Tailoring functional nanostructured lipid carriers for glioblastoma treatment with enhanced permeability through in-vitro 3D BBB/BBTB models

Zwain, Tamara; Alder, Jane; Sabagh, Bassem; Shaw, Andrew; Burrow, Andrea Julie; Singh, Kamalinder K.

doi:10.1016/j.msec.2020.111774

Cited by 32 publications

(14 citation statements)

References 97 publications

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“…The particles were polydisperse: modal sizes were 109.4 and 126.5 nm for THC-SLNs and blank SLNs, respectively. This is in line with previous reports showing larger particles for blank nanostructured lipid carriers (NLCs) due to their lack of a dense drug core [45,46]. FTIR was used to investigate the interplay and interactions between drug and lipid during the preparation of SLNs (Figure 2).…”

Section: Nanoparticle Tracking Analysis (Nta)supporting

confidence: 85%

Tetrahydrocurcumin Lipid Nanoparticle Based Gel Promotes Penetration into Deeper Skin Layers and Alleviates Atopic Dermatitis in 2,4-Dinitrochlorobenzene (DNCB) Mouse Model

et al. 2022

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Treatment of atopic dermatitis (AD) is challenging due to its complex pathophysiology. Tetrahydrocurcumin (THC) a polyphenolic, colorless compound that is more polar than curcumin. It possesses superior anti-inflammatory properties and has a clinical advantage over curcumin. The present study investigated the therapeutic effectiveness of THC solid lipid nanoparticle (THC-SLN)-based gels in AD. THC-SLNs prepared using microemulsification resulted in a particle size of 109.2 nm as determined by nanoparticle tracking, and FTIR confirmed the entrapment of drug within the lipid matrix. THC-SLNs greatly enhanced skin hydration when tested both ex vivo and in vivo in Lacca mice. Deeper skin penetration was clearly established using dermatokinetics and CLSM. The in vivo pharmacodynamics of THC-SLNs gel in 2,4-dinitrochlorobenzene (DNCB)-induced AD mice showed enhanced bioactivity; reduced levels of TNF-α and IL-6; and complete healing, as evident from histopathological studies. Thus, the novel topical THC-SLN gel has potential to emerge as a safe alternative to conventional corticosteroids for AD and other skin disorders with overbearing inflammation.

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Section: Nanoparticle Tracking Analysis (Nta)supporting

confidence: 85%

Tetrahydrocurcumin Lipid Nanoparticle Based Gel Promotes Penetration into Deeper Skin Layers and Alleviates Atopic Dermatitis in 2,4-Dinitrochlorobenzene (DNCB) Mouse Model

et al. 2022

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“…However, those with PDI values more than 0.5 are described as heterogeneous and polydispersed (broad distribution). In most cases, PDI values less than 0.3 are considered the optimum for SLNs and NLCs [107].…”

Section: Particle Sizementioning

confidence: 99%

Lipid nanostructures for targeting brain cancer

Nsairat

Khater

Odeh

et al. 2021

Heliyon

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Advancements in both material science and bionanotechnology are transforming the health care sector. To this end, nanoparticles are increasingly used to improve diagnosis, monitoring, and therapy. Huge research is being carried out to improve the design, efficiency, and performance of these nanoparticles. Nanoparticles are also considered as a major area of research and development to meet the essential requirements for use in nanomedicine where safety, compatibility, biodegradability, biodistribution, stability, and effectiveness are requirements towards the desired application. In this regard, lipids have been used in pharmaceuticals and medical formulations for a long time. The present work focuses on the use of lipid nanostructures to combat brain tumors. In addition, this review summarizes the literature pertaining to solid lipid nanoparticles (SLN) and nanostructured lipid carriers (LNC), methods of preparation and characterization, developments achieved to overcome blood brain barrier (BBB), and modifications used to increase their effectiveness.

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“…Recent and innovative works with DTX in NLC have been reported, such as that by Zwain et al [41] in which pegylated NLC were prepared by changing the concentrations or combining liquid lipids (Labrasol, Lauroglycol 90, Capryol and Kolliphor HS15) to enhance drug permeability through the blood-brain barrier (BBB). For the treatment of glioblastoma, the authors used 3D BBB/blood-brain tumour barrier (BBTB) in vitro models and combined optimised formulations with four liquid lipids at low concentrations to increase permeation to the central nervous system.…”

Section: Cabazitaxelmentioning

confidence: 99%

Antineoplastics Encapsulated in Nanostructured Lipid Carriers

et al. 2021

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Ideally, antineoplastic treatment aims to selectively eradicate cancer cells without causing systemic toxicity. A great number of antineoplastic agents (AAs) are available nowadays, with well-defined therapeutic protocols. The poor bioavailability, non-selective action, high systemic toxicity, and lack of effectiveness of most AAs have stimulated the search for novel chemotherapy protocols, including technological approaches that provide drug delivery systems (DDS) for gold standard medicines. Nanostructured lipid carriers (NLC) are DDS that contain a core of solid and lipid liquids stabilised by surfactants. NLC have high upload capacity for lipophilic drugs, such as the majority of AAs. These nanoparticles can be prepared with a diversity of biocompatible (synthetic or natural) lipid blends, administered by different routes and functionalised for targeting purposes. This review focused on the research carried out from 2000 to now, regarding NLC formulations for AAs (antimetabolites, antimitotics, alkylating agents, and antibiotics) encapsulation, with special emphasis on studies carried out in vivo. NLC systems for codelivery of AAs were also considered, as well as those for non-classical drugs and therapies (natural products and photosensitisers). NLC have emerged as powerful DDS to improve the bioavailability, targeting and efficacy of antineoplastics, while decreasing their toxic effect in the treatment of different types of cancer.

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Tailoring functional nanostructured lipid carriers for glioblastoma treatment with enhanced permeability through in-vitro 3D BBB/BBTB models

Cited by 32 publications

References 97 publications

Tetrahydrocurcumin Lipid Nanoparticle Based Gel Promotes Penetration into Deeper Skin Layers and Alleviates Atopic Dermatitis in 2,4-Dinitrochlorobenzene (DNCB) Mouse Model

Tetrahydrocurcumin Lipid Nanoparticle Based Gel Promotes Penetration into Deeper Skin Layers and Alleviates Atopic Dermatitis in 2,4-Dinitrochlorobenzene (DNCB) Mouse Model

Lipid nanostructures for targeting brain cancer

Antineoplastics Encapsulated in Nanostructured Lipid Carriers

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