymers [ 35 ], and composites [ 36 ] has been widely employed in many industries, such as biomedical [ 37 ], defense [ 17 ], aerospace [ 38 , 39 ], and energy [ 40 ]. The ability of AM to process a wide range of materials into objects with intricate geometries such as auxetic and cellular structures and to obtain desired mechanical properties has led to the many advancements of this technology.…”

Section: Introductionmentioning

confidence: 99%

4D Printing of NiTi Auxetic Structure with Improved Ballistic Performance

et al. 2020

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Auxetic structures have attracted attention in energy absorption applications owing to their improved shear modulus and enhanced resistance to indentation. On the other hand, four-dimensional (4D) printing is an emerging technology that is capable of 3D printing smart materials with additional functionality. This paper introduces the development of a NiTi negative-Poisson’s-ratio structure with superelasticity/shape memory capabilities for improved ballistic applications. An analytical model was initially used to optimize the geometrical parameters of a re-entrant auxetic structure. It was found that the re-entrant auxetic structure with a cell angle of −30° produced the highest Poisson’s ratio of −2.089. The 4D printing process using a powder bed fusion system was used to fabricate the optimized NiTi auxetic structure. The measured negative Poisson’s ratio of the fabricated auxetic structure was found in agreement with both the analytical model and the finite element simulation. A finite element model was developed to simulate the dynamic response of the optimized auxetic NiTi structure subjected to different projectile speeds. Three stages of the impact process describing the penetration of the top plate, auxetic structure, and bottom plate have been identified. The results show that the optimized auxetic structures affect the dynamic response of the projectile by getting denser toward the impact location. This helped to improve the energy absorbed per unit mass of the NiTi auxetic structure to about two times higher than that of the solid NiTi plate and five times higher than that of the solid conventional steel plate.

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“…a hollow implant. In this way, the release characteristics of the therapeutic agents can be tailored both by altering the characteristics of the delivery vehicle, and by modification of the implant pore structures through which elution is achieved [124,125]. Addition of permeable membranes on the outside of a porous implant could further optimise elution, and enable loading of the eluting agent prior to implant insertion [126].…”

Section: Functional Implantsmentioning

confidence: 99%

Clinical, industrial, and research perspectives on powder bed fusion additively manufactured metal implants

Lowther

Louth

Davey

et al. 2019

Additive Manufacturing

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A B S T R A C TFor over ten years, metallic skeletal endoprostheses have been produced in select cases by additive manufacturing (AM) and increasing awareness is driving demand for wider access to the technology. This review brings together key stakeholder perspectives on the translation of AM research; clinical application, ongoing research in the field of powder bed fusion, and the current regulatory framework. The current clinical use of AM is assessed, both on a mass-manufactured scale and bespoke application for patient specific implants. To illuminate the benefits to clinicians, a case study on the provision of custom cranioplasty is provided based on prosthetist testimony. Current progress in research is discussed, with immediate gains to be made through increased design freedom described at both meso-and macro-scale, as well as long-term goals in alloy development including bioactive materials. In all cases, focus is given to specific clinical challenges such as stress shielding and osseointegration. Outstanding challenges in industrialisation of AM are openly raised, with possible solutions assessed. Finally, overarching context is given with a review of the regulatory framework involved in translating AM implants, with particular emphasis placed on customisation within an orthopaedic remit. A viable future for AM of metal implants is presented, and it is suggested that continuing collaboration between all stakeholders will enable acceleration of the translation process. fection or surgical complications [11][12][13].Currently, the majority of skeletal endoprostheses are produced from titanium (Ti) or cobalt chromium (CoCr) based alloys, which meet the criteria of durability, strength, corrosion resistance and a low immune response [14,15]. These characteristics however come at the cost of the high stiffness of these alloys in comparison to bone. Mismatch between the mechanical properties of bone and orthopaedic materials

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Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channels

Cited by 44 publications

References 42 publications

Laser Powder Bed Fusion of Ti-rich TiNi lattice structures: Process optimisation, geometrical integrity, and phase transformations

Laser Powder Bed Fusion of Ti-rich TiNi lattice structures: Process optimisation, geometrical integrity, and phase transformations

4D Printing of NiTi Auxetic Structure with Improved Ballistic Performance

Clinical, industrial, and research perspectives on powder bed fusion additively manufactured metal implants

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