Tailoring bismuth-based nanoparticles for enhanced radiosensitivity in cancer therapy

Wen, Shuangchun; Ovais, Muhammad; Li, Xiaoyan; Ren, Jiayu; Liu, Tao; Wang, Ziyao; Cai, Rong; Chen, Chunying

doi:10.1039/d2nr01500e

Cited by 15 publications

(9 citation statements)

References 86 publications

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“…39 As an alternative option, metal-based nanomaterials, especially high-Z materials (eg, Au, bismuth, platinum, gadolinium), have been used in experimental and clinical applications as common radiosensitizers. [40][41][42] Owing to the emission of low-energy photoelectrons and the interaction of Auger electrons, high-Z nanomaterials can absorb, scatter, and eradicate radiation energy. Moreover, when compared with other metal-based nanomaterials, Au-based nanomaterials are most widely used for this purpose, owing to the following advantages it offers: 1) a strong X-ray attenuation 1960 capability that makes it suitable for use in computer tomography (CT) imaging contrast agent and radiosensitizer [43][44][45] ; 2) as it can be easily surface-modified and embedded in structures such as liposomes and polymer particles, it is frequently used in different tumor treatment protocols; 3) as an inert metal, it exhibits good biocompatibility and low biotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Albumin-Modified Gold Nanoparticles as Novel Radiosensitizers for Enhancing Lung Cancer Radiotherapy

Chen¹,

Liu²,

Yin³

et al. 2023

IJN

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Background Considering the strong attenuation of photons and the potential to increase the deposition of radiation, high-atomic number nanomaterials are often used as radiosensitizers in cancer radiotherapy, of which gold nanoparticles (GNPs) are widely used. Materials and Methods We prepared albumin-modified GNPs (Alb-GNPs) and observed their radiosensitizing effects and biotoxicity in human non-small-cell lung carcinoma tumor-bearing mice models. Results The prepared nanoparticles (Alb-GNPs) demonstrated excellent colloidal stability and biocompatibility at the mean size of 205.06 ± 1.03 nm. Furthermore, clone formation experiments revealed that Alb-GNPs exerted excellent radiosensitization, with a sensitization enhancement ratio (SER) of 1.432, which is higher than X-ray alone. Our in vitro and in vivo data suggested that Alb-GNPs enabled favorable accumulation in tumors, and the combination of Alb-GNPs and radiotherapy exhibited a relatively greater radiosensitizing effect and anti-tumor activity. In addition, no toxicity or abnormal irritating response resulted from the application of Alb-GNPs. Conclusion Alb-GNPs can be used as an effective radiosensitizer to improve the efficacy of radiotherapy with minimal damage to healthy tissues.

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Section: Discussionmentioning

confidence: 99%

Albumin-Modified Gold Nanoparticles as Novel Radiosensitizers for Enhancing Lung Cancer Radiotherapy

Chen¹,

Liu²,

Yin³

et al. 2023

IJN

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“…With the help of DP‐BNF@Lat‐MPs as a radiosensitizer and PTT agent, combination therapy could generate excessive levels of ROS which directly damage DNA double strands and induce tumor cell apoptosis. [ 41 ] Moreover, the hypoxic tumor microenvironment limits the therapeutic efficiency of PTT and radiotherapy. The BNFs with the incomplete reduction of Bi 2 O 3 form the nanoflower structure which has the specific Z‐scheme heterostructure and improves the electronic transmission.…”

Section: Discussionmentioning

confidence: 99%

“Cluster Bomb” Based Bismuth Nano‐in‐Micro Spheres Formed Dry Powder Inhalation for Thermo‐Radio Sensitization Effects of Lung Metastatic Breast Cancer

