Tailored nanoplatforms with detachable ‘meteorolite’ for photothermal-enhanced programmed tumor therapy

Intervaginal space injection of photothermal chemotherapy nanoparticles for facilitating tumor targeting and improving outcomes in mice

“…PDA-ICG-PTX solutions (500 μg/mL) were irradiated with 808 nm laser (1.4 W/cm 2 ) for 5 min and then added to the dialysis bags (MWCO: 3500Da), the bags were placed in the shakers containing PBS (pH 6.5 or pH 7.4) with a stirring speed of 120 rpm at 37 °C. At the designed time point, 1 mL medium was taken out and the same volume PBS was added, the concentration of PTX released was measured by HPLC [ 21 ].…”

The Graphene Quantum Dots Gated Nanoplatform for Photothermal-Enhanced Synergetic Tumor Therapy

“…Furthermore, the IC 50 values were calculated as shown in Table 2. As a common index, the combination index (CI) value has been widely used to prove the combined effect of two different therapies [14,34]. The CI value of DOX/MCN-SS-GQDs was 0.60 (less than 0.9), indicating the synergistic effect of PTT and chemotherapy.…”

“…Numerous functional PTT materials, including metal oxides or sulfides, MOF-based materials [9], precious metal materials, and carbon-based nanomaterials [10][11][12][13][14], have been created as carriers for NIR absorption agents due to the fast development of PTT. Mesoporous carbon nanoparticles (MCN), one of these PTT adsorbents, have drawn a significant amount of interest owing to their excellent properties, including high surface area and porosity, tailorable mesopore size, and easily modified surface.…”

“…Fortunately, drug delivery systems in response to multifarious stimuli have advanced significantly in recent years. The release of drugs in specific target tissues can be triggered by convenient switching effects brought on by specific stimuli such as intracellular high-concentration glutathione (GSH) [16], lysosomal pH [17], enzymes [18], heat [3], light [14], and magnetic stimuli [19]. Redox potential is one of these stimuli that frequently stimulates intracellularly at the tumor site [20].…”

Doxorubicin-Fe(III)-Gossypol Infinite Coordination Polymer@PDA:CuO2 Composite Nanoparticles for Cost-Effective Programmed Photothermal-Chemodynamic-Coordinated Dual Drug Chemotherapy Trimodal Synergistic Tumor Therapy

“…For multimodal combination tumor therapies, a key challenge is to devise an optimal treatment plan that maximizes the benefits of each therapeutic method and makes the best of each therapeutic modality. − Currently, many multimodal therapies are simply combinations of different treatments without considering the time effect, mechanism of each therapy, and their relationships. Moreover, the state of the tumors (live tumor volume and dispersion) at different stages of treatment is often neglected in most combination therapies, resulting in a simple additive effect of tumor treatment.…”