Tailored strategies for radiation therapy in classical Hodgkin's lymphoma

A phase II study of dose‐dense and dose‐intense ABVD (ABVDDD‐DI) without consolidation radiotherapy in patients with advanced Hodgkin lymphoma

“…Given the very high rates of early PET‐negativity, a few cycles of ABVD DD‐DI could be optimally and safely implemented by earlier consolidation with brentuximab‐vedotin or other targeted‐agents. Beyond this, availability of an improved ABVD platform allowing omission of consolidation radiotherapy may be advantageous in health‐care settings where the availability of updated radiation delivery modalities is problematic (Terezakis & Kasamon, ). Given that access to novel agents to implement standard ABVD and the highly specialized supportive measures advocated by GHSG investigators to fully exploit survival benefit from escalated BEACOPP may not apply to all health‐care systems worldwide (Skoetz et al , ), ABVD DD‐DI may represent a sound and affordable option for high‐risk patients with HL.…”

“…Despite impressive cure rates obtained with modern chemotherapy, the optimal therapeutic strategy in advanced classic Hodgkin Lymphoma (HL) is still debated due to some remaining open issues (Longo, ). These involve the best choice of upfront chemotherapy (Bauer et al , ; Borchmann et al , ; Uhm & Kuruvilla, ), the duration and intensity of frontline treatment (Carde et al , ; Connors, ; Borchmann et al , ), the value of consolidation radiotherapy (Aleman et al , ; Johnson et al , ; Engert et al , ; Terezakis & Kasamon, ), the role of functional imaging in treatment planning and monitoring (Dann et al , ; Avigdor et al , ; Gallamini & Kostakoglu, ) and the adequacy of risk stratification tools (Moccia et al , ; Scott et al , ).…”

“…radiotherapy (Aleman et al, 2003;Johnson et al, 2010;Engert et al, 2012;Terezakis & Kasamon, 2012), the role of functional imaging in treatment planning and monitoring (Dann et al, 2007;Avigdor et al, 2010;Gallamini & Kostakoglu, 2012) and the adequacy of risk stratification tools (Moccia et al, 2012;Scott et al, 2013).…”