Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery

Tansık, Gülistan; Yakar, Arzu; Gündüz, Ufuk

doi:10.1007/s11051-013-2171-7

Cited by 35 publications

(27 citation statements)

References 33 publications

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“…The cellular viability of free OXC was 89.84 and 75.2% for 1 and 100 μg/ml concentrations, respectively. The cellular viability of drug free PLGA nanoparticles was more than 90% even at the highest concentration indicating the biocompatibility of PLGA and no residue of organic solvent with an accordance to previous literature (Tansık, Yakar, & Gündüz, ). Moreover, for each concentration level, cells treated with oxaceprol‐loaded nanoparticles exhibited higher viability than those cells treated with free oxaceprol.…”

Section: Resultssupporting

confidence: 91%

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Alarçin

Demirbağ

Karslı-Çeppioğlu

et al. 2020

Drug Development Research

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Oxaceprol is well-defined therapeutic agent as an atypical inhibitor of inflammation in osteoarthritis. In the present study, we aimed to develop and characterize oxaceprol-loaded poly-lactide-co-glycolide (PLGA) nanoparticles for intra-articular administration in osteoarthritis. PLGA nanoparticles were prepared by doubleemulsion solvent evaporation method. Meanwhile, a straightforward and generally applicable high performance liquid chromatography method was developed, and validated for the first time for the quantification of oxaceprol. To examine the drug carrying capacity of nanoparticles, varying amount of oxaceprol was entrapped into a constant amount of polymer matrix. Moreover, the efficacy of drug amount on nanoparticle characteristics such as particle size, zeta potential, morphology, drug entrapment, and in vitro drug release was investigated. Nanoparticle sizes were between 229 and 509 nm for different amount of oxaceprol with spherical smooth morphology. Encapsulation efficiency ranged between 39.73 and 63.83% by decreasing oxaceprol amount. The results of Fourier transform infrared and DSC showed absence of interaction between oxaceprol and PLGA. The in vitro drug release from these nanoparticles showed a sustained release of oxaceprol over 30 days. According to cell culture studies, oxaceprol-loaded nanoparticles had no cytotoxicity with high biocompatibility. This study was the first step of developing an intra-articular system in the treatment of osteoarthritis for the controlled release of oxaceprol. Our findings showed that these nanoparticles can be beneficial for an effective treatment of osteoarthritis avoiding side effects associated with oral administration. K E Y W O R D Sintra-articular injection, nanoparticle, osteoarthritis, oxaceprol, PLGA

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Section: Resultssupporting

confidence: 91%

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Alarçin

Demirbağ

Karslı-Çeppioğlu

et al. 2020

Drug Development Research

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“… The exclusive structure of PLGA nanoparticles, composed of a hydrophilic surface and a hydrophobic core, provides a drug carrying reservoir and also enables them to dissolve in aqueous solutions [ 6 ]. The by-products of PLGA are the lactic acid and glycolic acid, can be excreted from the body as water and carbon-dioxide through the tricarboxylic acid cycle [ 7 , 8 ]. The most remarkable one is probably the carrier delivery system that encapsulates active ingredients and releases them under a controlled mechanism [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The by-products of PLGA are the lactic acid and glycolic acid, can be excreted from the body as water and carbon-dioxide through the tricarboxylic acid cycle [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study

2016

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Nanoparticles formulated from biodegradable polymers like poly(lactic-co-glycolic acid) (PLGA) are being extensively investigated as drug delivery systems due to their two important properties such as biocompatibility and controlled drug release characteristics. The aim of this work to formulated diazepam loaded PLGA nanoparticles by using emulsion solvent evaporation technique. Polyvinyl alcohol (PVA) is used as stabilizing agent. Diazepam is a benzodiazepine derivative drug, and widely used as an anticonvulsant in the treatment of various types of epilepsy, insomnia and anxiety. This work investigates the effects of some preparation variables on the size and shape of nanoparticles prepared by emulsion solvent evaporation method. These nanoparticles were characterized by photon correlation spectroscopy (PCS), transmission electron microscopy (TEM). Zeta potential study was also performed to understand the surface charge of nanoparticles. The drug release from drug loaded nanoparticles was studied by dialysis bag method and the in vitro drug release data was also studied by various kinetic models. The results show that sonication time, polymer content, surfactant concentration, ratio of organic to aqueous phase volume, and the amount of drug have an important effect on the size of nanoparticles. Hopefully we produced spherical shape Diazepam loaded PLGA nanoparticles with a size range under 250 nm with zeta potential −23.3 mV. The in vitro drug release analysis shows sustained release of drug from nanoparticles and follow Korsmeyer-Peppas model.

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“…Fe 3 O 4 -MPTMS-PLGA nanocomposites were prepared by single oil in water emulsion method (o/w) with slight modifications (Ashjari et al 2011, Tansik et al 2014. Surfacemodified Fe 3 O 4 nanoparticles were dispersed in DCM using an ultrasonic probe, and the dispersion was mixed with an organic solution of PLGA in DCM in an ice bath (Fe 3 O 4 -MPTMS/PLGA ratio 1/1-1/20).…”

Section: Synthesis Of Fe 3 O 4 -Mptms-plga Nanocompositesmentioning

confidence: 99%

Synthesis and characterization of Fe₃O₄-MPTMS-PLGA nanocomposites for anticancer drug loading and release studies

Dinçer

Yıldız

Karakeçili

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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Magnetic nanocomposites (FeO-MPTMS-PLGA) were synthesized by single oil emulsion method and characterized by transmission electron microscopy (TEM), X-Ray diffraction (XRD), and vibrating sample magnetometer (VSM). Particle size of nanocomposites was between 117 nm and 246 nm. High performance liquid chromatography (HPLC) was used to investigate drug loading (paclitaxel, PTX) and release from FeO-MPTMS-PLGA-PTX nanocomposites. The percentages of drug loading and encapsulation efficiency onto nanocomposites were found as 7.35 and 68.58, respectively. Cytotoxities of free anticancer drug and anticancer drug-loaded nanocomposites were determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. In vitro cell culture studies indicated that FeO-MPTMS-PLGA-PTX had significant toxicity on MG-63 cancer cells.

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Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery

Cited by 35 publications

References 33 publications

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study

Synthesis and characterization of Fe₃O₄-MPTMS-PLGA nanocomposites for anticancer drug loading and release studies

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Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery

Cited by 35 publications

References 33 publications

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study

Synthesis and characterization of Fe3O4-MPTMS-PLGA nanocomposites for anticancer drug loading and release studies

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Synthesis and characterization of Fe₃O₄-MPTMS-PLGA nanocomposites for anticancer drug loading and release studies