Tailored Supramolecular Cage for Efficient Bio-Labeling

Abstract

Fluorescent chemosensors are powerful imaging tools used in a broad range of biomedical fields. However, the application of fluorescent dyes in bioimaging still remains challenging, with small Stokes shifts, interfering signals, background noise, and self-quenching on current microscope configurations. In this work, we reported a supramolecular cage (CA) by coordination-driven self-assembly of benzothiadiazole derivatives and Eu(OTf)3. The CA exhibited high fluorescence with a quantum yield (QY) of 38.57%, good photoluminescence (PL) stability, and a large Stokes shift (153 nm). Furthermore, the CCK-8 assay against U87 glioblastoma cells verified the low cytotoxicity of CA. We revealed that the designed probes could be used as U87 cells targeting bioimaging.

Recent Developments of Fluorescence Sensors Constructed from Pillar[n]arene-based Supramolecular Architectures Containing Metal Coordination Sites

“…The pillar[n]arenes discussed in this paper include two types: pillar [5]arene and pillar [6]arene [41]. The latter was developed by Yang Y.W.…”

“…Building on this, Dai D.H. and Yang Y.W. constructed a crosslinked supramolecular polymer through host-guest interactions, using a newly designed [2]biphenyl-extended pillar [6]arene with two thymine sites as arms (P4) and a TPE-bridged bis(quaternary ammonium) guest (G2) with AIE properties (Figure 3). The tight T-Hg 2+ -T pairing between the thymine groups and Hg 2+ ions led to the formation of spherical assemblies with an average diameter of 164 nm.…”

“…and Yang Y.W. synthesized a monofunctionalized pillar [6]arene (P19) bearing a single terpyridine arm. They constructed a fluorescent SPN from P19, a TPE aggregation-induced emission generator G8, and 2+ ions as a coordinating linkage.…”

Recent Developments of Fluorescence Sensors Constructed from Pillar[n]arene-Based Supramolecular Architectures Containing Metal Coordination Sites

“…Through noncovalent interactions, supramolecular chemistry unites components with different structures and functionalities [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ], enabling the construction of dynamically reversible smart composites [ 9 , 10 , 11 , 12 ]. Increasing attention has been given to intelligent supramolecular structures formed by host–guest interactions, particularly for their stimuli-responsive properties and expansive application potential.…”

Luminescent covalent organic cages with a C3-symmetric structure for effective enantioseparation

“…These applications include sensing, 1,2 catalysis, [3][4][5] separation, 6,7 gas adsorption, [8][9][10] biological imitation, [11][12][13] and more. [14][15][16][17][18][19][20][21][22] Among the various architectures, threedimensional molecular cages have attracted significant interest for their exceptional structures, properties, and applications. Through coordinative self-assembly, researchers have successfully generated a diverse range of captivating skeletons, such as octahedrons, 23,24 tetrahedrons, [25][26][27][28] spirals, 29,30 capsules, 31,32 and others.…”