Tailoring nanoparticles design for enhanced heating efficiency and improved magneto-chemo therapy for glioblastoma

Gupta, Ruby; Kaur, Tashmeen; Chauhan, Anjali; Kumar, Ravi; Kuanr, Bijoy K.; Sharma, Deepika

doi:10.1016/j.bioadv.2022.213021

Cited by 10 publications

(11 citation statements)

References 71 publications

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“…This significant increase in temperature can be attributed to the higher anisotropy energy exhibited by the cube-like nanoparticles. 17 Anisotropic iron oxide-based nanomaterials, including nanocubes, core–shell nanostructures, and multicore MNPs, have been previously recognized for their exceptional magnetic heating capabilities, displaying specific loss powers significantly higher than those observed with conventional iron oxide nanoparticles utilized for MHCT.…”

Section: Resultsmentioning

confidence: 99%

“…15 On the other hand, magnetic hyperthermia-based cancer therapy (MHCT) relies on the ability of magnetic nanoparticles (MNPs) to induce heat in response to an external alternating current magnetic field (AMF). 16,17 The oscillation of magnetic moments in MNPs generates a localized temperature rise, selectively killing heat-sensitive tumor cells with minimal adverse effects on healthy cells. 18,19 However, the use of MNPs in cancer therapeutics presents various challenges.…”

Section: Deepika Sharmamentioning

confidence: 99%

“…24 Recent studies have focussed on strategies to enhance the hyperthermic performance of MNPs by regulating their physical properties such as tuning the size, magnetization and shape of MNPs. 17,25,26 Synthesizing nanoparticles with various structural morphologies allows control over shape anisotropy, improving hysteresis losses and the specific absorption rate (SAR) for hyperthermia. For example, magnetic nanorods have shown higher hyperthermic efficacy due to their high aspect ratio.…”

Section: Deepika Sharmamentioning

confidence: 99%

“…45 In a recent study conducted by our group, cubic MNPs showed the best heating performance due to their high SAR, making them promising for magneto-chemotherapy on glioma cells. 17 Additionally, Espinosa et al employed simultaneous stimulation of iron oxide nanocubes with an AMF and NIR laser irradiation, resulting in an outstanding heating efficiency at clinically acceptable irradiation doses and low iron concentrations. 46 In the present study, Si-NCs exhibited higher heating efficiency compared to Si-NSs, as indicated by the higher SAR values (Fig.…”

Section: Calorimetric Hyperthermia Profile Of Mnpsmentioning

confidence: 99%

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Self-propelling bacteria-based magnetic nanoparticles (BacMags) for targeted magnetic hyperthermia therapy against hypoxic tumors

Kaur,

Sharma

2024

Nanoscale

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Section: Resultsmentioning

confidence: 99%

Section: Deepika Sharmamentioning

confidence: 99%

Section: Deepika Sharmamentioning

confidence: 99%

Section: Calorimetric Hyperthermia Profile Of Mnpsmentioning

confidence: 99%

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Self-propelling bacteria-based magnetic nanoparticles (BacMags) for targeted magnetic hyperthermia therapy against hypoxic tumors

Kaur,

Sharma

2024

Nanoscale

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“…The biocompatibility of the complexes was investigated on a normal murine fibroblast cell line (L929), while the in vitro cytotoxicity of the compounds was evaluated on the human pancreatic cancer cell line MIA-PaCa-2 by the conventional MTT [3-(4,5-dimethylthiazol-2)-2,5diphenyl tetrazolium bromide] assay. 37 Briefly, 1 × 10 4 cells/mL were seeded in a flat-bottomed 96-well culture plate and incubated for 24 h at 37 °C and 5% CO 2 . A 1 mg/mL stock solution of compounds was prepared in DMSO.…”

Section: Biocompatibility and Anticancer Activity Of Complexesmentioning

confidence: 99%

Nickel Complexes Bearing ONS Chelating Ligands: A Promising Contender for In Vitro Cytotoxicity Effects on Human Pancreatic Cancer MIA-PaCa-2 Cells

Tanwar

Kaur

Kumar

et al. 2023

ACS Appl. Bio Mater.

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The highly chronic human pancreatic cancer cell is one of the major reasons for cancerous death. Nickel complexes are recently gaining interest in anticancer activities on different types of cancer cells. Hence, in this study, we synthesized and characterized a series of ONS donor ligands [2- 5), and [(L6−H) 2 Ni] (6). The singlecrystal X-ray diffraction data of complexes 1 and 4 were collected to elucidate the geometry around the metal center. The anticancer activity of complexes 1− 6 was investigated on human pancreatic cancer cell line MIA-PaCa-2, which revealed that complexes 4 and 6 were the most significantly effective in decreasing the cell viability of cancer cells at the lowest dose. The structure parameters obtained from singlecrystal X-ray diffraction data are found to be in good agreement with the data from density functional theory and Hirshfeld surface analysis for complex 1.

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Stemness, invasion, and immunosuppression modulation in recurrent glioblastoma using nanotherapy

Sarkar,

Greer,

Marlowe

et al. 2024

WIREs Nanomed Nanobiotechnol

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The recurrent nature of glioblastoma negatively impacts conventional treatment strategies leading to a growing need for nanomedicine. Nanotherapeutics, an approach designed to deliver drugs to specific sites, is experiencing rapid growth and gaining immense popularity. Having potential in reaching the hard‐to‐reach disease sites, this field has the potential to show high efficacy in combatting glioblastoma progression. The presence of glioblastoma stem cells (GSCs) is a major factor behind the poor prognosis of glioblastoma multiforme (GBM). Stemness potential, heterogeneity, and self‐renewal capacity, are some of the properties that make GSCs invade across the distant regions of the brain. Despite advances in medical technology and MRI‐guided maximal surgical resection, not all GSCs residing in the brain can be removed, leading to recurrent disease. The aggressiveness of GBM is often correlated with immune suppression, where the T‐cells are unable to infiltrate the cancer initiating GSCs. Standard of care therapies, including surgery and chemotherapy in combination with radiation therapy, have failed to tackle all the challenges of the GSCs, making it increasingly important for researchers to develop strategies to tackle their growth and proliferation and reduce the recurrence of GBM. Here, we will focus on the advancements in the field of nanomedicine that has the potential to show positive impact in managing glioblastoma tumor microenvironment.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Tailoring nanoparticles design for enhanced heating efficiency and improved magneto-chemo therapy for glioblastoma

Cited by 10 publications

References 71 publications

Self-propelling bacteria-based magnetic nanoparticles (BacMags) for targeted magnetic hyperthermia therapy against hypoxic tumors

Self-propelling bacteria-based magnetic nanoparticles (BacMags) for targeted magnetic hyperthermia therapy against hypoxic tumors

Nickel Complexes Bearing ONS Chelating Ligands: A Promising Contender for In Vitro Cytotoxicity Effects on Human Pancreatic Cancer MIA-PaCa-2 Cells

Stemness, invasion, and immunosuppression modulation in recurrent glioblastoma using nanotherapy

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