Tailoring Cellular Uptake of Gold Nanoparticles Via the Hydrophilic‐to‐Hydrophobic Ratio of their (Co)polymer Coating

Zhang, Zhiyue; Steendam, Katleen Van; Maji, Samarendra; Balcaen, Lieve; Anoshkina, Yulia; Zhang, Qilu; Vanluchene, Glenn; Rycke, Riet De; Haecke, Frank Van; Deforce, Dieter; Hoogenboom, Richard; Geest, Bruno G. De

doi:10.1002/adfm.201500904

Cited by 17 publications

(13 citation statements)

References 44 publications

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“…It can be noticed that the heat released by the Ag nanofluid under sunlight irradiation at the plasmonic- The reason behind selecting Ag NPs for this purpose is that Ag NPs, after Au NPs, are the best candidate for the plasmonic heating generation process [117]. Meanwhile, in semiconductor NPs, the heat release rate is much weaker since heat is produced over the interband absorption procedure with the formation of mobile electrons and holes [121].…”

Section: Solar Energy Harvesting Using Ag Npsmentioning

confidence: 99%

Biosynthesis of Silver Nanoparticles and Their Applications in Harvesting Sunlight for Solar Thermal Generation

et al. 2021

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Silver (Ag) nanoparticles (NPs) have been synthesized through an easy, inexpensive, and ecofriendly method. Petroselinum crispum, parsley, leaf extract was utilized as a reducing, capping, and stabilizing agent, without using any hazardous chemical materials, for producing Ag NPs. The biosynthesized Ag NPs were characterized using different characterization techniques, namely UV-Vis, FT-IR spectroscopy, X-ray diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), dynamic light scattering (DLS), zeta potential, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), transmission electron microscope (TEM), field emission scanning electron microscopy (FESEM), and energy-dispersive X-ray (EDX) analysis to investigate the optical, thermal, structural, morphological, and chemical properties of the plant extract and the biosynthesized Ag NPs. After that, the biosynthesized Ag NPs were utilized in harvesting sunlight for solar thermal generation. Surface plasmon resonance (SPR) for the green synthesized Ag NPs with the dark color were adjusted at nearly 450 nm. Once the Ag NPs are excited at the SPR, a large amount of heat is released, which causes a change in the local refractive index surrounding the Ag NPs. The released heat from the Ag NPs under the solar irradiation at the precise wavelength of plasmon resonance significantly increased the temperature of the aqueous medium. Different percentages of Ag NPs were dispersed in water and then exposed to the sunlight to monitor the temperature of the suspension. It was found that the temperature of the aqueous medium reached its highest point when 0.3 wt. % of Ag NPs was utilized. This investigation is rare and unique, and it shows that utilizing a small amount of the biosynthesized Ag NPs can increase the temperature of the aqueous medium remarkably.

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Section: Solar Energy Harvesting Using Ag Npsmentioning

confidence: 99%

Biosynthesis of Silver Nanoparticles and Their Applications in Harvesting Sunlight for Solar Thermal Generation

et al. 2021

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“…Therefore, a well-defined and stable interface with immobilized surfactants on a hydrophobic carrier surface would be advantageous to prevent NC protein aggregation ( 41 ). On the other hand, hydrophobicity can also be utilized to control protein adsorption on the nano-bio-interface specifically, as demonstrated by Zhang et al who covalently deposited (co-)polymers of varying amphiphilicity on gold NC and observed a variation in protein adsorption affording tailored cellular NC uptake ( 42 ).…”

Section: The Protein Corona Around Nc As a Confounding Variable For Ementioning

confidence: 99%

The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery

et al. 2018

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Nanocarriers (NC) are very promising tools for cancer immunotherapy. Whereas conventional vaccines are based on the administration of an antigen and an adjuvant in an independent fashion, nanovaccines can facilitate cell-specific co-delivery of antigen and adjuvant. Furthermore, nanovaccines can be decorated on their surface with molecules that facilitate target-specific antigen delivery to certain antigen-presenting cell types or tumor cells. However, the target cell-specific uptake of nanovaccines is highly dependent on the modifications of the nanocarrier itself. One of these is the formation of a protein corona around NC after in vivo administration, which may potently affect cell-specific targeting and uptake of the NC. Understanding the formation and composition of the protein corona is, therefore, of major importance for the use of nanocarriers in vaccine approaches. This Mini Review will give a short overview of potential non-specific interactions of NC with body fluids or cell surfaces that need to be considered for the design of NC vaccines for immunotherapy of cancer.

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“…Among numerous NPs, gold NPs (AuNPs) in particular have attracted plenty of interest due to their chemical stability, easily modified surface chemistry and tunable optical properties. [26][27][28][29][30] AuNPs are usually modified with biocompatible molecules such as polyethylene glycol (PEG) to improve their biocompatibility and to prevent aggregation. 31,32 Thiol-end PEG can be easily bound onto the surfaces of AuNPs through gold-thiol interactions.…”

Section: Introductionmentioning

confidence: 99%

Influence of cell size on cellular uptake of gold nanoparticles

Wang

et al. 2016

Biomater. Sci.

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Nanoparticles (NPs) have shown great potential for biomedical applications because of their unique physical and structural properties. A critical aspect for their clinical applications is cellular uptake that depends on both particle properties and the cell mechanical state. Despite the numerous studies trying to disclose the influencing factors, the role of cell size on cellular uptake remains unclear. In this study, poly(vinyl alcohol) was micropatterned on tissue culture polystyrene surfaces using UV photolithography to control the cell size, and the influence of cell size on the cellular uptake of gold NPs was investigated. Cells with a large size had a high total cellular uptake, but showed a low average uptake per unit area of cells. Cells with a small size showed opposite behaviors. The results were related to both cell/NP contacting area and membrane tension. A large cell size was beneficial for a high total cellular uptake due to the large contact area with the NPs. On the other hand, the large cell size resulted in high membrane tension that required high wrapping energy for engulfing of NPs and thus reduced the uptake. The two oppositely working effects decided the cellular uptake of NPs. The results would shed light on the influence of the cellular microenvironment on cellular uptake behavior.

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Tailoring Cellular Uptake of Gold Nanoparticles Via the Hydrophilic‐to‐Hydrophobic Ratio of their (Co)polymer Coating

Cited by 17 publications

References 44 publications

Biosynthesis of Silver Nanoparticles and Their Applications in Harvesting Sunlight for Solar Thermal Generation

Biosynthesis of Silver Nanoparticles and Their Applications in Harvesting Sunlight for Solar Thermal Generation

The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery

Influence of cell size on cellular uptake of gold nanoparticles

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