Wang

Chen

Miao

et al. 2023

Adv Healthcare Materials

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Lung metastatic breast cancer (LMBC) is mainly diagnosed through CT imaging and radiotherapy could be the most common method in the clinic to inhibit tumor proliferation. While the sensitivity of radiotherapy is always limited due to the hypoxic tumor microenvironment and high doses of irradiation easily induce systemic cytotoxicity. Metal‐based materials applied as radiosensitizers have been widely investigated to improve efficiency and reduce the doses of irradiation. Herein, it is aimed to overcome these problems by designing biodegradable lipid‐camouflaged bismuth‐based nanoflowers (DP‐BNFs) as both a photo‐thermo‐radiosensitizer to develop a novel photothermal therapy (PTT) and radiotherapy combination strategy for LMBC treatment. To achieve effective lung deposition, “Cluster Bomb” structure‐based DP‐BNFs nano‐in‐micro dry powder inhalation (DP‐BNF@Lat‐MPs) are formulated through spray‐dried technology. The DP‐BNFs “cluster” in the microsphere to improve their tumor‐targeted lung deposition with a high fine particle fraction followed by burst releasing of DP‐BNFs for targeting delivery and LMBC therapy. The DP‐BNF@Lat‐MPs exhibit excellent photothermal conversion efficiency, radiotherapy enhancement, and CT imaging ability in vitro, which synergistically inhibit cell proliferation and metastasis. In vitro and in vivo data prove that combining PTT and radiotherapy with DP‐BNF@Lat‐MPs as a thermo‐radio dual‐sensitizer significantly enhances LMBC tumor metastasis inhibition with good biocompatibility and low toxicity.

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Section: Introductionmentioning

confidence: 99%

“…Currently, numerous nanoparticles (NPs) have been developed for effective RT, which can inhibit tumor growth by enhancing the deposition of radiation energy in cells, and then target the ROS with their killing effects, leading to excellent radiotherapy sensitivity. [13][14][15][16] In glioma therapy, conventional chemotherapy methods can easily cause hematological toxicity and even induce epilepsy. The structural redesign of traditional chemotherapeutic drugs and improvement of dosage can reduce toxicity and side effects, thereby enhancing the efficacy of the drugs.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Nano-Realgar Hydrogel for Enhanced Glioblastoma Synergistic Chemotherapy and Radiotherapy: A New Paradigm of an Old Drug

Wang¹,

Wei²,

Wu³

et al. 2023

IJN

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Purpose Realgar, as a kind of traditional mineral Chinese medicine, can inhibit multiple solid tumor growth and serve as an adjuvant drug in cancer therapy. However, the extremely low solubility and poor body absorptive capacity limit its application in clinical medicine. To overcome this therapeutic hurdle, realgar can here be fabricated into a nano-realgar hydrogel with enhanced chemotherapy and radiotherapy (RT) ability. Our objective is to evaluate the superior biocompatibility and anti-tumor activity of nano-realgar hydrogel. Methods We have successfully synthesized nano-realgar quantum dots (QDs) coupling with 6-AN molecules (NRA QDs) and further encapsulated with a pH-sensitive dextran hydrogel carrier with hyaluronic acid coating (DEX-HA gel) to promote bioavailability, eventually forming a multifunctional nano-realgar hydrogel (NRA@DH Gel). To better investigate the tumor therapy efficiency of the NRA@DH Gel, we have established the mice in situ bearing GL261 brain glioblastoma as animal models assigned to receive intratumor injection of NRA@DH Gel. Results The designed NRA@DH Gel as an antitumor drug can not only exert the prominent chemotherapy effect but also as a “sustainable reactive oxygen species (ROS) generator” can inhibit in the pentose phosphate pathway (PPP) metabolism and reduce the production of nicotinamide adenine dinucleotide phosphate (NADPH), thereby inhibiting the conversion of glutathione disulfide (GSSG) to glutathione (GSH), reducing GSH concentrations in tumor cells, triggering the accumulation of ROS, and finally enhancing the effectiveness of RT. Conclusion Through the synergistic effect of chemotherapy and RT, NRA@DH Gel effectively inhibited the proliferation and migration of tumor cells, suppressed tumor growth, improved motor coordination, and prolonged survival in tumor-bearing mice. Our work aims to improve the NRA@DH Gel-mediated synergistic chemotherapy and RT will endow a “promising future” for the old drug in clinically comprehensive applications.

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Tailoring bismuth-based nanoparticles for enhanced radiosensitivity in cancer therapy

Abstract: Complete response to cancer treatment is an important challenge that has puzzled mankind. Fortunately, radiotherapy gives rise to a common clinical treatment method, during which the usage of radio-sensitizers is...

Cited by 15 publications

References 86 publications

Albumin-Modified Gold Nanoparticles as Novel Radiosensitizers for Enhancing Lung Cancer Radiotherapy

Albumin-Modified Gold Nanoparticles as Novel Radiosensitizers for Enhancing Lung Cancer Radiotherapy

“Cluster Bomb” Based Bismuth Nano‐in‐Micro Spheres Formed Dry Powder Inhalation for Thermo‐Radio Sensitization Effects of Lung Metastatic Breast Cancer

Multifunctional Nano-Realgar Hydrogel for Enhanced Glioblastoma Synergistic Chemotherapy and Radiotherapy: A New Paradigm of an Old Drug

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