Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media

Jeong, Kyung Min; Lee, Min Sang; Nam, Min Woo; Zhao, Jing; Jin, Yan; Lee, Dong Kyu; Kwon, Sung Won; Jeong, Ji Hoon; Lee, Jeongmi

doi:10.1016/j.chroma.2015.10.083

Cited by 161 publications

(80 citation statements)

References 54 publications

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“…Pioneering works have indicated that DES pretreatment can significantly promote the efficacy of residue cellulose enzymatic hydrolysis. The plant species, which on the pretreatment with different DESs, have been extended to gramineae [corncob (Procentese et al, 2015;Zhang et al, 2016), wheat straw (Jeong et al, 2015), sorghum (Das et al, 2018), and switchgrass (Chen et al, 2018;Kim et al, 2018)], hardwood [eucalyptus (Shen et al, 2019), willow (Lyu et al, 2018;Song et al, 2019), and poplar (Alvarez-Vasco et al, 2016;Liu et al, 2017)], softwood [pine (Lynam et al, 2017), spruce (Wahlström et al, 2016), and fir (Alvarez-Vasco et al, 2016)], and endocarp (Li et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Unraveling the Structural Transformation of Wood Lignin During Deep Eutectic Solvent Treatment

Wang

Xiao

et al. 2020

Front. Energy Res.

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Deep eutectic solvents (DESs) can efficiently promote the efficiency of cellulose enzymatic hydrolysis through the removal of lignin component in lignocellulosic biomass pretreatment. Unraveling the fundamental structural variant of lignin during DES treatment would facilitate to understand the DES-based biomass pretreatment in a clear perspective. Herein, an enzymatic mild acidolysis lignin (EMAL) and a series of β-O-4 lignin model compounds were employed to be treated with choline chloride (ChCl)/lactic acid (LA) (1:2) DES, from which the structural variant of all lignin fractions can be realized in a detailed version. The β-O-4 linkages, existing in either realistic lignin or model compounds, could be cleaved by ChCl/LA, thus leading to the decrease of molecular weight and the rise of hydroxyl groups. The influence of reaction temperature and time was also examined in view of some key structural parameters. Experimental evidences from model compounds confirmed that the repolymerization occurs with the depolymerization of lignin, which may account for the low production of monomeric products during DES treatment.

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Section: Introductionmentioning

confidence: 99%

Unraveling the Structural Transformation of Wood Lignin During Deep Eutectic Solvent Treatment

Wang

Xiao

et al. 2020

Front. Energy Res.

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“…All DES were tested as 75% (w/v) aqueous solutions, using an average water content of those previously reported for polyphenol extraction with DES [21,23]. Appropriate amounts of water are considered critical for DES extraction efficiency, given the usually high DES viscosity.…”

Section: Extraction Efficiencymentioning

confidence: 99%

Combination of Lactic Acid-Based Deep Eutectic Solvents (DES) with β-Cyclodextrin: Performance Screening Using Ultrasound-Assisted Extraction of Polyphenols from Selected Native Greek Medicinal Plants

et al. 2017

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Abstract:A series of novel L-lactic acid-based deep eutectic solvents (DES) were tested for polyphenol extraction performance, using organically grown, native Greek medicinal plants. The extractions were ultrasonically-assisted and the effect of the addition of β-cyclodextrin (β-CD) as extraction booster was also tested, at a concentration of 1.5% (w/v). The estimation of total polyphenol yield (Y TP ) suggested that DES composed of L-lactic acid and nicotinamide and L-lactic acid and L-alanine, both at a molar ratio of 7:1, are promising solvents giving significantly higher yields compared with 60% (v/v) aqueous ethanol and water. However, when β-CD was combined with DES comprised of L-lactic acid and ammonium acetate (molar ratio 7:1), the extraction yields obtained in some instances were equal of even higher. The pattern was not consistent when the yield in total flavonoids (Y TFn ) was considered, indicating water, 60% (v/v) aqueous ethanol and L-lactic acid:sodium acetate (molar ratio 7:1) to be the most efficient solvents. In this case, the effect of β-CD was of rather lower magnitude. The examination of the antioxidant activity of the extracts generated showed that there is a close correlation mainly with their concentration in total polyphenols.

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“…In recent years, green techniques have caught the attention of a considerable number of scientific researchers and have been applied to various health‐related areas. Deep eutectic solvents (DESs) emerged following ionic liquids (ILs) in the area of green chemistry, having been recognised as a new generation of sustainable solvents . Generally, DESs are liquid supermolecules obtained by mixing hydrogen bond acceptors such as quaternary ammonium salts with different hydrogen bond donors .…”

Section: Introductionmentioning

confidence: 99%

“…Deep eutectic solvents (DESs) emerged following ionic liquids (ILs) in the area of green chemistry, having been recognised as a new generation of sustainable solvents. [1][2][3] Generally, DESs are liquid supermolecules obtained by mixing hydrogen bond acceptors such as quaternary ammonium salts with different hydrogen bond donors. 4 Components of DESs are naturally occurring, safe, commonly edible and inexpensive material, such as certain metabolites of cells and organisms including sugars, organic acids, proline and choline chloride.…”

Section: Introductionmentioning

confidence: 99%

Efficient extraction and determination of prenylflavonol glycosides in Epimedium pubescens Maxim. using deep eutectic solvents

Wang

Peng

Zhao

et al. 2019

Phytochemical Analysis

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Introduction The Epimedium herb, Yinyanghuo in Chinese, is a famous Chinese herbal medicine. In this study, an efficient extraction method was developed for the extraction of major bioactive constituent epimedin A, epimedin B, epimedin C and icariin from E. pubescens Maxim. using deep eutectic solvents (DESs). Methodology A series of choline chloride‐based DESs were synthesised for the extraction of four target compounds. DES composed of lactic acid and choline chloride with the ratio of 2:1 was selected as the most promising. Three vital factors affecting the extraction yields including water content, volume of DES aqueous solution and extraction time were optimised systematically by Box–Behnken experimental design in combination with response surface methodology. A high‐performance liquid chromatography ultraviolet (HPLC‐UV) method was developed for the sensitive and accurate quantification. Results The optimal extraction conditions were obtained as follows: water content of 17.5% (v/v), volume of DES aqueous solution 3.14 ml, and extraction time of 21 min. Under the optimal extraction conditions, the developed DES method could supply almost the same extraction yield as 50% ethanol, which were 98%, 99%, 97%, 96% for epimedin A, epimedin B, epimedin C and icariin, respectively. Conclusion The present study exhibited high efficiency in extraction of prenylflavonol glycosides in E. pubescens Maxim. Thus, DESs could be used as an alternative for efficient extraction and quantification of biologically active components from natural medical plants.

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Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media

Cited by 161 publications

References 54 publications

Unraveling the Structural Transformation of Wood Lignin During Deep Eutectic Solvent Treatment

Unraveling the Structural Transformation of Wood Lignin During Deep Eutectic Solvent Treatment

Combination of Lactic Acid-Based Deep Eutectic Solvents (DES) with β-Cyclodextrin: Performance Screening Using Ultrasound-Assisted Extraction of Polyphenols from Selected Native Greek Medicinal Plants

Efficient extraction and determination of prenylflavonol glycosides in Epimedium pubescens Maxim. using deep eutectic solvents

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