Tailoring adhesion of anionic surfaces using cationic PISA-latexes – towards tough nanocellulose materials in the wet state

Abstract

Cationic PISA-latexes exhibit strong adsorption and wet adhesion to anionic surfaces, demonstrated as promising tools for tough materials with high nanocellulose content.

In Situ Encapsulation of Nile Red or Doxorubicin during RAFT‐Mediated Emulsion Polymerization via Polymerization‐Induced Self‐Assembly for Biomedical Applications

“…Given by the theory of PISA using chain‐extension of a hydrophilic polymer with a hydrophobic polymer (insoluble in water above a critical molecular weight resulting in a critical molecular weight resulting in self‐assembly).The molecular weight assessed by SEC was higher than targeted (≈40 000 g mol −1 , DP400 for the PMMA) and the polydispersity ( Ð ) was higher (≈1.5) than expected for a well‐controlled polymerization. However, the results are in agreement with previously published findings for PDMAPMA‐stabilized NPs and partly due to the fact that the SEC is a relative method to assess the molecular weights of polymers 27…”

“…Given the excellent reproducibility offered by RAFT‐mediated PISA and the facile encapsulation of a hydrophobic compound, it is of interest to explore the use of the NPs as nanocarriers for drug‐delivery applications. However, the use of the cationically charged NPs (5.6 meq g −1 )27 may be problematic as cationic NPs have been reported to exert a higher cytotoxic effect than neutral, or negative, particles 29. To assess this, the cell toxicity was investigated by evaluating the cell viability of macrophages (RAW 264.7) and a breast cancer cell line (MCF‐7) after incubating the PDMAPMA‐ b ‐PMMA NPs with cells for 72 h ( Figure ).…”

“…Following previously published protocols, [27] the NPs were synthesized targeting DP 400 of the hydrophobic core and Nile red was left allowed to dissolve in the monomer (MMA) prior to addition. In a typical experiment macroRAFT agent PDMAPMA (100 mg) is dissolved in deionized water for 10 min under magnetic stirring.…”

“…However, the results are in agreement with previously published findings for PDMAPMAstabilized NPs and partly due to the fact that the SEC is a relative method to assess the molecular weights of polymers. [27]…”

“…Phys. 2020, 221, 1900443 charged NPs (5.6 meq g −1 ) [27] may be problematic as cationic NPs have been reported to exert a higher cytotoxic effect than neutral, or negative, particles. [29] To assess this, the cell toxicity was investigated by evaluating the cell viability of macrophages (RAW 264.7) and a breast cancer cell line (MCF-7) after incubating the PDMAPMA-b-PMMA NPs with cells for 72 h (Figure 4).…”