“…These nanodiscs, also called SMA-lipid particles, are relatively stable and do not need the presence of a free soluble copolymer in the solution. Similar to detergents, the membrane raft–associated proteins are not fully solubilized by SMA or other similar copolymers and remain in larger copolymer-resistant membrane fragments ( 7 , 8 ). The proteins contained in the nanodiscs thus behave essentially like soluble (lipo)proteins.…”