Tailoring micro/nano-fibers for biomedical applications

Kong, Bin; Liu, Rui; Guo, Jiahui; Lu, Ling; Zhou, Qing; Zhao, Yuanjin

doi:10.1016/j.bioactmat.2022.04.016

Cited by 53 publications

(48 citation statements)

References 222 publications

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“…Microfluidics technology, which is characterized by precise manipulation of fluids at the micro scale, has been exhibiting considerable promise in fabricating functional materials 37,47–50 . Onoe et al.…”

Section: Fabrication Strategymentioning

confidence: 99%

Responsive hydrogel microfibers for biomedical engineering

et al. 2022

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Responsive hydrogel microfibers can realize multiple controllable changes in shapes or properties under the stimulation of the surrounding environment, and are called as intelligent biomaterials. Recently, these responsive hydrogel microfibers have been proved to possess significant biomedical values, and remarkable progress has been achieved in biomedical engineering applications, including drug delivery, biosensors and clinical therapy, etc. In this review, the latest research progress and application prospects of responsive hydrogel microfibers in biomedical engineering are summarized. We first introduce the common preparation strategies of responsive hydrogel microfibers. Subsequently, the response characteristics and the biomedical applications of these materials are discussed. Finally, the present opportunities and challenges as well as the prospects for future development are critically analyzed.

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Section: Fabrication Strategymentioning

confidence: 99%

Responsive hydrogel microfibers for biomedical engineering

et al. 2022

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“…Electrospinning (ES) technology for preparing biodegradable polymer fibers has attracted extensive attention owing to a large specific surface area, high porosity, controllable fiber diameter, and good gas permeability of the materials obtained [ 1 , 2 , 3 , 4 , 5 ]. ES fiber mats can be widely used in tissue engineering, wound dressing, drug delivery systems, skin care, and other biomedical applications [ 3 , 4 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. The properties of the ES fiber mats, such as hydrophilicity, biocompatibility, biodegradability, cell interaction, and mechanical strength, are dependent on the chemical nature of the materials.…”

Section: Introductionmentioning

confidence: 99%

Chain-End Functionalization of Poly(ε-caprolactone) for Chemical Binding with Gelatin: Binary Electrospun Scaffolds with Improved Physico-Mechanical Characteristics and Cell Adhesive Properties

et al. 2022

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Composite biocompatible scaffolds, obtained using the electrospinning (ES) technique, are highly promising for biomedical application thanks to their high surface area, porosity, adjustable fiber diameter, and permeability. However, the combination of synthetic biodegradable (such as poly(ε-caprolactone) PCL) and natural (such as gelatin Gt) polymers is complicated by the problem of low compatibility of the components. Previously, this problem was solved by PCL grafting and/or Gt cross-linking after ES molding. In the present study, composite fibrous scaffolds consisting of PCL and Gt were fabricated by the electrospinning (ES) method using non-functionalized PCL1 or NHS-functionalized PCL2 and hexafluoroisopropanol as a solvent. To provide covalent binding between PCL2 and Gt macromolecules, NHS-functionalized methyl glutarate was synthesized and studied in model reactions with components of spinning solution. It was found that selective formation of amide bonds, which provide complete covalent bonding of Gt in PCL/Gt composite, requires the presence of weak acid. With the use of the optimized ES method, fibrous mats with different PCL/Gt ratios were prepared. The sample morphology (SEM), hydrolytic resistance (FT-IR), cell adhesion and viability (MTT assay), cell penetration (fluorescent microscopy), and mechanical characteristics of the samples were studied. PCL2-based films with a Gt content of 20 wt% have demonstrated the best set of properties.

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“…1−3 Fibers have been successfully used across a variety of fields, including electronics, cosmetics, pharmaceutical research, biomedical engineering, and tissue engineering. 4 For instance, fibers have been used for cell regulation studies, 5 for the manufacturing of muscle-like tissues, 6 or for drugrelease studies. 7,8 Microfluidics has played a pivotal role in facilitating production of fibers with controllable and homogeneous properties, compared to the most classic bulk techniques.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Fibers are long flexible materials having a diameter on the order of 10s of micrometers and a length of at least 1000 times their diameter . Fibers have seen an exponential growth in their use thanks to the advancement of micro/nanofabrication technologies. − Fibers have been successfully used across a variety of fields, including electronics, cosmetics, pharmaceutical research, biomedical engineering, and tissue engineering . For instance, fibers have been used for cell regulation studies, for the manufacturing of muscle-like tissues, or for drug-release studies. , …”

Section: Introductionmentioning

confidence: 99%

“…The current state-of the art , includes fibers having different shapes but made of a single material, − fibers loaded with cells to enable formation of tissues, ,, fibers loaded with nanoparticles, or nonspherical nanometer-sized objects . The main limitation faced by fibers containing either cells or particles is the fact that their distribution within the fiber is stochastic, as it is not possible to insert them uniformly.…”

Section: Introductionmentioning

confidence: 99%

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Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation

Maisto

McDowall

Adams

et al. 2022

ACS Appl. Eng. Mater.

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Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers having heterogeneous properties along their length. We here introduce a new class of material featuring fibers loaded with “equally spaced” microparticles. The fibers were obtained thanks to the combination between the recently discovered viscoelastic particle ordering phenomenon and the well-established process of fiber synthesis via ex situ ionic gelation. We employed a simple experimental apparatus made of a syringe pump connected to a 100 μm tube ending in a calcium chloride bath. The liquid forming the fiber was an aqueous solution of hyaluronic acid and sodium alginate. We studied the effect of volumetric flow rate, sodium alginate concentration, and spinning speed on the fiber diameter and the particle-spacing in the fiber. We also discussed the advantages of this type of fiber over the existing ones and suggested potential applications across several fields.

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Tailoring micro/nano-fibers for biomedical applications

Cited by 53 publications

References 222 publications

Responsive hydrogel microfibers for biomedical engineering

Responsive hydrogel microfibers for biomedical engineering

Chain-End Functionalization of Poly(ε-caprolactone) for Chemical Binding with Gelatin: Binary Electrospun Scaffolds with Improved Physico-Mechanical Characteristics and Cell Adhesive Properties

Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation

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