Tailoring of berberine loaded transniosomes for the management of skin cancer in mice

Gupta, Dipak Kumar; Aqil, Mohd.; Ahad, Abdul; Imam, Syed Sarim; Waheed, Ayesha; Qadir, Abdul; Iqubal, Mohammad Kashif; Sultana, Yasmin

doi:10.1016/j.jddst.2020.102051

Cited by 25 publications

(24 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Box-Behnken designs are used to generate higher order response surfaces using fewer required runs than a normal factorial technique. The BBD offers 17 permutations for use in creating NLCs to develop a proper understanding within the design space ( Gupta et al, 2020 , Sartaj and Annu, 2022 ).The center points are important for Box-Behnken Design as this design is devoid of corner points and the center points improve the predictability. The link between the independent and dependent variables was further evaluated by generating polynomial equations and various response graphs using the chosen model ( Alam et al, 2023 , Rizwanullah et al, 2021 ).The design's validation involved the random selection of three compositions recommended by the software, including the optimized version.…”

Section: Methodsmentioning

confidence: 99%

Optimized Ribociclib nanostructured lipid carrier for the amelioration of skin cancer: Inferences from ex-vivo skin permeation and dermatokinetic studies

Aldawsari,

Kamal,

Balaha

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Optimized Ribociclib nanostructured lipid carrier for the amelioration of skin cancer: Inferences from ex-vivo skin permeation and dermatokinetic studies

Aldawsari,

Kamal,

Balaha

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

“…To determine the optimal composition, these independent variables were measured at lowest (−), medium (0), and highest (+) amounts. To evaluate the influence of independent variables, the design represented 17 formulation runs (different compositions) with three centers (Table 2). Using polynomial equations and response surface plots, the influence of independent factors was determined.…”

Section: Methodsmentioning

confidence: 99%

“…Rhodamine B was excited by a 488 nm Argon laser beam, after which fluorescence emission was measured at 532 nm. By using CLSM, the researchers were able to compare the AgN‐CA nanoparticle's penetration depth with that of the control group 17 …”

Section: Methodsmentioning

confidence: 99%

Microwave‐assisted and chemically tailored chlorogenic acid‐functionalized silver nanoparticles of Citrus sinensis in gel matrix aiding QbD design for the treatment of acne

Alam

Foudah

Alqarni

et al. 2023

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background Numerous studies have shown that various products of Citrus sinensis, for example, crude extracts, essential oil, and purified components, possess anti‐acne properties. However, the development of chlorogenic acid‐functionalized silver nanoparticles of C. sinensis in gel matrix aiding QbD design has not been evaluated for acne treatment. Aim In this study, we have developed chlorogenic acid‐functionalized silver nanoparticles of C. sinensis in a gel matrix employing a QbD approach for acne treatment. Material and Method Citrus sinensis extract‐loaded silver nanoparticles were functionalized with chlorogenic acid, which acted as a bio‐reducing agent and further improved anti‐acne properties. The developed formulation was optimized via Box‐Behnken Design. The formulation morphology was evaluated by transmission electron microscopy (TEM). The release profile of C. sinensis extract formulation was assessed by an in vitro release study and confocal laser scanning microscopy (CLSM). Moreover, the characterization study of the gel was performed that included an evaluation of the extrudability and spreadability of the developed gel. Furthermore, the anti‐oxidant efficacy of AgN‐CA formulation was validated using the DPPH test. Results The results showed a particle size of 71.78 nm, a polydispersity index of 0.297, a zeta potential of −36.12 mV, and an entrapment efficiency of 79.42% ± 6.79%. The results also indicated a uniform particle size. The release profile of C. sinensis extract revealed that 73.95% of the drug was released, whereas CLSM pictures of mice skin evidently demonstrated that the rhodamine B‐treated AgN‐CA gel penetrated much more extensively in comparison to the control. Furthermore, the anti‐oxidant efficacy of AgN‐CA formulation was validated using the DPPH test. Moreover, the characterization study of the developed gel, including its extrudability and spreadability, was found to be 16.02 ± 3.21 g and 30.73 ± 5.94 g cm/s, respectively. Also, texture analysis findings revealed that AgN‐CA gel had firmness, consistency, cohesiveness, and viscosity index of 159.69 g, 634.95 g s, −116.33 g, and −501.80 g s, respectively, indicating that the AgN‐CA gel was stable. Conclusion The current study showed that AgN‐CA is an effective drug carrier system for the topical administration of C. sinensis extract for the treatment of acne.

show abstract

“…Honokiol/ transferosomes/ melanoma [ 340 ] , melittin/ lipoosmes/ melanoma [ 341 ] , berberine/ transniosomes/ skin cancer [ 342 ] , protein kinase C inhibitor, BRD4 PROTAC/ liposomes/ melanoma [ 343 ] , hispolon, doxorubicin/ liposomes/ melanoma [ 344 ] , phenylethylresorcinol/ liposomes, transferosomes, invasomes/ melanoma [ 345 ] , brucine/ ethosomes/ melanoma [ 346 ] , berberine chloride, evodiamine/ ethosomes/ melanoma [ 347 ] , 5-fluorouracil/ ethosomes/ melanoma [ 348 ] , doxorubicin, Au, TRP-2, polyinosinic:polycytidylic acid/ liposomes, chitosan, poly(lactide-co-glycolic acid)/ melanoma [ 349 ] are few more investigations of nanovesicles that endowed excellent anti-skin cancer efficacy.…”

Section: Lipid-based Nanoparticles For Skin Cancer Therapymentioning

confidence: 99%

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

et al. 2023

View full text Add to dashboard Cite

Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously rising environmental changes, industrialization, and genetic modification have further exacerbated skin cancer statistics. Current treatment modalities such as surgery, radiotherapy, conventional chemotherapy, targeted therapy, and immunotherapy are facing several issues related to cost, toxicity, and bioavailability thereby leading to declined anti-skin cancer therapeutic efficacy and poor patient compliance. In the context of overcoming this limitation, several nanotechnological advancements have been witnessed so far. Among various nanomaterials, nanoparticles have endowed exorbitant advantages by acting as both therapeutic agents and drug carriers for the remarkable treatment of skin cancer. The small size and large surface area to volume ratio of nanoparticles escalate the skin tumor uptake through their leaky vasculature resulting in enhanced therapeutic efficacy. In this context, the present review provides up to date information about different types and pathology of skin cancer, followed by their current treatment modalities and associated drawbacks. Furthermore, it meticulously discusses the role of numerous inorganic, polymer, and lipid-based nanoparticles in skin cancer therapy with subsequent descriptions of their patents and clinical trials. Graphical Abstract

show abstract

Tailoring of berberine loaded transniosomes for the management of skin cancer in mice

Cited by 25 publications

References 43 publications

Optimized Ribociclib nanostructured lipid carrier for the amelioration of skin cancer: Inferences from ex-vivo skin permeation and dermatokinetic studies

Optimized Ribociclib nanostructured lipid carrier for the amelioration of skin cancer: Inferences from ex-vivo skin permeation and dermatokinetic studies

Microwave‐assisted and chemically tailored chlorogenic acid‐functionalized silver nanoparticles of Citrus sinensis in gel matrix aiding QbD design for the treatment of acne

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

Contact Info

Product

Resources

About