Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques

Genina, Natalja; Fors, Daniela; Vakili, Hossein; Ihalainen, Petri; Pohjala, Leena; Ehlers, Henrik; Kassamakov, Ivan; Hæggström, Edward; Vuorela, Pia; Peltonen, Jouko; Sandler, Niklas

doi:10.1016/j.ejps.2012.07.020

Cited by 120 publications

(75 citation statements)

References 27 publications

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“…viscosity modifiers, co-solvents etc.) can improve the specific printability parameters of drug-containing ink solutions such as surface tension and viscosity as well as final properties of the printed dosage forms (drug distribution and stability) (Di Risio and Yan, 2007;Genina et al, 2012;Wickström et al, 2015). For sufficient loading of poorly soluble drugs, the ink formulations needs to be modified accordingly (non-aqueous solutions, nano-suspensions, lipidic formulations) (Williams et al, 2013).…”

Section: Inkjet Printing For Personalised Odf Manufacturing: Unmet Needsmentioning

confidence: 99%

Orodispersible films: Towards drug delivery in special populations

Scarpa

Stegemann

Hsiao

et al. 2017

International Journal of Pharmaceutics

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Section: Inkjet Printing For Personalised Odf Manufacturing: Unmet Needsmentioning

confidence: 99%

Orodispersible films: Towards drug delivery in special populations

Scarpa

Stegemann

Hsiao

et al. 2017

International Journal of Pharmaceutics

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“…Such checks should be non-destructive, fast and cheap. Takala et al (2012) and Genina et al (2012) both dispensed a riboflavin ink formulation, which is an orange coloured solution. The colour was used to visualise the deposited solution and might be used to quantify the dose deposited.…”

Section: Dose Confirmationmentioning

confidence: 99%

“…The compatibility between the chosen glycol and the jetting liquid should be inspected. Genina et al (2012) found that riboflavin, which is highly soluble in water, precipitated in the presence of polyethylene glycol; glycerol was thus used instead. An additional benefit of using glycols is their role in reducing the evaporation of the solvent, as they act as humectants (Raijada et al, 2014).…”

Section: Before Printingmentioning

confidence: 99%

“…(2014) Hydroxypropyl methyl cellulose (HPMC) filmsRaijada et al (2013) Edible icing sheetsSandler et al (2011) Uncoated paper, coated paper, and polyethylene terephthalate (PET) filmScoutaris et al (2011) Glass cover slip coated in flutec fluid to increase hydrophobicityGenina et al (2013a) Orodispersible films, copy paper, water impermeable transparency filmsGenina et al (2013b) Icing sheet, PET film, HPC filmBuanz et al (2011) Clear acetate film, starch filmGenina et al (2012) Uncoated wood-free paper, triple-coated inkjet paper, double-coated sheetMeléndez et al (2008) PTFE films over a clear transparency filmTakala et al (2012) …”

mentioning

confidence: 99%

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Personalised dosing: Printing a dose of one’s own medicine

Alomari

Mohamed

Basit

et al. 2015

International Journal of Pharmaceutics

211

122

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“…To summarize, printing a drug on dosage form is the latest breakthrough in film development and proved to be a powerful tool to manufacture dosage form with excellent uniformity, unique speed-ability, and high stability. [77] EVALUATION PARAMETERS…”

Section: Printing Technologiesmentioning

confidence: 99%

Untitled

Verma¹

2018

IJGP

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Considering the compliance of patients and ease of administration, the oral cavity is profoundly chosen to deliver drugs. This article focuses on mucoadhesive buccal drug delivery system providing sustained release of the drug. The drug of choice for buccal delivery is those which undergoes high first-pass metabolism or undergo acid degradation. This review article aims to focus on various aspects of buccal films, factors affecting mucoadhesion and its evaluating parameters. Different theories involved in mucoadhesion process and along with the polymers that are involved in developing different categories of films have been focused. Factors influencing the polymers involved flexibility, molecular weight, charge, etc., are also considered in this review. Most commonly used polymers in the development of mucoadhesive films are lectins, starch, pectins, and cellulose derivatives, etc. Several agents such as penetration enhancers and mucoadhesive agents are employed to develop an ideal film. These dosage forms are formulated using two processes, namely film casting method and hot-melt extrusion method. The developed films are evaluated based on multiple parameters such as surface pH, flatness, tensile strength, and peel strength. This review gives an overall view of different polymers that are used to develop the mucoadhesive films and compare their degree of mucoadhesion along with their parametric tests to evaluate the developed films.

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Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques

Cited by 120 publications

References 27 publications

Orodispersible films: Towards drug delivery in special populations

Orodispersible films: Towards drug delivery in special populations

Personalised dosing: Printing a dose of one’s own medicine

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